MIRTO is an evaluation protocol for unsupervised anomaly segmentation in brain MRI that explicitly documents key methodological choices—such as registration alignment, threshold setting, and false‑positive budgeting—and measures their impact. It applies a registration check, uses validation data for thresholding, reports realized false‑positive volumes, and repeats each comparison across 15,552 evaluation pipelines with bootstrap intervals. In a study on four UAD methods and 312 BraTS 2020 subjects, MIRTO revealed that an axis‑order mismatch dramatically lowered a diffusion model’s voxel AUROC, and that many performance differences were driven by lesion definition and threshold transfer rather than model quality.
arXiv:2608.28714v1 Announce Type: cross Abstract: Objective: Deep learning accelerates brain MRI four- to tenfold, but models can erase lesions or synthesize false tissue - failures pixel-averaged me...
arXiv:2605. 24609v2 Announce Type: replace-cross Abstract: Artificial intelligence is increasingly integrated into radiotherapy workflows, yet such pipelines remain vulnerable to out-of-distribution image data that may introduce unexpected behavior in clinical tasks.
arXiv:2606. 19300v1 Announce Type: cross Abstract: Glioma segmentation in multiparametric MRI is a critical component of treatment planning.
The paper presents a segmentation pipeline for brain metastases in both pre‑ and post‑treatment cases using a 5‑fold nnU‑Net ResEnc‑L ensemble trained on 1,296 four‑modality cases. A rule‑based post‑processing cascade improves the lesion‑wise Dice similarity coefficient (LW‑DSC) for enhancing tumour, tumour core, whole tumour, and resection cavity sub‑regions, achieving LW‑DSC scores of 0.733, 0.751, 0.713, and 0.549 respectively on the official validation leaderboard. The authors conduct a five‑fold out‑of‑fold analysis to validate the robustness of each post‑processing stage, provide a mechanistic explanation of LW‑DSC behaviour, and report thirteen negative results that challenge common intuitions, with all code released under Apache‑2.0.
Medical vision-language models typically generate diagnoses through single-pass inference without indicating which image regions support their conclusions. This lack of spatial grounding limits clinical utility: outputs cannot be audited, and models may hallucinate findings on normal scans.
arXiv:2609.00593v1 Announce Type: new Abstract: Neuroradiologists rarely read a brain MRI in isolation, yet automated brain-MRI report generation has been built almost entirely for single studies. Te...
arXiv:2606. 07381v1 Announce Type: cross Abstract: Background and Purpose: Automated detection of focal cortical dysplasia (FCD) requires large volumes of voxelwise lesion-delineated MRI data, which are difficult to acquire.
arXiv:2507. 21164v2 Announce Type: replace-cross Abstract: Unsupervised anomaly detection (UAD) aims to detect anomalies without labeled data, a necessity in many machine learning applications where anomalous samples are rare or not available.
The paper presents a pragmatic segmentation pipeline for brain metastases in the BraTS 2026 Task 1, using a 5‑fold nnU-Net ResEnc‑L ensemble trained for 1,000 epochs on 1,296 four‑modality cases. A rule‑based post‑processing cascade tuned for the lesion‑wise Dice similarity coefficient (LW‑DSC) improves performance, achieving LW‑DSC scores of 0.733, 0.751, 0.713, and 0.549 on enhancing tumour, tumour core, whole tumour, and resection cavity, respectively. The authors audit each post‑processing stage with a five‑fold out‑of‑fold analysis, confirm two stages as robust, and provide a mechanistic analysis of LW‑DSC, along with thirteen negative results that challenge common intuitions.
arXiv:2608. 16725v1 Announce Type: cross Abstract: Corrupted, inconsistent, or anomalous data silently threatens the safety and reliability of medical AI.
CATCH is a conditional 3D diffusion model operating in an invertible Haar-wavelet domain designed to inpaint masked regions in T1‑weighted brain MRI with plausible, tumor‑free tissue while preserving observed anatomy. The model’s denoiser uses noisy target coefficients, voided‑image coefficients, and a signed mask, guided by tumor‑excluded wavelet reconstruction and a hole‑focused loss, and hard compositing ensures observed voxels remain unchanged. Experiments on BraTS data show that a weighted mixture of tumor‑derived, irregular‑blob, and ellipsoidal masks yields the best performance, achieving higher SSIM, PSNR, and lower MSE compared to fixed or random augmentation baselines.
arXiv:2608.28681v1 Announce Type: new Abstract: Probability calibration aligns model confidence with predictive accuracy, enabling clinicians to identify unreliable segmentation regions. This alignme...