The study audited ten different classifiers—including linear, tree‑ensemble, neural, glass‑box, and tabular foundation models—on national health survey data to predict myocardial infarction. By systematically removing features that could cause target leakage, the authors found that all models’ AUROC scores collapsed into a narrow band, indicating that reported high accuracy in prior work was largely due to leakage rather than model sophistication. The glass‑box explainable boosting machine performed comparably to other models while being much faster, and the authors demonstrated that fairness, calibration, and uncertainty can be audited and repaired without sacrificing performance.
By Raad Bin Tareaf, Murad Al-Rajab, Samia Loucif, Samer Ellaham, Cedric Schmitz
The paper introduces a missingness‑aware conformal calibration method for mortality prediction that accounts for cross‑hospital distribution shifts. By selecting a measurement on an independent sample, grouping patients by whether that measurement is recorded, and applying Mondrian calibration within each group, the method avoids reusing calibration outcomes. Experiments on eICU and MIMIC‑IV data show that, compared to pooled calibration, it reduces the worst‑group coverage gap by a median of 1.9 percentage points across six settings, though the benefit varies with predictor and hospital.
By Liang You, Dongwen Ou, Hengyu Shi, Siyuan Dai
arXiv:2606. 11267v1 Announce Type: new Abstract: Data leakage -- contamination of a model with information unavailable at baseline -- is the dominant reproducibility failure in machine-learning-based science, yet detection tools require training code, external data, or domain expertise.
By Laurence A. Jacobs
arXiv:2607. 28608v1 Announce Type: new Abstract: Clinical risk models routinely achieve strong aggregate performance while producing materially different error rates across patient subgroups.
By Sparsh Roy, Samuel Girmachew, Nishita Chavan
arXiv:2509. 19671v3 Announce Type: replace Abstract: Public datasets of Chest X-Rays (CXRs) have long been a popular benchmark for developing machine learning (ML) computer vision models in healthcare.
By Andrew Wang, Jiashuo Zhang, Michael Oberst
The paper introduces alert‑list concordance, a metric that evaluates whether different imputation strategies for ICU sepsis prediction models identify the same high‑risk patients, measured by Jaccard similarity of top‑k% alert sets with bootstrap confidence intervals. Using PhysioNet/CinC 2019 data, the authors compare nine imputation methods and a native‑missingness baseline, finding that many methods have similar AUROC yet produce alert lists that overlap only 51–75% of the time. ForwardFill stands out as an outlier, achieving higher discrimination but lower overlap (40–45%).
By Priyanka Siddappa, Muntaqim Ahmed Raju, Shifat Haider Al Amin, Ruizhe Ma
arXiv:2605. 24212v2 Announce Type: replace-cross Abstract: Deploying clinical prediction models across healthcare systems often fails when key training covariates are unavailable at deployment and labeled outcomes are limited in the target domain.
By Siqi Li, Chuan Hong, Ziye Tian, Benjamin Sieu-Hon Leong, Koshi Nakagawa, Hideharu Tanaka, Sang Do Shin, Khuong Quoc Dai, Do Ngoc Son, Marcus Eng Hock Ong, Nan Liu, Molei Liu
arXiv:2611.07950v1 Announce Type: new
Abstract: Benchmarks of class-imbalance strategies for multimodal chest X-ray (CXR) and electronic health record (EHR) prediction are often evaluated on record-l...
By Dang-Khoa Bui, Quang-Huy Tran, Minh-Khoi Nguyen-Bui, Duc-Tuan Ngo, Thanh-Trong Tran, Tuan-Khoi Nguyen, Hoang-Anh Ngo
The paper introduces a new metric called Localized AUC (LAUC), a weighted version of the traditional AUC, to detect performance heterogeneity in risk prediction models. Using LAUC, the authors develop a method named LOCATOR that identifies patient cohorts where the model’s predictions are inaccurate. They validate LOCATOR on both real-world data and simulations and provide a statistical foundation for applying LAUC in this context.
By Wenye Ren, Anna Gy\H{o}rffy-Kerekes, Tancredi Dorsi, Olga Demler
arXiv:2608. 15725v1 Announce Type: new Abstract: Predictive models in clinical and regulated settings must be accurate and fully auditable.
By Srikumar Krishnamoorthy
arXiv:2509. 10517v3 Announce Type: replace Abstract: Machine learning can predict in-hospital mortality, but data privacy and the statistical heterogeneity of clinical data hamper its use.
By Rodrigo Tertulino
arXiv:2508. 07617v2 Announce Type: replace-cross Abstract: AI has the potential to augment human decision making.
By Sarah Jabbour, David Fouhey, Nikola Banovic, Stephanie D. Shepard, Ella Kazerooni, Michael W. Sjoding, Jenna Wiens