Large language models (LLMs) are increasingly embedded in AI for Science (AI4Science) workflows, from scientific question answering and literature analysis to laboratory planning and autonomous discovery. This progress creates an urgent need for safety benchmarks that evaluate not only scientific competence, but also whether models recognize and avoid risks in high-stakes scientific contexts.
Frontier large language models (LLMs) are increasingly integrated into scientific workflows, yet their growing biological capabilities may outpace current safeguards. To assess the biological risks of frontier models, we develop Intern-BioBreaker, a specialized bio-red-teaming model, together with an integrated computational-to-physical framework that couples model-level stress testing with wet-lab validation.
arXiv:2606. 18936v1 Announce Type: new Abstract: Large language models (LLMs) are increasingly embedded in AI for Science (AI4Science) workflows, from scientific question answering and literature analysis to laboratory planning and autonomous discovery.
By Linghao Feng, Yinqian Sun, Dongqi Liang, Sicheng Shen, Chenfei Yan, Yuxuan Peng, Yilin Zhao, Haibo Tong, Kai Li, FeiFei Zhao, Yi Zeng
arXiv:2607. 16112v1 Announce Type: new Abstract: Frontier AI companies have published capability thresholds that differ substantially, making it difficult for third parties to verify whether a threshold has been crossed or to compare requirements across companies.
By Wilber Sean Anterola, Matthew Ball, Luis F. Lafuerza, Markov Grey
arXiv:2606. 19899v1 Announce Type: cross Abstract: This paper addresses a rapidly emerging policy challenge: how to generate and interpret credible evidence about the biological capabilities and risks of AI scientists, or agentic AI systems capable of autonomously or collaboratively performing multi-step scientific tasks.
By Patricia Paskov, Jeffrey Lee, Kyle Brady, Alyssa Worland
arXiv:2608. 02684v1 Announce Type: cross Abstract: Large Language Models (LLMs) are accelerating biological research, yet this same capability poses a critical biosecurity threat: models that assist in protein engineering can equally be prompted to generate predicted toxin-like sequences, potentially lowering the barrier to biological misuse.
By Shu Quan, Tianfang Hao, Sitong Fang, He Geng, Jiayi Zhou, Boyuan Chen, Kaile Wang, Donghai Hong, Juntao Dai, Yaodong Yang, Jiaming Ji
arXiv:2607. 22671v1 Announce Type: new Abstract: Foundation-model safety benchmarks capture the AI risks of their time of publication: as models improve and governments pass new AI-safety legislation, their risk taxonomies become incomprehensive and their attack prompts become ineffective.
By Rohan Naphade, Minzhou Pan, Bo Li
arXiv:2608. 07446v1 Announce Type: cross Abstract: Rapid adoption of large language models (LLMs) in enterprise settings has introduced operational, security, and governance risks.
By Afreen Alam, Evgenija Popchanovska, Ana Gjorgjevikj, Maryan Rizinski, Lubomir T. Chitkushev, Irena Vodenska, Dimitar Trajanov
arXiv:2606. 08234v1 Announce Type: new Abstract: LLM-based scientific agents have shown strong capacity for autonomous research, yet their safety layers remain structurally divorced from core reasoning: they inspect pipeline outputs rather than shaping the deliberation that produces them.
By Tanush Swaminathan, Runmin Jiang, Letian Zhang, Min Xu
arXiv:2607. 05462v1 Announce Type: cross Abstract: As AI agents are incorporated into life science workflows, the capabilities that speed discovery might also enable misuse.
By Edwin H. Wintermute, Harmon Bhasin, Christina M. Agapakis, Dianzhuo Wang, Evan Seeyave, Arjun Banerjee, Daniel Fulop, Matthew C. Watson, Adam J. Meyer, Sandrine Boissel, Jens H. Kuhn, Rishi Jain, Noah D. Taylor, Helena Shomar, Patrick M. Boyle, Kenny Workman
Advanced AI can transform biology and medicine—but also raises biosecurity risks. We’re proactively assessing capabilities and implementing safeguards to prevent misuse.
arXiv:2607. 00464v1 Announce Type: new Abstract: Current molecular generation benchmarks emphasize task complexity, molecule novelty, and property alignment; they largely overlook a critical concern: the potential safety risks of AI-generated molecules.
By Tong Xu, Xinzhe Cao, Zhihui Zhu, Keyan Ding, Huajun Chen