arXiv Machine Learning By Abdul Raheem Shahzad, Muhammad Zaheer Khan, Umar Ajaib, Asad Ur Rehman, Juan Deng, Ming Zhang

Machine Learning for Live-Birth Prediction After IVF/ICSI From Structured Clinical Data: A Systematic Review, Meta-Analysis, and Critical Appraisal

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This systematic review and meta‑analysis examined 48 machine‑learning studies that predict live‑birth outcomes after IVF/ICSI using routine clinical data. The pooled discrimination of internally validated models was an AUC of 0.814, while externally validated models had an AUC of 0.756, with no significant difference between them. Most studies (47/48) were at high or unclear risk of bias, only four assessed calibration, and none demonstrated clinical impact, leading to a low‑to‑very‑low certainty of evidence.

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