arXiv AI
An Uncertainty-Guided Digital Twin Framework for Online Adaptive Proton Therapy in Head and Neck Cancer: A Feasibility Study
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arXiv AI
Sep 23
A digital-twin framework for forecasting treatment-day imaging with contour uncertainty in adaptive proton radiotherapy
arXiv:2609.24725v1 Announce Type: cross Abstract: Head-and-neck anatomy changes over a six-to-seven-week proton course, and the anatomy of a later week cannot be imaged when the plan is made. We pres...
arXiv Computer Vision
Sep 16
Anatomy-Change-Aware Bidirectional Selective State-Space Memory for Clinically Deployed Thoracic Radiotherapy Auto-Contouring
The paper introduces DAMM‑Net++, a 2.5D neural network for thoracic organ‑at‑risk and target volume segmentation that tackles inter‑slice surface incoherence, small low‑contrast target failure, and lack of per‑case reliability signals. Its core is an anatomy‑change‑aware bidirectional selective state‑space memory that propagates context across axial slices, complemented by a boundary‑aware decoder and an uncertainty head for calibrated per‑voxel confidence. Evaluations on 2,146 patients, an external cohort, and a reader study show high Dice scores (0.955), low HD95 (3.78 mm), significant time savings (75‑80 %) for clinicians, and improved junior‑reader performance, with the system fully integrated into a clinical workflow.
arXiv AI
Jul 15
BAT-RM: A Boundary-Aware Transformer with Region-Aware Multi-Directional Mamba for Clinically Deployed Cervical Cancer Radiotherapy Auto-Contouring
arXiv:2607. 11949v1 Announce Type: cross Abstract: We present a clinically deployed end-to-end auto-contouring system for cervical cancer radiotherapy planning, anchored by the Boundary-Aware Transformer with Region-Aware Mamba (BAT-RM), a hybrid architecture that integrates Sobel-gated boundary attention, a linear-time, multi-directional Mamba module for long-range context, and a boundary-skeleton-guided fusion gate.
arXiv AI
Jul 24
Equivariant Conditional Diffusion Model for Head and Neck CT Image Synthesis from CBCT
arXiv:2509. 21913v2 Announce Type: replace-cross Abstract: Background: Cone-beam computed tomography CBCT is a commonly used modality for image guided radiotherapy.
arXiv Computer Vision
Aug 28
Parameter-Efficient pretrained-CT-to-MRI Transfer for Rectal Cancer Segmentation: Performance-Calibration Trade-offs
The paper introduces SWIFT, a Swin V2‑based model pretrained on 10,444 3D CT volumes and fine‑tuned for rectal cancer segmentation on T2‑weighted MRI. Four configurations—full fine‑tuning (SWIFT), decoder compression (SWIFTe), low‑rank adaptation (SWIFTe‑LoRA), and a LoRA‑decoder ensemble (SWIFTe‑LDE4)—were evaluated on 247 cases, showing that SWIFTe reduces parameters by 70.1% while improving tumor detection and radiomic agreement. The study also demonstrates a trade‑off between detection and boundary agreement, and highlights that SWIFTe‑LDE4 achieves the lowest calibration errors after temperature scaling.
arXiv AI
Sep 25
CATCH: Counterfactual Anatomical Tissue Inpainting with Conditional Haar Diffusion
CATCH is a conditional 3D diffusion model operating in an invertible Haar-wavelet domain designed to inpaint masked regions in T1‑weighted brain MRI with plausible, tumor‑free tissue while preserving observed anatomy. The model’s denoiser uses noisy target coefficients, voided‑image coefficients, and a signed mask, guided by tumor‑excluded wavelet reconstruction and a hole‑focused loss, and hard compositing ensures observed voxels remain unchanged. Experiments on BraTS data show that a weighted mixture of tumor‑derived, irregular‑blob, and ellipsoidal masks yields the best performance, achieving higher SSIM, PSNR, and lower MSE compared to fixed or random augmentation baselines.