Frontier large language models (LLMs) are increasingly integrated into scientific workflows, yet their growing biological capabilities may outpace current safeguards. To assess the biological risks of frontier models, we develop Intern-BioBreaker, a specialized bio-red-teaming model, together with an integrated computational-to-physical framework that couples model-level stress testing with wet-lab validation.
arXiv:2608. 02684v1 Announce Type: cross Abstract: Large Language Models (LLMs) are accelerating biological research, yet this same capability poses a critical biosecurity threat: models that assist in protein engineering can equally be prompted to generate predicted toxin-like sequences, potentially lowering the barrier to biological misuse.
By Shu Quan, Tianfang Hao, Sitong Fang, He Geng, Jiayi Zhou, Boyuan Chen, Kaile Wang, Donghai Hong, Juntao Dai, Yaodong Yang, Jiaming Ji
arXiv:2607. 05462v1 Announce Type: cross Abstract: As AI agents are incorporated into life science workflows, the capabilities that speed discovery might also enable misuse.
By Edwin H. Wintermute, Harmon Bhasin, Christina M. Agapakis, Dianzhuo Wang, Evan Seeyave, Arjun Banerjee, Daniel Fulop, Matthew C. Watson, Adam J. Meyer, Sandrine Boissel, Jens H. Kuhn, Rishi Jain, Noah D. Taylor, Helena Shomar, Patrick M. Boyle, Kenny Workman
arXiv:2607. 05462v2 Announce Type: replace-cross Abstract: As AI agents are incorporated into life science workflows, the capabilities that speed discovery might also enable misuse.
By Edwin H. Wintermute, Harmon Bhasin, Christina M. Agapakis, Dianzhuo Wang, Evan Seeyave, Arjun Banerjee, Daniel Fulop, Matthew C. Watson, Adam J. Meyer, Sandrine Boissel, Jens H. Kuhn, Rishi Jain, Noah D. Taylor, Helena Shomar, Patrick M. Boyle, Kenny Workman
DeepSafe‑SciHazard introduces a real‑world‑grounded benchmark for measuring scientific safety risks, comprising 2,400 hazardous and 600 oversafety questions across 12 disciplines. It defines a decomposed harm scoring system, DeHarm‑Score, that evaluates query severity, refusal behavior, and response‑level risk, further breaking down harm into executability and net‑new risk. An expert‑validation study shows DeHarm‑Score aligns 90.17% better with expert judgments than the best baseline, and the benchmark reveals that deep research agents score 32.3% higher on mean DeHarm‑Score than standard LLMs, highlighting a critical blind spot in current safety defenses.
By Chunxiao Li, Yuan Xiong, Lijun Li, Tianyi Du, Wenlong Zhang, Lei Bai, Jing Shao
arXiv:2607. 18665v1 Announce Type: new Abstract: Large language models (LLMs) increasingly support science, but they can also convert hazardous scientific knowledge into actionable misuse guidance.
By Chunxiao Li, Yuan Xiong, Lijun Li, Tianyi Du, Wenlong Zhang, Lei Bai, Jing Shao
arXiv:2609.16213v1 Announce Type: new
Abstract: Artificial intelligence is reshaping biological research across an increasingly connected digital-to-physical workflow. General-purpose large language...
By Candace S. Y. Chan, Aris Karatzikos, Ilias Georgakopoulos-Soares
Large language models (LLMs) increasingly support science, but they can also convert hazardous scientific knowledge into actionable misuse guidance. Existing benchmarks often rely on templated queries disconnected from real-world hazards, and employ LLM-as-a-Judge paradigms without domain grounding.
arXiv:2606. 11150v1 Announce Type: new Abstract: Large language models (LLMs) are rapidly acquiring capabilities relevant to biological research, from literature synthesis to interpretation of experimental data.
By Andrew Bo Liu, Samira Nedungadi, Bryce Cai, Alex Kleinman, Harmon Bhasin, Seth Donoughe
arXiv:2606. 20502v1 Announce Type: cross Abstract: Whether LLMs scoring well on vulnerability benchmarks genuinely reason about security or merely pattern-match on contaminated data remains unresolved.
By Arastoo Zibaeirad, Marco Vieira
arXiv:2606. 28332v1 Announce Type: cross Abstract: Large language models (LLMs) are increasingly used for medical and health-related questions, yet their safety in high-risk medical scenarios remains poorly understood.
By Yige Li, Jun Sun, Wei Zhao, Zhe Li, Yutao Wu, Hanxun Huang, Xiang Zheng, Xingjun Ma
arXiv:2606. 12429v1 Announce Type: cross Abstract: Muse Spark is the latest large language model developed by Meta.
By Cristina Menghini (Sail), Peter Ney (Sail), Hamza Kwisaba (Sail), Zifan (Sail), Wang, Miles Turpin, Felix Binder, Jean-Christophe Testud, Aidan Boyd, Nathaniel Li, Ivan Evtimov, Klaudia Krawiecka, Arman Zharmagambetov, Jeremy Kritz, Alexander R. Fabbri, Daniel Song, Jinpeng Miao, Joonas Hjelt, Meghna Ramani, Leona Lan, Reza Aghajani, Joanna Bitton, Mahesh Pasupuleti, Devin Norder, Khalid El-Arini, Paridhi Singh, V\'itor Albiero, Sahana CB, Rashnil Chaturvedi, Elahe Dabir, Edoardo Debenedetti, Jim Gust, Ziwen Han, Kat He, Sean Hendryx, Lifeng Jin, Polina Kirichenko, Sandra Lefdal, Kenneth Li, Asad Liaqat, Inna Lin, Despoina Magka, Neal Mangaokar, Ishita Mediratta, Zach Miller, Smitha Milli, Niloofar Mireshghallah, Saba Nazir, Hung Nguyen, Maximilian Nickel, Kelvin Niu, Kerem Oktar, Bhargavi Paranjape, Parth Pathak, Maya Pavlova, Emmanuel Ramirez, David Renardy, Candace Ross, Yasha Sheynin, Claudia Shi, Shivam Singhal, Evangelia Spiliopoulou, Rakshith Sharma Srinivasa, Jamelle Watson-Daniels, Spencer Whitman, Adina Williams, Chen Xing, Andy Zou, Tommy Ma, Siqi Deng, James Beldock, Prashant Ratanchandani, Kate Plawiak, Taesung Lee, Ryan Victory, Lindsay Hundley, Rachad Alao, Himaghna Bhattacharjee, Jianfeng Chi, Gary Frost, Pegah Ghahremani, Niki Howe, Yuheng Huang, Saeed Jahed, Hannah Korevaar, Trang Le, Zhe Liu, Jinghong Luo, Qin Lyu, Nina Mehrabi, Abraham Montilla, Chirag Nagpal, Cyrus Nikolaidis, Rajvardhan Oak, Manoj Ravi, Vidya Sarma, Aman Shankar, Alana Shine, Eric Michael Smith, Mariana Tandon, Michael Tontchev, Caoyu Wang, Zihan Wang, Corinne Wong, Zheng Wu, Hongyuan Zhan, Justin Zhao, Zexuan Zhong, Chengxu Zhuang, Tristan Goodman, Ayaz Minhas, Harrison Rudolph, Victoria Jeffries, Ingrid Dickinson, Alex Vaughan, Lauren Deason, Kamalika Chaudhuri, Julian Michael, Shengjia Zhao, Summer Yue