Large language models (LLMs) increasingly support science, but they can also convert hazardous scientific knowledge into actionable misuse guidance. Existing benchmarks often rely on templated queries disconnected from real-world hazards, and employ LLM-as-a-Judge paradigms without domain grounding.
arXiv:2606. 18936v1 Announce Type: new Abstract: Large language models (LLMs) are increasingly embedded in AI for Science (AI4Science) workflows, from scientific question answering and literature analysis to laboratory planning and autonomous discovery.
By Linghao Feng, Yinqian Sun, Dongqi Liang, Sicheng Shen, Chenfei Yan, Yuxuan Peng, Yilin Zhao, Haibo Tong, Kai Li, FeiFei Zhao, Yi Zeng
Large language models (LLMs) are increasingly embedded in AI for Science (AI4Science) workflows, from scientific question answering and literature analysis to laboratory planning and autonomous discovery. This progress creates an urgent need for safety benchmarks that evaluate not only scientific competence, but also whether models recognize and avoid risks in high-stakes scientific contexts.
arXiv:2606. 28332v1 Announce Type: cross Abstract: Large language models (LLMs) are increasingly used for medical and health-related questions, yet their safety in high-risk medical scenarios remains poorly understood.
By Yige Li, Jun Sun, Wei Zhao, Zhe Li, Yutao Wu, Hanxun Huang, Xiang Zheng, Xingjun Ma
arXiv:2508. 00923v3 Announce Type: replace Abstract: Large language models (LLMs) are increasingly used to answer health-related questions and support healthcare workflows, yet evidence for their safety still relies heavily on static benchmarks that can rapidly become obsolete or be optimized against.
By Jiazhen Pan (Cherise), Bailiang Jian (Cherise), Paul Hager (Cherise), Yundi Zhang (Cherise), Che Liu (Cherise), Friederike Jungmann (Cherise), Hongwei Bran Li (Cherise), Julian Canisius (Cherise), Chenyu You (Cherise), Junde Wu (Cherise), Jiayuan Zhu (Cherise), Fenglin Liu (Cherise), Yuyuan Liu (Cherise), Niklas Bubeck (Cherise), Moritz Knolle (Cherise), Chen (Cherise), Chen (Cherise), Christian Wachinger, Zhenyu Gong, Cheng Ouyang, Georgios Kaissis, Benedikt Wiestler, Daniel Rueckert
arXiv:2601. 17642v2 Announce Type: replace Abstract: Safety alignment in Large Language Models is critical for healthcare; however, reliance on binary refusal boundaries often results in over-refusal of benign queries or unsafe compliance with harmful ones.
By Zhihao Zhang, Liting Huang, Guanghao Wu, Preslav Nakov, Heng Ji, Usman Naseem
arXiv:2606. 08234v1 Announce Type: new Abstract: LLM-based scientific agents have shown strong capacity for autonomous research, yet their safety layers remain structurally divorced from core reasoning: they inspect pipeline outputs rather than shaping the deliberation that produces them.
By Tanush Swaminathan, Runmin Jiang, Letian Zhang, Min Xu
arXiv:2608. 17183v1 Announce Type: new Abstract: Small Language Models (SLMs) are increasingly deployed in resource-constrained, privacy-sensitive settings, where safety and bias failures can cause security and societal risks.
By Nyamtulla Shaik, Fengjun Li, Bo Luo
arXiv:2607. 01153v3 Announce Type: replace-cross Abstract: Safety evaluations for language models increasingly depend on judgments about ambiguous natural-language behaviour: whether a model followed an instruction, refused appropriately, complied with a policy, or misreported progress in an agentic task.
By Brett Reynolds
arXiv:2606. 00160v1 Announce Type: cross Abstract: Large language models (LLMs) suffer from degraded safety capabilities even when fine-tuned with benign datasets.
By Junbo Zhang, Qianli Zhou, Xinyang Deng, Wen Jiang, Jie Pan, Jinbiao Zhu
arXiv:2605. 28591v2 Announce Type: replace-cross Abstract: The validity of AI safety evaluations depends on models behaving consistently across controlled and deployment settings.
By Katharina Deckenbach, Haritz Puerto, Jonas Geiping, Sahar Abdelnabi
arXiv:2606. 00686v1 Announce Type: new Abstract: The prevailing paradigm in large language model (LLM) alignment operates via erasure, filtering unsafe data or training models to strictly refuse harmful prompts.
By Maryam Hashemzadeh, Jerry Huang, Minseon Kim, Marc-Alexandre C\^ot\'e, Sarath Chandar