DiaSeg extracts diagonal segments from Dynamic Time Warping (DTW) paths, characterizing each with five geometric features to preserve local alignment information. In a study of 91 subjects across six clinical conditions, these segments revealed consistent unsupervised patterns aligned with biomechanical phases and achieved near-perfect separation of healthy and pathological gait. While cycle‑based methods reached higher overall accuracy, DiaSeg offers phase‑specific interpretability, pinpointing where coordination breaks down within the gait cycle.
arXiv:2606. 06196v1 Announce Type: new Abstract: Huntington's disease (HD) is a progressive brain disorder that gradually affects movement, cognitive function, and behavior.
arXiv:2606. 07135v1 Announce Type: new Abstract: Huntington's disease (HD) is a progressive neurodegenerative disorder that affects motor, cognitive, and behavioral functions, where accurate characterization of disease progression remains essential to improve patient outcome and quality of life.
The paper presents a diagnostic framework for Alzheimer’s disease that uses the Large Brain Model (LaBraM), a foundation model pretrained on over 2,500 hours of EEG data, to generate high‑dimensional latent embeddings. These embeddings are fed into a non‑linear Random Forest classifier, achieving an ROC‑AUC of 89.36% ± 3.49%, PR AUC of 81.45% ± 4.43%, and Balanced Accuracy of 82.44% ± 4.34% in a subject‑independent 5‑fold cross‑validation setting, using only 8‑second EEG segments. Post‑hoc occlusion and neurophysiological alignment analyses confirm that the model captures clinically validated biomarkers such as occipital‑frontal Alpha and Theta rhythm degradation and correlates with cognitive performance and clinical severity.
arXiv:2607. 14190v1 Announce Type: new Abstract: Amyotrophic lateral sclerosis (ALS) is a progressive and heterogeneous neurodegenerative disease in which predicting clinically meaningful milestones, such as assistive device use, remains challenging.
arXiv:2608. 06122v1 Announce Type: cross Abstract: Inspired by recent evidence that transformer architectures benefit from Self-PreTraining (SPT) on long-context benchmarks, we investigate whether similar gains extend to multimodal, multivariate, and even simple univariate medical time series.
arXiv:2605. 15862v2 Announce Type: replace Abstract: Understanding adaptive biomechanical systems requires distinguishing observable performance, static multivariate representation, longitudinal displacement, and internal approximation of observed change.
arXiv:2607. 22508v1 Announce Type: new Abstract: Electroencephalography (EEG) is widely used to diagnose neurological conditions, but its analysis usually relies on either predefined spectral features or deep neural networks.
arXiv:2609.22956v1 Announce Type: new Abstract: Parkinson's disease alters gait and bilateral coordination, but machine-learning performance also depends on how continuous gait signals are represente...
arXiv:2607. 01838v1 Announce Type: new Abstract: Counterfactual explanations (CEs) for multivariate time-series classifiers are often difficult to interpret in domains where experts reason in terms of semantic feature groups rather than individual channels.
arXiv:2601. 20503v2 Announce Type: replace-cross Abstract: White matter hyperintensities (WMH) and ischaemic stroke lesions (ISL) are key imaging biomarkers of cerebral small vessel disease (SVD) detectable on magnetic resonance imaging (MRI).
arXiv:2608. 08173v1 Announce Type: cross Abstract: Longitudinal MRI enables sensitive measurement of structural brain change for studying aging and neurodegenerative disease.
Counterfactual explanations (CEs) for multivariate time-series classifiers are often difficult to interpret in domains where experts reason in terms of semantic feature groups rather than individual channels. In rehabilitation movement analysis with multi-sensor inertial measurement units (IMUs), clinicians interpret motion through muscle-group and joint-segment abstractions; yet, most existing counterfactual methods operate at the channel level, producing scattered and biomechanically incoherent explanations.