Frontier large language models (LLMs) are increasingly integrated into scientific workflows, yet their growing biological capabilities may outpace current safeguards. To assess the biological risks of frontier models, we develop Intern-BioBreaker, a specialized bio-red-teaming model, together with an integrated computational-to-physical framework that couples model-level stress testing with wet-lab validation.
arXiv:2608. 14577v1 Announce Type: cross Abstract: Frontier large language models (LLMs) safety evaluation has largely treated harmful generation as an attack outcome rather than as an object of analysis.
By Zhouyuan Ma, Yutao Wu, Hanxun Huang, Xiang Zheng, Xiao Liu, Yixin Cao, Zuxuan Wu, Xingjun Ma, Yu-Gang Jiang
Safety evaluation is critical for assessing whether aligned Large Language Models (LLMs) remain robust against jailbreak attacks. Existing automated testing methods, however, largely rely on response-...
arXiv:2609.36862v1 Announce Type: cross
Abstract: Fine-tuning-as-a-service lets users adapt a safety-aligned language model to their own data, but it also creates a harmful fine-tuning attack surface...
By Muhammad Zeeshan Akram, Mufid Kamel Marican, Anvesh Reddy Yenugu, Ali Zain Kaimkhani, Minghong Fang
NeuronFuzz is a white‑box fuzzing framework that uses internal safety neurons of large language models as continuous feedback for safety evaluation, eliminating the need to generate full model responses during testing. It constructs a SafetyOracle that converts neuron activations into a differentiable safety alarm score, enabling gradient‑based identification of sensitive template positions and fluent, context‑compatible prompt mutations. Evaluated on 21 text and multimodal models, NeuronFuzz achieves a 76‑100% jailbreak discovery rate on five white‑box source models and demonstrates strong zero‑shot transfer to open‑weight and proprietary targets.
By Zhiyuan Xu, Muhammad Firhard Roslan, Joseph Gardiner, Sana Belguith, Lichao Wu
arXiv:2602. 16835v2 Announce Type: replace-cross Abstract: Safety alignment is essential for the responsible deployment of Large Language Models (LLMs).
By Sasha Behrouzi, Lichao Wu, Mohamadreza Rostami, Ahmad-Reza Sadeghi
arXiv:2606. 19168v1 Announce Type: new Abstract: To achieve deeper safety alignment for large language models (LLMs), recent efforts have studied how to push safety interventions earlier into the pretraining stage, primarily by filtering unsafe data or rewriting it into safer forms.
By Jinhan Li, Kexian Tang, Yihan Xu, Zhuorui Ye, Kaifeng Lyu
Fine-tuning-as-a-service lets users adapt a safety-aligned language model to their own data, but it also creates a harmful fine-tuning attack surface: a small amount of harmful data mixed into an othe...
arXiv:2607. 00572v1 Announce Type: new Abstract: Understanding how aligned LLMs internally represent safety is critical for diagnosing alignment vulnerabilities, as it explains why jailbreaks succeed and informs the design of robust alignment strategies.
By Shei Pern Chua, Fangzhao Wu
arXiv:2607. 19894v1 Announce Type: cross Abstract: Large language models (LLMs) are vulnerable to backdoor attacks, where hidden triggers induce malicious outputs.
By Yuxi Li, Zhibo Zhang, Kailong Wang, Xingshuo Han, Ling Shi, Haoyu Wang
NeuronGuard is a fine‑tuning defense for large language models that hardens them against both jailbreak and neuron‑level attacks. It redistributes safety signals across many neurons by identifying safety‑critical ones with per‑layer linear classifiers, enforcing refusal behavior when those neurons are ablated, and applying KL‑divergence regularization for consistency. A randomized gradient projection preserves task performance, and the authors provide a formal guarantee that NeuronGuard lowers the attack success rate upper bound, with experiments showing near‑zero success rates across multiple models and attack strategies.
By Anjun Gao, Yueyang Quan, Yufei Xia, Zhuqing Liu, Minghong Fang
arXiv:2512. 05518v2 Announce Type: replace-cross Abstract: Open-source Large Language Models (LLMs) play a critical role in the democratization of AI, yet their "open" nature introduces more avenues for malicious actors to misuse them for harmful purposes.
By Jason Vega, Gagandeep Singh