arXiv:2604. 16763v3 Announce Type: replace Abstract: Causal inference from electronic health records (EHR) is fundamentally limited by unmeasured confounding: critical clinical states such as frailty, goals of care, and mental status are documented in free-text notes but absent from structured data.
arXiv:2507. 20993v4 Announce Type: replace-cross Abstract: We study how to learn treatment policies from multimodal electronic health records (EHRs) that consist of tabular data and clinical text.
arXiv:2604. 23904v3 Announce Type: replace-cross Abstract: Synthetic tabular data are often evaluated by distributional similarity, privacy distance, or train-on-synthetic-test-on-real predictive performance, but these criteria do not ensure validity for causal inference.
arXiv:2609.06294v1 Announce Type: new Abstract: Estimating conditional average treatment effects (CATE) enables efficient targeting of interventions, but many applications have limited experimental s...
The paper introduces information set emulation, a method that attaches detailed causal certificates—such as source evidence, timing, and proposed causal roles—to AI‑derived features extracted from electronic health records (EHRs). These certificates provide auditable evidence for causal roles and guide whether a feature can be used for causal inference or should be routed to compatible reporting or separate analyses. The framework integrates with a joint EHR observation map and offers identification, estimation, and diagnostic tools under standard causal assumptions, illustrated through synthetic simulations and a finite‑world example.
arXiv:2603. 19186v3 Announce Type: replace Abstract: Randomized controlled trials (RCTs) are the gold standard for estimating treatment effects, yet they are often underpowered for detecting effect heterogeneity.
arXiv:2607. 27224v1 Announce Type: cross Abstract: External and synthetic control arms (ECAs) are entering psychiatric drug development, but the field lacks a benchmark that evaluates the properties regulators care about: not only how accurately a method reconstructs untreated trajectories, but whether its uncertainty is calibrated, whether it is robust to the informative observation times common in mental-health records (sicker patients are seen more often), and what false-positive rate it induces in go/no-go trial decisions.
arXiv:2608. 19501v1 Announce Type: cross Abstract: Diagnostic medical tests and devices provide useful information for evaluating the potential benefits and risks of therapeutic treatments.
arXiv:2606. 17113v1 Announce Type: new Abstract: Distinguishing causal adverse drug events (ADEs) from spurious correlations remains a central challenge in pharmacovigilance.
arXiv:2606. 05797v1 Announce Type: new Abstract: Longitudinal treatment decisions require predicting potential outcomes under future treatment sequences in the presence of time-varying confounding, heterogeneous patient dynamics, and limited domain-specific data.
The paper introduces Clinical Intent Extraction (CIE), a task that transforms fragmented clinical action annotations into complete structured records called Clinical Intent Representation (CIR). CIR decomposes each action into verb, type, coded target, timing, condition, request‑intent (aligned to HL7 FHIR) and modality, adding dimensions absent in prior datasets. By re‑expressing five heterogeneous corpora into CIR, the authors create CIRCA, a benchmark of 10,011 harmonized intents with human‑validated subsets, crosswalks, and a deterministic FHIR R4 mapper, and demonstrate that existing models perform poorly on the full task, highlighting the need for targeted development.
arXiv:2605.20292v2 Announce Type: replace Abstract: Numerical time-series models effectively process irregular electronic health record (EHR) trajectories, but do not expose which temporal patterns s...
arXiv:2608.29582v1 Announce Type: cross Abstract: Current evaluations of large language models (LLMs) primarily focus on factual knowledge retrieval, overlooking the fundamental challenge of navigati...