Physics-Informed Hemodynamic Modeling for Data-Free Prediction and Sparse-Data Assimilation

The paper introduces a physics-informed deep learning framework that reconstructs 3D coronary geometry from dual-view angiography and predicts velocity and pressure fields using a decoupled network with embedded physical priors. Across 32 patients and four flow conditions, the model achieved a trans‑stenotic pressure‑drop error of 2.02% and velocity/pressure relative‑L2 errors of 0.054 and 0.023, respectively, while matching hospital‑measured FFR with 93.8% diagnostic accuracy. The pipeline completes the full angiography‑to‑hemodynamics conversion in about 20 minutes per patient and supports sparse‑data assimilation for revascularization planning.

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