The study evaluates whether inflammatory biomarkers can predict cognitive impairment in older Hispanic adults using interpretable machine learning on a small clinical dataset. A leakage‑safe Bernoulli/Categorical Naive Bayes model was trained on 165 participants from the Panama Aging Research Initiative, with continuous predictors discretized via supervised chi‑square and income treated categorically. The biomarker I‑309 (CCL1) emerged as the sole reliable incremental predictor, boosting ROC‑AUC from 0.630 to 0.740 and achieving statistically significant performance across repeated cross‑validation and random partitions.
By Antony Garcia, Gabrielle Britton, Alcibiades Villarreal, Diana Oviedo, Giselle Rangel, Xinming Huang
arXiv:2606. 11267v1 Announce Type: new Abstract: Data leakage -- contamination of a model with information unavailable at baseline -- is the dominant reproducibility failure in machine-learning-based science, yet detection tools require training code, external data, or domain expertise.
By Laurence A. Jacobs
arXiv:2509. 10517v3 Announce Type: replace Abstract: Machine learning can predict in-hospital mortality, but data privacy and the statistical heterogeneity of clinical data hamper its use.
By Rodrigo Tertulino
The paper introduces a framework that distinguishes two causes of saturation in clinical prediction: a learner gap, where the model fails to use available information, and a measurement‑channel ceiling, where the recorded variables limit performance. It provides theoretical characterizations, finite‑sample diagnostics, and empirical audits across three large cohorts, showing that well‑tuned models approach the frontier while deficient learners leave large gaps. A PRISMA‑guided synthesis across 104 tasks reveals consistent channel‑level patterns, suggesting that improving the learner or the measurement channel can audit and potentially lift performance.
By Sayeed Shafayet Chowdhury, Nusrat Jahan, Snehasis Mukhopadhyay, Shiaofen Fang, Vijay R. Ramakrishnan
arXiv:2607. 16253v1 Announce Type: cross Abstract: Machine learning-based Type 2 diabetes risk prediction models obtain good internal validation results but lose effectiveness in real-world applications due to deficient external testing and fairness assessment.
By Rajveer Singh Pall, Sameer Yadav, Siddharth Bhalerao, Sourabh Sahu, Ritu Ahluwalia, Bhaskar Awadhiya
arXiv:2606. 10725v1 Announce Type: new Abstract: Background.
By Olga Shakhmatova, Dmitrii Kriukov, Daniil Larionov, Nikita Khromov, Iaroslav Bespalov, Alexander Zolotarev, Kirill Grishchenkov, Ekaterina Ivanova, Miron Kuznetsov, Ilya Sochenkov, Elizaveta Panchenko, Artem Shelmanov, Dmitry V. Dylov
arXiv:2607. 18828v1 Announce Type: new Abstract: Readiness stress-testing of medical AI has focused on closed-ended and multimodal benchmarks.
By Koyar Afrasyab
arXiv:2607. 15721v1 Announce Type: new Abstract: Cardiometabolic diseases remain among the most persistent drivers of preventable morbidity because diabetes, hypertension, and cardiovascular disease frequently co-occur and share metabolic, vascular, demographic, and behavioral determinants.
By S M Asif Hossain, Ruksat Khan Shayoni, M. F. Mridha, Jungpil Shin
The study evaluates whether mammography foundation models, pretrained for breast cancer tasks, can predict 5‑year major adverse cardiovascular events (MACE) in women using only screening mammograms. In a cohort of 22,497 women (500 MACE events), the models achieved AUROCs of 0.823 and 0.822, outperforming an age‑only baseline. The models also identified higher risk in patients with radiologist‑documented breast arterial calcifications, despite never being trained on that label.
By Paula Feldman, Nusrat Binta Nizam, Sunwoo Kwak, Batuhan Karaman, Katerina Dodelzon, Mert Sabuncu
Deep-learning models can achieve strong chest X-ray (CXR) classification performance without establishing whether their predictions predominantly rely on pulmonary image content. This study evaluates...
The paper introduces a statistically grounded framework for interpretable, rule-based clinical classification using Bernoulli Naïve Bayes (BNB). It employs supervised chi‑square‑guided binarization to convert continuous medical variables into binary indicators, enabling BNB to handle continuous data while maintaining transparency. On three benchmark datasets—Pima Indians Diabetes, Wisconsin Breast Cancer, and Heart Failure Prediction—the method achieved AUCs of 0.800, 0.984, and 0.919, respectively, and demonstrated reliable probability calibration through cross‑validated analysis and post‑hoc beta calibration.
By Antony Garcia, Adrian Noriega, Gabrielle Britton, Xinming Huang
arXiv:2608.27690v1 Announce Type: cross
Abstract: Cardiovascular risk prediction remains limited by incomplete clinical data and imaging biomarkers that reduce computed tomography (CT) to a small num...
By Roy Gabriel, Nattakorn Kittisut, Jamshid Hassanpour, Michael Galarnyk, Abanoub Abdelmalak, Marly van Assen, Carlo N. De Cecco, Arshed Quyyumi, Ali Adibi