arXiv AI

A digital-twin framework for forecasting treatment-day imaging with contour uncertainty in adaptive proton radiotherapy

arXiv AI
1d ago

An Uncertainty-Guided Digital Twin Framework for Online Adaptive Proton Therapy in Head and Neck Cancer: A Feasibility Study

arXiv:2609.39010v1 Announce Type: cross Abstract: Objective: Head and neck (HN) proton therapy spans six to seven weeks of anatomical change, while offline replanning takes about a week. We present a...

By Yizhou Wu, Ryan J. Sanford, Huiqiao Xie, Jie Ding, Shupeng Chen, Tung-Ho Wu, Ping-Hsiu Wu, Justin Roper, Jun Zhou, Minglei Kang, Bill Stokes, Sibo Tian, David S. Yu, Xiaofeng Yang, Chih-Wei Chang
arXiv Computer Vision
Sep 16

Anatomy-Change-Aware Bidirectional Selective State-Space Memory for Clinically Deployed Thoracic Radiotherapy Auto-Contouring

The paper introduces DAMM‑Net++, a 2.5D neural network for thoracic organ‑at‑risk and target volume segmentation that tackles inter‑slice surface incoherence, small low‑contrast target failure, and lack of per‑case reliability signals. Its core is an anatomy‑change‑aware bidirectional selective state‑space memory that propagates context across axial slices, complemented by a boundary‑aware decoder and an uncertainty head for calibrated per‑voxel confidence. Evaluations on 2,146 patients, an external cohort, and a reader study show high Dice scores (0.955), low HD95 (3.78 mm), significant time savings (75‑80 %) for clinicians, and improved junior‑reader performance, with the system fully integrated into a clinical workflow.

By Galib Ahmed, Istiak Ahmed, Aritra Islam Saswato, Asib Mostakim Fony, Kazi Shahriar Sanjid, Md. Tanzim Hossain, Md. Anwarul Islam, Md. Nishan Khan, Md. Misbah Khan, Labiba Faiza Karim, Jobaer Rahman, S M Hasibul Hoque, Rahnuma Shahrin Rista, Kamruzzaman Rumman, Md Arifur Rahman, Syed Md. Akram Hussain, Mohammad Ashrafuzzaman Khan, M. Monir Uddin
arXiv Machine Learning
Sep 14

Observation-Anchored Selective Assimilation for Longitudinal Tumor-State Proxy Forecasting in Post-Treatment Glioma

The paper introduces Observation‑Anchored Selective Assimilation (OASA) for forecasting tumor‑state proxies in post‑treatment glioma patients using serial MRI observations. OASA anchors the patient‑specific state with an intermediate observation and selectively updates it via a tiered rule and voxel‑wise soft gate, outperforming baseline methods in Dice score at certain thresholds. The approach is validated on 120 patient triplets and the code is publicly released.

By Yeonjae Jung, Minwoo Shin
arXiv AI
Sep 1

Extending TotalSegmentator: Predicting Patient and Acquisition Characteristics from CT and MR Images

arXiv:2608.29348v1 Announce Type: new Abstract: Background: Patient details and acquisition metadata are important for clinical decisions, image quality control, and automated research pipelines, but...

By Jakob Wasserthal, Joshy Cyriac, Michael Bach, Kimia Mozahheb Yousefi, Minh-Son To, M\'at\'e Sik, C\'edric H\'emon, Thomas Weikert, Martin Segeroth
arXiv AI
Sep 16

MUMINS: Metadata-conditioned Uncertainty-aware Medical Image Next-state Synthesis

arXiv:2609.17169v1 Announce Type: cross Abstract: Forecasting anatomical changes such as tumor growth and neurodegeneration is a challenging generative vision task. Morphological evolution is subtle...

By Anna Oliveras, Roger Mar\'i, Rafael Redondo, Oriol Guardi\`a, Cynthia Ifeyinwa Ugwu, Ana Tost, Bhalaji Nagarajan, Carolina Migliorelli, Vicent Ribas, Petia Radeva