arXiv AI

Artificial intelligence and biosecurity: capabilities, threat pathways, and defense-in-depth governance

arXiv AI
Jun 19

Measuring Biological Capabilities and Risks of AI Agents

arXiv:2606. 19899v1 Announce Type: cross Abstract: This paper addresses a rapidly emerging policy challenge: how to generate and interpret credible evidence about the biological capabilities and risks of AI scientists, or agentic AI systems capable of autonomously or collaboratively performing multi-step scientific tasks.

By Patricia Paskov, Jeffrey Lee, Kyle Brady, Alyssa Worland
arXiv AI
Jul 22

BioSecBench-Refusal: A paired metric for performance and alignment in agentic biosecurity risk assessment

arXiv:2607. 05462v2 Announce Type: replace-cross Abstract: As AI agents are incorporated into life science workflows, the capabilities that speed discovery might also enable misuse.

By Edwin H. Wintermute, Harmon Bhasin, Christina M. Agapakis, Dianzhuo Wang, Evan Seeyave, Arjun Banerjee, Daniel Fulop, Matthew C. Watson, Adam J. Meyer, Sandrine Boissel, Jens H. Kuhn, Rishi Jain, Noah D. Taylor, Helena Shomar, Patrick M. Boyle, Kenny Workman
arXiv AI
Jul 8

Evaluating calibrated refusal and safe usefulness in dual-use biology settings

arXiv:2607. 05462v1 Announce Type: cross Abstract: As AI agents are incorporated into life science workflows, the capabilities that speed discovery might also enable misuse.

By Edwin H. Wintermute, Harmon Bhasin, Christina M. Agapakis, Dianzhuo Wang, Evan Seeyave, Arjun Banerjee, Daniel Fulop, Matthew C. Watson, Adam J. Meyer, Sandrine Boissel, Jens H. Kuhn, Rishi Jain, Noah D. Taylor, Helena Shomar, Patrick M. Boyle, Kenny Workman
arXiv AI
Aug 19

Traceable Trust for action-ready artificial intelligence in bioscience

The article introduces Traceable Trust, a framework designed to guide the transition from AI-generated outputs to laboratory actions in bioscience. It outlines a reviewable process that evaluates evidence, claimed capabilities, delegated agency, action thresholds, override mechanisms, and feedback loops. Three case studies demonstrate how the framework can document trust as AI outputs influence scientific work.

By Huayu Xin, Yizhi Cai, Mukilan Deivarajan Suresh, Gavin Michael Farrell, Iwona Gajda, Charlie Harrison, Conor Houghton, Mato Lagator, Yang Lu, Virginia Portillo, Reyer Zwiggelaar, Sebastian Lobentanzer
Hugging Face Trending Papers
Jul 20

An Early Warning of Emerging Biosecurity Risks in Frontier LLMs

Frontier large language models (LLMs) are increasingly integrated into scientific workflows, yet their growing biological capabilities may outpace current safeguards. To assess the biological risks of frontier models, we develop Intern-BioBreaker, a specialized bio-red-teaming model, together with an integrated computational-to-physical framework that couples model-level stress testing with wet-lab validation.

arXiv AI
Jun 12

Muse Spark Safety & Preparedness Report

arXiv:2606. 12429v1 Announce Type: cross Abstract: Muse Spark is the latest large language model developed by Meta.

