Frontier large language models (LLMs) are increasingly integrated into scientific workflows, yet their growing biological capabilities may outpace current safeguards. To assess the biological risks of frontier models, we develop Intern-BioBreaker, a specialized bio-red-teaming model, together with an integrated computational-to-physical framework that couples model-level stress testing with wet-lab validation.
arXiv:2608. 14577v1 Announce Type: cross Abstract: Frontier large language models (LLMs) safety evaluation has largely treated harmful generation as an attack outcome rather than as an object of analysis.
By Zhouyuan Ma, Yutao Wu, Hanxun Huang, Xiang Zheng, Xiao Liu, Yixin Cao, Zuxuan Wu, Xingjun Ma, Yu-Gang Jiang
arXiv:2602. 16835v2 Announce Type: replace-cross Abstract: Safety alignment is essential for the responsible deployment of Large Language Models (LLMs).
By Sasha Behrouzi, Lichao Wu, Mohamadreza Rostami, Ahmad-Reza Sadeghi
arXiv:2606. 19168v1 Announce Type: new Abstract: To achieve deeper safety alignment for large language models (LLMs), recent efforts have studied how to push safety interventions earlier into the pretraining stage, primarily by filtering unsafe data or rewriting it into safer forms.
By Jinhan Li, Kexian Tang, Yihan Xu, Zhuorui Ye, Kaifeng Lyu
arXiv:2607. 00572v1 Announce Type: new Abstract: Understanding how aligned LLMs internally represent safety is critical for diagnosing alignment vulnerabilities, as it explains why jailbreaks succeed and informs the design of robust alignment strategies.
By Shei Pern Chua, Fangzhao Wu
arXiv:2607. 19894v1 Announce Type: cross Abstract: Large language models (LLMs) are vulnerable to backdoor attacks, where hidden triggers induce malicious outputs.
By Yuxi Li, Zhibo Zhang, Kailong Wang, Xingshuo Han, Ling Shi, Haoyu Wang
arXiv:2512. 05518v2 Announce Type: replace-cross Abstract: Open-source Large Language Models (LLMs) play a critical role in the democratization of AI, yet their "open" nature introduces more avenues for malicious actors to misuse them for harmful purposes.
By Jason Vega, Gagandeep Singh
arXiv:2608. 14392v1 Announce Type: new Abstract: Neuron- and path-level interventions offer the finest-grained route to defending large language models (LLMs) against jailbreak attacks, yet existing methods fall short of this promise, i.
By Wei Zhao, Zhe Li, Peixin Zhang, Jun Sun
Large language models (LLMs) are vulnerable to backdoor attacks, where hidden triggers induce malicious outputs. Existing defenses generally fall into inference-time detection or training-time mitigation, but face two key limitations.
arXiv:2603. 07445v2 Announce Type: replace-cross Abstract: Large language models (LLMs) often require fine-tuning (FT) to perform well on downstream tasks, but FT can induce safety-alignment drift even when the training dataset contains only benign data.
By Guoli Wang, Haonan Shi, Tu Ouyang, An Wang
arXiv:2608. 06779v1 Announce Type: cross Abstract: Large Language Models (LLMs) have accelerated drug discovery, particularly in the automated design of antimicrobial peptides (AMPs).
By Doniyorkhon Obidov, Xiaolong Guo, Yonghui Li, Kaichen Yang
arXiv:2606. 28332v1 Announce Type: cross Abstract: Large language models (LLMs) are increasingly used for medical and health-related questions, yet their safety in high-risk medical scenarios remains poorly understood.
By Yige Li, Jun Sun, Wei Zhao, Zhe Li, Yutao Wu, Hanxun Huang, Xiang Zheng, Xingjun Ma