The paper presents a diagnostic framework for Alzheimer’s disease that uses the Large Brain Model (LaBraM), a foundation model pretrained on over 2,500 hours of EEG data, to generate high‑dimensional latent embeddings. These embeddings are fed into a non‑linear Random Forest classifier, achieving an ROC‑AUC of 89.36% ± 3.49%, PR AUC of 81.45% ± 4.43%, and Balanced Accuracy of 82.44% ± 4.34% in a subject‑independent 5‑fold cross‑validation setting, using only 8‑second EEG segments. Post‑hoc occlusion and neurophysiological alignment analyses confirm that the model captures clinically validated biomarkers such as occipital‑frontal Alpha and Theta rhythm degradation and correlates with cognitive performance and clinical severity.
arXiv:2607. 24519v1 Announce Type: cross Abstract: Pretrained EEG foundation models are increasingly proposed for clinical decoding, but their transfer across populations and robustness to negative controls remain unclear.
Pretrained EEG foundation models are increasingly proposed for clinical decoding, but their transfer across populations and robustness to negative controls remain unclear. We benchmark six models (LaBraM, EEGMamba, CBraMod, REVE, BENDR, and BIOT) on five clinical tasks across four datasets using frozen linear probes with leave-one-subject-out, subject-grouped, or explicitly identified recording-level splits.
arXiv:2607. 24519v2 Announce Type: replace Abstract: Pretrained EEG foundation models are proposed for clinical decoding, but whether reported gains transfer across populations or survive negative controls is unclear.
arXiv:2608.24597v1 Announce Type: cross Abstract: Electroencephalography (EEG) is a widely used window into human brain function, but most EEG models remain tied to a one-dataset-one-model supervised...
arXiv:2607. 22508v1 Announce Type: new Abstract: Electroencephalography (EEG) is widely used to diagnose neurological conditions, but its analysis usually relies on either predefined spectral features or deep neural networks.
arXiv:2607. 28687v1 Announce Type: cross Abstract: As populations age, cognitive decline from mild cognitive impairment (MCI) to dementia is a defining health challenge of the coming decades, yet routine assessment often misses its earliest signs.
Brain4FMs is a unified benchmark for evaluating brain foundation models (BFMs) on both scalp EEG and intracranial EEG (iEEG). It incorporates 17 representative models and 21 public datasets spanning clinical diagnosis, sleep staging, communication, and affective computing, and offers dataset-aware preprocessing, cross‑subject evaluation, and standardized downstream workflows. The benchmark highlights that no single BFM consistently outperforms others across all tasks, modalities, and adaptation protocols, prompting further exploratory analyses of model‑specific spatial, spectral, and discrete representations.
arXiv:2607. 26746v1 Announce Type: cross Abstract: Accurate identification of Alzheimers disease (AD) using resting-state functional magnetic resonance imaging (rs-fMRI) remains challenging due to the high dimensionality, noise, and complex inter-regional dependencies inherent in functional brain connectivity, which limit the effectiveness of traditional approaches based on handcrafted connectivity features or conventional machine learning models.
arXiv:2608. 13676v1 Announce Type: new Abstract: Objective: Foundation models represent the next advancement in AI for EEG analysis; however current explainable AI techniques provide attribution scores in the time-channel input space, which is mismatched to clinical intuition about EEG.
EEG-Xplain introduces a unified attribution framework to interpret EEG foundation models such as BIOT, LaBraM, and EEGMamba. The framework combines gradient, perturbation, and activation-based methods to analyze model behavior across spatial, temporal, and frequency dimensions, identifying critical channels, decision-relevant signal segments, and contributions of canonical EEG rhythms. It evaluates explanation reliability with population-level metrics and uses large language models to convert structured attributions into natural-language reports, demonstrating consistency with known neurophysiological markers on benchmark datasets.
arXiv:2607. 11656v1 Announce Type: cross Abstract: Accurate diagnostic classification and disease-severity prediction for Alzheimer's disease are hampered by the incompleteness and heterogeneity of real-world clinical data.
arXiv:2607. 24519v3 Announce Type: replace-cross Abstract: EEG foundation-model gains may depend on cohort, montage, or probe design.