By Cristina Menghini (Sail), Peter Ney (Sail), Hamza Kwisaba (Sail), Zifan (Sail), Wang, Miles Turpin, Felix Binder, Jean-Christophe Testud, Aidan Boyd, Nathaniel Li, Ivan Evtimov, Klaudia Krawiecka, Arman Zharmagambetov, Jeremy Kritz, Alexander R. Fabbri, Daniel Song, Jinpeng Miao, Joonas Hjelt, Meghna Ramani, Leona Lan, Reza Aghajani, Joanna Bitton, Mahesh Pasupuleti, Devin Norder, Khalid El-Arini, Paridhi Singh, V\'itor Albiero, Sahana CB, Rashnil Chaturvedi, Elahe Dabir, Edoardo Debenedetti, Jim Gust, Ziwen Han, Kat He, Sean Hendryx, Lifeng Jin, Polina Kirichenko, Sandra Lefdal, Kenneth Li, Asad Liaqat, Inna Lin, Despoina Magka, Neal Mangaokar, Ishita Mediratta, Zach Miller, Smitha Milli, Niloofar Mireshghallah, Saba Nazir, Hung Nguyen, Maximilian Nickel, Kelvin Niu, Kerem Oktar, Bhargavi Paranjape, Parth Pathak, Maya Pavlova, Emmanuel Ramirez, David Renardy, Candace Ross, Yasha Sheynin, Claudia Shi, Shivam Singhal, Evangelia Spiliopoulou, Rakshith Sharma Srinivasa, Jamelle Watson-Daniels, Spencer Whitman, Adina Williams, Chen Xing, Andy Zou, Tommy Ma, Siqi Deng, James Beldock, Prashant Ratanchandani, Kate Plawiak, Taesung Lee, Ryan Victory, Lindsay Hundley, Rachad Alao, Himaghna Bhattacharjee, Jianfeng Chi, Gary Frost, Pegah Ghahremani, Niki Howe, Yuheng Huang, Saeed Jahed, Hannah Korevaar, Trang Le, Zhe Liu, Jinghong Luo, Qin Lyu, Nina Mehrabi, Abraham Montilla, Chirag Nagpal, Cyrus Nikolaidis, Rajvardhan Oak, Manoj Ravi, Vidya Sarma, Aman Shankar, Alana Shine, Eric Michael Smith, Mariana Tandon, Michael Tontchev, Caoyu Wang, Zihan Wang, Corinne Wong, Zheng Wu, Hongyuan Zhan, Justin Zhao, Zexuan Zhong, Chengxu Zhuang, Tristan Goodman, Ayaz Minhas, Harrison Rudolph, Victoria Jeffries, Ingrid Dickinson, Alex Vaughan, Lauren Deason, Kamalika Chaudhuri, Julian Michael, Shengjia Zhao, Summer Yue
Hugging Face Trending Papers
Aug 18

Traceable Trust for action-ready artificial intelligence in bioscience

The paper introduces Traceable Trust, a framework designed to guide the transition from AI-generated outputs to laboratory actions in bioscience. It outlines a reviewable process that evaluates evidence, claimed capabilities, delegated agency, action thresholds, override authority, and feedback mechanisms. Three case studies demonstrate how the framework can document trust as AI outputs influence scientific work.

arXiv AI
Sep 3

FUSE: An Evaluating Framework for Dangerous Capabilities of LLMs

The paper introduces FUSE, a modular framework that evaluates large language models (LLMs) for dangerous capabilities across three orthogonal pipelines: Knowledge (K), Defense (D), and Harm (H). Using a chemical‑biological module, the authors assess 12 commercial LLMs, revealing divergent profiles among models and families, and showing that newer models increase knowledge while only partially improving defense. The framework’s reliability is supported by high cross‑judge consistency and low inter‑pipeline correlations.

By Zhengyi Jin, Ru Zhang, Xiao Chen, Xinbo Liu, Jiaxuan Lin, Jia Huang, Jianyi Liu, Zhen Yang
arXiv AI
Sep 1

Science sandboxes measure the scientific capability of AI agents

arXiv:2608.30165v1 Announce Type: cross Abstract: Scientific progress depends not only on finding solutions, but on learning the rules that explain why they work and using that understanding to desig...

By Arya S. Rao, Rodrigo I. Castro, Sager J. Gosai, Kenneth B. Hsu, Yasha Ektefaie, Shantanu Singh, Sangeeta N. Bhatia, Steven K. Reilly, Ryan Tewhey, Eric S. Lander, Pardis C. Sabeti