The paper introduces a new framework for identifying average dose-response functions in the presence of unmeasured confounding by using instrumental variables. It defines a uniform regular weighting function and partitions the treatment space into open sets where local identification is possible. For estimation, the authors propose an augmented inverse probability weighted score within a debiased machine learning setting, along with practical guidance for constructing weighting functions, falsification tests for the additive IV condition, and asymptotic theory for kernel regression or empirical risk minimization estimators.
By Shuyuan Chen, Peng Zhang, Yifan Cui
arXiv:2609.22383v1 Announce Type: cross
Abstract: Instrumental variable (IV) methods address treatment endogeneity, but with non-compliance and heterogeneous treatment effects a binary instrument gen...
By Zixuan Yao, Guosheng Yin
The paper introduces new one‑step and targeted minimum loss‑based estimators for the average treatment effect and the average treatment effect on the treated under the front‑door criterion. These estimators use multiple parameterizations of the observed data distribution, can avoid modeling the mediator density, and are compatible with flexible machine‑learning nuisance estimation. The authors derive conditions for root‑n consistency, asymptotic linearity, and develop doubly robust tests for identification assumptions, demonstrating improved efficiency and favorable performance in simulations and real‑world applications in education and emergency medicine.
By Anna Guo, David Benkeser, Razieh Nabi
arXiv:2604. 16763v3 Announce Type: replace Abstract: Causal inference from electronic health records (EHR) is fundamentally limited by unmeasured confounding: critical clinical states such as frailty, goals of care, and mental status are documented in free-text notes but absent from structured data.
By Lei Liu, Jialin Chen, Kathy Macropol
arXiv:2604. 23904v3 Announce Type: replace-cross Abstract: Synthetic tabular data are often evaluated by distributional similarity, privacy distance, or train-on-synthetic-test-on-real predictive performance, but these criteria do not ensure validity for causal inference.
By Yichen Xu
arXiv:2608. 00701v1 Announce Type: cross Abstract: Reweighting source samples to match a target covariate distribution is a standard response to distribution shift when generalizing evidence from one population to another.
By Ying Jin, Ying Jin, Dominik Rothenh\"ausler
arXiv:2505. 17961v4 Announce Type: replace-cross Abstract: Causal inference typically assumes centralized access to individual-level data.
By R\'emi Khellaf, Aur\'elien Bellet, Julie Josse
arXiv:2606. 08305v1 Announce Type: cross Abstract: Externally controlled survival trials are increasingly used when concurrent randomized controls are infeasible, particularly in oncology and rare-disease settings with time-to-event endpoints.
By Se Yoon Lee, Yonghyun Kwon, Jae Kwang Kim
arXiv:2606. 13821v1 Announce Type: new Abstract: Estimating the probability that a treatment outperforms a control for an individual patient, called the Individual Probability of Treatment Benefit (IPTB), offers a clinically intuitive alternative to population-average metrics.
By Lev V. Utkin, Andrei V. Konstantinov, Stanislav K. Kogan, Natalya M. Verbova, Maksim I. Goriunov
arXiv:2609.06294v1 Announce Type: new
Abstract: Estimating conditional average treatment effects (CATE) enables efficient targeting of interventions, but many applications have limited experimental s...
By Maitreyi Swaroop, Shikha Bhat, Samantha Rodriguez, Tamar Krishnamurti, Bryan Wilder
arXiv:2610.18889v1 Announce Type: cross
Abstract: Estimating (heterogeneous) treatment effects is still challenging when the outcome is semicontinuous (i.e., exhibiting both a discrete point mass at...
By Hugo Gobato Souto, Eric Wang, Igor Shuryak
arXiv:2607. 26521v1 Announce Type: new Abstract: Conventional subgroup analyses can yield unstable and difficult-to-interpret conclusions, especially in observational biomedical data where each individual is observed under only one exposure state, true individual treatment effects are unavailable, and causal structure is uncertain.
By Vasundhara Acharya, Bulent Yener