The paper presents a diagnostic framework for Alzheimer’s disease that uses the Large Brain Model (LaBraM), a foundation model pretrained on over 2,500 hours of EEG data, to generate high‑dimensional latent embeddings. These embeddings are fed into a non‑linear Random Forest classifier, achieving an ROC‑AUC of 89.36% ± 3.49%, PR AUC of 81.45% ± 4.43%, and Balanced Accuracy of 82.44% ± 4.34% in a subject‑independent 5‑fold cross‑validation setting, using only 8‑second EEG segments. Post‑hoc occlusion and neurophysiological alignment analyses confirm that the model captures clinically validated biomarkers such as occipital‑frontal Alpha and Theta rhythm degradation and correlates with cognitive performance and clinical severity.
arXiv:2609.22092v1 Announce Type: cross Abstract: Electroencephalography (EEG) is a low-cost and non-invasive signal source for dementia screening, yet existing EEG-based studies remain difficult to...
arXiv:2607. 24519v1 Announce Type: cross Abstract: Pretrained EEG foundation models are increasingly proposed for clinical decoding, but their transfer across populations and robustness to negative controls remain unclear.
Pretrained EEG foundation models are increasingly proposed for clinical decoding, but their transfer across populations and robustness to negative controls remain unclear. We benchmark six models (LaBraM, EEGMamba, CBraMod, REVE, BENDR, and BIOT) on five clinical tasks across four datasets using frozen linear probes with leave-one-subject-out, subject-grouped, or explicitly identified recording-level splits.
arXiv:2607. 24519v2 Announce Type: replace Abstract: Pretrained EEG foundation models are proposed for clinical decoding, but whether reported gains transfer across populations or survive negative controls is unclear.
arXiv:2608.24597v1 Announce Type: cross Abstract: Electroencephalography (EEG) is a widely used window into human brain function, but most EEG models remain tied to a one-dataset-one-model supervised...
arXiv:2607. 22508v1 Announce Type: new Abstract: Electroencephalography (EEG) is widely used to diagnose neurological conditions, but its analysis usually relies on either predefined spectral features or deep neural networks.
arXiv:2607. 28687v1 Announce Type: cross Abstract: As populations age, cognitive decline from mild cognitive impairment (MCI) to dementia is a defining health challenge of the coming decades, yet routine assessment often misses its earliest signs.
Brain4FMs is a unified benchmark for evaluating brain foundation models (BFMs) on both scalp EEG and intracranial EEG (iEEG). It incorporates 17 representative models and 21 public datasets spanning clinical diagnosis, sleep staging, communication, and affective computing, and offers dataset-aware preprocessing, cross‑subject evaluation, and standardized downstream workflows. The benchmark highlights that no single BFM consistently outperforms others across all tasks, modalities, and adaptation protocols, prompting further exploratory analyses of model‑specific spatial, spectral, and discrete representations.
arXiv:2607. 26746v1 Announce Type: cross Abstract: Accurate identification of Alzheimers disease (AD) using resting-state functional magnetic resonance imaging (rs-fMRI) remains challenging due to the high dimensionality, noise, and complex inter-regional dependencies inherent in functional brain connectivity, which limit the effectiveness of traditional approaches based on handcrafted connectivity features or conventional machine learning models.
NeuroAtlas is the largest EEG benchmark to date, comprising 42 datasets and 260,000 hours of clinical EEG data across epilepsy, sleep medicine, brain age estimation, and brain‑computer interfaces. The study evaluates foundation models (FMs) for EEG against supervised baselines and generic time‑series FMs, finding that EEG‑specific FMs do not consistently outperform generic ones. It also demonstrates that standard machine‑learning metrics are inadequate for clinical relevance, advocating for task‑specific measures such as event‑level decision quality, hypnogram features, and brain‑age gap.
The paper introduces SYMBA, a self‑supervised pretraining framework tailored for structural T1‑weighted brain MRI. SYMBA uses anatomically constrained masking, a multi‑scale structural similarity reconstruction loss, and a progressive curriculum to capture distributed morphometric patterns. Evaluated on nine heterogeneous cohorts and two unseen datasets, SYMBA outperforms existing neuroimaging foundation models, achieving high AUROC scores for Alzheimer’s disease classification, mild cognitive impairment conversion, and amyloid status prediction, and shows strong sample efficiency in low‑label settings.
arXiv:2608. 13676v1 Announce Type: new Abstract: Objective: Foundation models represent the next advancement in AI for EEG analysis; however current explainable AI techniques provide attribution scores in the time-channel input space, which is mismatched to clinical intuition about EEG.