One-class artifact detectors for whole-slide images learn normal tissue from a clean training pool and flag departures from it. The pool is built by a preprocessing pipeline whose tissue-detection ste...
arXiv:2609.16032v1 Announce Type: cross
Abstract: Diffusion-based artifact detectors score whole-slide image patches by reconstruction error under a model fine-tuned on clean tissue. We show that con...
By Konstantinos Moutselos, Ilias Maglogiannis
arXiv:2608.30835v1 Announce Type: cross
Abstract: Background and Objective: Quality control is a prerequisite for whole-slide image analysis, yet the benchmarks on which quality-control methods are c...
By Konstantinos Moutselos, Ilias Maglogiannis
CATCH is a conditional 3D diffusion model operating in an invertible Haar-wavelet domain designed to inpaint masked regions in T1‑weighted brain MRI with plausible, tumor‑free tissue while preserving observed anatomy. The model’s denoiser uses noisy target coefficients, voided‑image coefficients, and a signed mask, guided by tumor‑excluded wavelet reconstruction and a hole‑focused loss, and hard compositing ensures observed voxels remain unchanged. Experiments on BraTS data show that a weighted mixture of tumor‑derived, irregular‑blob, and ellipsoidal masks yields the best performance, achieving higher SSIM, PSNR, and lower MSE compared to fixed or random augmentation baselines.
By Simon Winther Albertsen, Hjalte Bjoernstrup, Said Djafar Said, Mostafa Mehdipour Ghazi
arXiv:2608. 03990v1 Announce Type: new Abstract: Synthetic histopathology image generation has emerged as an approach that may address data scarcity in computational pathology, yet current evaluation methodologies may not fully assess synthetic data quality for medical applications.
By Seyed Kahaki, Shijie Li, Weijie Chen, Nicholas Petrick
MIRTO is an evaluation protocol for unsupervised anomaly segmentation in brain MRI that explicitly documents key methodological choices—such as registration alignment, threshold setting, and false‑positive budgeting—and measures their impact. It applies a registration check, uses validation data for thresholding, reports realized false‑positive volumes, and repeats each comparison across 15,552 evaluation pipelines with bootstrap intervals. In a study on four UAD methods and 312 BraTS 2020 subjects, MIRTO revealed that an axis‑order mismatch dramatically lowered a diffusion model’s voxel AUROC, and that many performance differences were driven by lesion definition and threshold transfer rather than model quality.
By Negin Kafee Hernashki, Soumick Chatterjee
arXiv:2602. 02124v2 Announce Type: replace-cross Abstract: Drug-induced toxicity is a leading cause of preclinical and early-clinical failure, making early detection critical.
By Olga Graf, Dhrupal Patel, Peter Gro{\ss}, Charlotte Lempp, Matthias Hein, Fabian Heinemann
arXiv:2607. 05965v1 Announce Type: cross Abstract: Vascular computed tomography datasets are commonly annotated only once per scan, yielding the pervasive yet under addressed problem of single mask annotation noise.
By Yinheng Zhu, Xiaowei Xu
arXiv:2609.37848v1 Announce Type: cross
Abstract: Biomedical machine learning papers often compress model performance into one headline number. That number can look like a property of the model even...
By Bhanu Prakash Vangala, Sowmya Guda, Latha Peddi, Navya Vangala
arXiv:2607. 14984v1 Announce Type: new Abstract: Per-subgroup fairness audits of medical image classifiers face a sample-size problem: minority subgroups in held-out test sets have so few samples that the resulting confidence intervals on per-subgroup performance are wider than the bias the audit is meant to detect.
By Mahmoud Ibrahim, Bart Elen, Chang Sun, Gokhan Ertaylan, Michel Dumontier
The paper introduces "Destroy Me", a hybrid framework that generates realistic histopathology artifacts using Stable Diffusion and physics‑based modeling to create six common artifact types. Artifact realism is evaluated with KID and color Wasserstein metrics, and models trained on these augmented images outperform baselines on lung adenocarcinoma classification, achieving a 10.5% relative boost in macro F1‑score and a 15% increase in Cohen’s Kappa. The study highlights that selective, impact‑weighted augmentation is essential for enhancing robustness while preserving subtle diagnostic features.
By Zuzanna Krawczyk-Borysiak, Adam Krawczyk, Mateusz Miller, Gabriela Kaczmarek, S{\l}awomir Paku{\l}o, Ma{\l}gorzata Sok\'o{\l}, \.Zaneta Swiderska-Chadaj
arXiv:2609.00704v1 Announce Type: new
Abstract: Functional tissue units (FTUs), including tertiary lymphoid structures (TLSs), blood vessels, and glands, encode localized immune, vascular, and epithe...
By Zonghao Liu, Lei Su, Jiguang Yu, Xuqing Geng, Louis Shuo Wang, Jianmin Wang, Jingfeng Liu