arXiv:2608. 03990v1 Announce Type: new Abstract: Synthetic histopathology image generation has emerged as an approach that may address data scarcity in computational pathology, yet current evaluation methodologies may not fully assess synthetic data quality for medical applications.
arXiv:2601. 08127v2 Announce Type: replace-cross Abstract: Expert-annotated training data remains the critical bottleneck for AI in histopathology, particularly for rare pathologies where even dozens of cases may be unavailable.
arXiv:2601.17228v2 Announce Type: replace Abstract: Deep learning models in computational pathology often fail to generalize across cohorts and institutions due to domain shift. Existing approaches e...
The paper introduces Interpretable Utility Similarity (IUS), a novel metric for quantifying how closely a synthetic image set matches a real image set in terms of usefulness for deep‑learning clinical decision support systems. IUS is interpretable, leveraging generalized neural additive models to explain why one synthetic dataset may outperform another based on clinically relevant image features. Experiments on color medical imaging modalities—endoscopic, dermoscopic, and fundus—show that selecting synthetic images with high IUS can boost classification performance by up to 54.6%, and the method also generalizes to grayscale X‑ray and ultrasound data.
The paper introduces "Destroy Me", a hybrid framework that generates realistic histopathology artifacts using Stable Diffusion and physics‑based modeling to create six common artifact types. Artifact realism is evaluated with KID and color Wasserstein metrics, and models trained on these augmented images outperform baselines on lung adenocarcinoma classification, achieving a 10.5% relative boost in macro F1‑score and a 15% increase in Cohen’s Kappa. The study highlights that selective, impact‑weighted augmentation is essential for enhancing robustness while preserving subtle diagnostic features.
The paper presents a systematic evaluation of six unsupervised image‑to‑image generative models for virtual Sirius Red staining of mouse liver tissue from routine H&E slides. It benchmarks these models across 54 scaling configurations on a newly released paired H&E‑to‑SR dataset, assessing perceptual, distributional, and task‑specific performance, and further trains the best models into deep ensembles to quantify epistemic uncertainty. The study finds that GAN‑based and diffusion‑based methods differ markedly across these metrics, indicating that reliable virtual staining requires reporting and selecting on all three axes simultaneously.
The paper introduces an unsupervised approach to medical image segmentation by training a Denoising Diffusion Probabilistic Model (DDPM) on 21 unlabeled abdominal CT scans to learn anatomical features. The encoder weights from the DDPM are transferred to a U‑Net for downstream segmentation on the BTCV multi‑organ dataset, resulting in a significant Dice score improvement for liver segmentation from 0.75 to 0.93. In low‑data regimes, diffusion‑pretrained models retain robust performance, achieving high Dice scores even with only 10% of labeled data.
arXiv:2606. 18354v1 Announce Type: cross Abstract: Recent advances in generative machine learning models have significantly improved medical imaging, offering promising solutions for data augmentation, privacy preservation, and improved model generalization.
arXiv:2609.32876v2 Announce Type: replace-cross Abstract: State-of-the-art pathology foundation models, trained on millions of histology tiles, can fail to preserve tissue similarity when comparisons...
arXiv:2607. 18882v1 Announce Type: cross Abstract: Validating Explainable Artificial Intelligence (XAI) methods in medical imaging requires ground-truth data with known locations of informative features.
arXiv:2606. 06983v1 Announce Type: cross Abstract: Computational pathology requires visual representations that transfer across diverse clinical endpoints and remain robust to variation in magnification, staining, scanner type, slide preparation, and input resolution.
arXiv:2607. 04401v1 Announce Type: cross Abstract: How robust and generalisable are pathology foundation models and have their scaling limites been reached?
Acquiring pixel-level annotations for medical image segmentation is a severe bottleneck. Traditional U-Net architectures, while effective, learn local texture patterns and lack awareness of global ana...