FlowMoDL is an unrolled neural network designed for highly accelerated 4D flow MRI reconstruction, optimizing both anatomical magnitude and phase-derived velocity accuracy. It alternates a learned (3+1)D spatiotemporal denoiser with conjugate‑gradient data‑consistency updates, using a dual‑pathway conditioning scheme to handle acceleration factors from 10× to 50×. Trained with a deep‑supervision composite loss that penalizes velocity magnitude and angular errors, FlowMoDL outperforms classical and deep‑learning baselines on the multi‑center CMRx4DFlow dataset, achieving superior gradient‑step efficiency and robust convergence across all acceleration factors.
By Tristan Gottwald, Michelle Bruch, Mubashir-Ul Hassan, Fatma Alickovic, Milan Kloiber, Daniel Tenbrinck, Torsten Panholzer, Melanie Schaller, Jana Hutter
arXiv:2608. 13629v1 Announce Type: cross Abstract: Clinically actionable, patient-specific hemodynamic assessment, specifically wall shear stress, vortex structure and pressure distributions, is critical for determining risky or unfavorable evolution in Abdominal Aortic Aneurysms (AAA).
By Oscar L. Cruz-Gonzalez, Val\'erie Deplano, Badih Ghattas
arXiv:2606. 06313v1 Announce Type: cross Abstract: Wall shear stress (WSS) governs near-wall transport dynamics and is a key hemodynamic indicator in cardiovascular flows, yet remains difficult to infer accurately due to the need for precise computation of near-wall velocity gradients.
By Mahmoud Elhadidy, Siva Viknesh, Roshan M. D'Souza, Amirhossein Arzani
arXiv:2608. 03430v1 Announce Type: cross Abstract: Four-dimensional cone beam CT (4D CBCT) is important for image-guided radiation therapy of thoracic cancers, but its use is limited by long scan times, causing high patient dose and motion/sparse-sampling artifacts.
By Ivo Herzig, Pascal Paysan, Daniel Barco, Marc Andr\'e Stadelmann, Frank-Peter Schilling, Igor Peterlik, Michal Walczak, Lijin Aryananda, Woo Sang Ahn, Rudolf Marcel F\"uchslin, Lukas Lichtensteiger
The paper presents a deep learning super‑resolution framework for 4D flow MRI of carotid arteries, using convolutional block attention modules to focus on clinically relevant spatial features and reduce noise. Trained on 120 patients with 240 stenosed carotid arteries, the model leverages patient‑specific CFD simulations as high‑resolution ground truth. Results show a significant reduction in RMSE and improved reconstruction of complex flow patterns compared to a baseline without attention.
By Ali Mokhtari, Dominik Obrist
The paper introduces a physics-informed deep learning framework that reconstructs 3D coronary geometry from dual-view angiography and predicts velocity and pressure fields using a decoupled network with embedded physical priors. Across 32 patients and four flow conditions, the model achieved a trans‑stenotic pressure‑drop error of 2.02% and velocity/pressure relative‑L2 errors of 0.054 and 0.023, respectively, while matching hospital‑measured FFR with 93.8% diagnostic accuracy. The pipeline completes the full angiography‑to‑hemodynamics conversion in about 20 minutes per patient and supports sparse‑data assimilation for revascularization planning.
By Xi Chen, Jianchuan Yang, Hongde Li, Guangxin He, Qiuyu Ye, Qiang Luo, Mao Chen, Wenqi Hu
arXiv:2606. 26764v1 Announce Type: cross Abstract: Developing robust artificial intelligence models for 4D (3D + time) medical imaging is constrained by limited annotated data, inter-device domain shifts, and privacy restrictions.
By Yiheng Cao, Gustavo Andrade-Miranda, Jiatian Zhang, Lingxiao Zhao, Xin Gao
Developing robust artificial intelligence models for 4D (3D + time) medical imaging is constrained by limited annotated data, inter-device domain shifts, and privacy restrictions. To address this, we propose a 4D controllable generative framework for anatomically consistent data augmentation.
The paper introduces a geometry‑guided sampling operator that directs feature sampling rather than altering convolution kernels in 3D encoder‑decoder networks. By predicting local orientations and bounded step sizes, the operator samples symmetrically around each voxel, generating compact geometric and boundary cues that improve fine‑structure segmentation. Replacing stride‑1 and stride‑2 operations in a 3D U‑Net yields consistent gains on BraTS, MSD Hepatic Vessel, and TDSC‑ABUS datasets, with better boundary metrics and fewer parameters, and the operator can be integrated into other backbones without architectural changes.
By Sizhe Wang, Himashi Peiris, Zhaolin Chen
arXiv:2605. 08832v3 Announce Type: replace Abstract: Neural surrogate models for computational fluid dynamics (CFD) are typically trained as forward operators that map explicit problem specifications, such as geometry and boundary conditions, to solution fields.
By Jonas Weidner, Yeray Martin-Ruisanchez, Daniel Rueckert, Benedikt Wiestler, Julian Suk
The study presents a fully automated 4D U‑Net that segments the ascending aorta, arch, and proximal descending aorta in 4D flow MRI using a hybrid 4D convolutional kernel and sparse 4D labels derived from 2D expert contours and centerlines. Trained on 268 scans from eight centers, the model achieved high Dice scores (0.927 internal, 0.911 external) and excellent agreement with expert measurements of peak velocity, net flow, wall shear stress, and diameters (ICC ≥0.954 internal, ≥0.980 external). Compared to frame‑wise 3D networks and semi‑automatic methods, the 4D U‑Net outperformed in diastole and generalised well to independent post‑contrast data.
By Hinrich Rahlfs, Julio Garcia, Chiara Manini, Markus H\"ullebrand, Sebastian Schmitter, Sarah Nordmeyer, Titus K\"uhne, Heiko Stern, Christian Meierhofer, Andreas Harloff, Sebastian Kelle, Alexander Lenz, Peter Bannas, Jeanette Schulz-Menger, Ralf F Trauzeddel, Anja Hennemuth
arXiv:2603. 00205v2 Announce Type: replace-cross Abstract: Generative models, particularly Diffusion Models (DM), have shown strong potential for Computed Tomography (CT) reconstruction serving as expressive priors for solving ill-posed inverse problems.
By Jiayang Shi, Lincen Yang, Zhong Li, Tristan van Leeuwen, Daniel M. Pelt, K. Joost Batenburg