The study evaluates whether inflammatory biomarkers can predict cognitive impairment in older Hispanic adults using interpretable machine learning on a small clinical dataset. A leakage‑safe Bernoulli/Categorical Naive Bayes model was trained on 165 participants from the Panama Aging Research Initiative, with continuous predictors discretized via supervised chi‑square and income treated categorically. The biomarker I‑309 (CCL1) emerged as the sole reliable incremental predictor, boosting ROC‑AUC from 0.630 to 0.740 and achieving statistically significant performance across repeated cross‑validation and random partitions.
By Antony Garcia, Gabrielle Britton, Alcibiades Villarreal, Diana Oviedo, Giselle Rangel, Xinming Huang
arXiv:2606. 11267v1 Announce Type: new Abstract: Data leakage -- contamination of a model with information unavailable at baseline -- is the dominant reproducibility failure in machine-learning-based science, yet detection tools require training code, external data, or domain expertise.
By Laurence A. Jacobs
arXiv:2509. 10517v3 Announce Type: replace Abstract: Machine learning can predict in-hospital mortality, but data privacy and the statistical heterogeneity of clinical data hamper its use.
By Rodrigo Tertulino
The paper introduces a framework that distinguishes two causes of saturation in clinical prediction: a learner gap, where the model fails to use available information, and a measurement‑channel ceiling, where the recorded variables limit performance. It provides theoretical characterizations, finite‑sample diagnostics, and empirical audits across three large cohorts, showing that well‑tuned models approach the frontier while deficient learners leave large gaps. A PRISMA‑guided synthesis across 104 tasks reveals consistent channel‑level patterns, suggesting that improving the learner or the measurement channel can audit and potentially lift performance.
By Sayeed Shafayet Chowdhury, Nusrat Jahan, Snehasis Mukhopadhyay, Shiaofen Fang, Vijay R. Ramakrishnan
arXiv:2607. 16253v1 Announce Type: cross Abstract: Machine learning-based Type 2 diabetes risk prediction models obtain good internal validation results but lose effectiveness in real-world applications due to deficient external testing and fairness assessment.
By Rajveer Singh Pall, Sameer Yadav, Siddharth Bhalerao, Sourabh Sahu, Ritu Ahluwalia, Bhaskar Awadhiya
arXiv:2606. 10725v1 Announce Type: new Abstract: Background.
By Olga Shakhmatova, Dmitrii Kriukov, Daniil Larionov, Nikita Khromov, Iaroslav Bespalov, Alexander Zolotarev, Kirill Grishchenkov, Ekaterina Ivanova, Miron Kuznetsov, Ilya Sochenkov, Elizaveta Panchenko, Artem Shelmanov, Dmitry V. Dylov