Frontier large language models (LLMs) are increasingly integrated into scientific workflows, yet their growing biological capabilities may outpace current safeguards. To assess the biological risks of frontier models, we develop Intern-BioBreaker, a specialized bio-red-teaming model, together with an integrated computational-to-physical framework that couples model-level stress testing with wet-lab validation.
arXiv:2608. 02684v1 Announce Type: cross Abstract: Large Language Models (LLMs) are accelerating biological research, yet this same capability poses a critical biosecurity threat: models that assist in protein engineering can equally be prompted to generate predicted toxin-like sequences, potentially lowering the barrier to biological misuse.
arXiv:2608. 06779v1 Announce Type: cross Abstract: Large Language Models (LLMs) have accelerated drug discovery, particularly in the automated design of antimicrobial peptides (AMPs).
arXiv:2606. 12429v1 Announce Type: cross Abstract: Muse Spark is the latest large language model developed by Meta.
arXiv:2607. 00464v1 Announce Type: new Abstract: Current molecular generation benchmarks emphasize task complexity, molecule novelty, and property alignment; they largely overlook a critical concern: the potential safety risks of AI-generated molecules.
arXiv:2607. 05462v2 Announce Type: replace-cross Abstract: As AI agents are incorporated into life science workflows, the capabilities that speed discovery might also enable misuse.
arXiv:2606. 11150v1 Announce Type: new Abstract: Large language models (LLMs) are rapidly acquiring capabilities relevant to biological research, from literature synthesis to interpretation of experimental data.
arXiv:2607. 05462v1 Announce Type: cross Abstract: As AI agents are incorporated into life science workflows, the capabilities that speed discovery might also enable misuse.
arXiv:2602. 16835v2 Announce Type: replace-cross Abstract: Safety alignment is essential for the responsible deployment of Large Language Models (LLMs).
arXiv:2606. 28332v1 Announce Type: cross Abstract: Large language models (LLMs) are increasingly used for medical and health-related questions, yet their safety in high-risk medical scenarios remains poorly understood.
arXiv:2512. 14751v3 Announce Type: replace-cross Abstract: Finetuning pretrained large language models (LLMs) has become the standard paradigm for developing downstream applications.
arXiv:2602. 06911v2 Announce Type: replace-cross Abstract: As increasingly capable open-weight large language models (LLMs) are deployed, improving their tamper resistance against unsafe modifications, whether accidental or intentional, becomes critical to minimize risks.
Large language models (LLMs) are increasingly embedded in AI for Science (AI4Science) workflows, from scientific question answering and literature analysis to laboratory planning and autonomous discovery. This progress creates an urgent need for safety benchmarks that evaluate not only scientific competence, but also whether models recognize and avoid risks in high-stakes scientific contexts.