arXiv:2606. 06196v1 Announce Type: new Abstract: Huntington's disease (HD) is a progressive brain disorder that gradually affects movement, cognitive function, and behavior.
arXiv:2606. 07135v1 Announce Type: new Abstract: Huntington's disease (HD) is a progressive neurodegenerative disorder that affects motor, cognitive, and behavioral functions, where accurate characterization of disease progression remains essential to improve patient outcome and quality of life.
arXiv:2608. 06430v1 Announce Type: new Abstract: Learning from Electronic Health Records (EHRs) has gained significant attention due to its potential to improve clinical prediction.
DiaSeg extracts diagonal segments from Dynamic Time Warping (DTW) paths, characterizing each with five geometric features to preserve local alignment information. In a study of 91 subjects across six clinical conditions, these segments revealed consistent unsupervised patterns aligned with biomechanical phases and achieved near-perfect separation of healthy and pathological gait. While cycle‑based methods reached higher overall accuracy, DiaSeg offers phase‑specific interpretability, pinpointing where coordination breaks down within the gait cycle.
The paper introduces Explainable Graph-theoretical Machine Learning (XGML) to build individual metabolic brain graphs from FDG-PET data and identify subgraphs predictive of multivariate Alzheimer’s disease outcomes. Using ADNI data, the best model—kernel density estimation with Hellinger distance and random forest—achieved a Pearson correlation of 0.595 across eight cognitive scores, with the highest performance on ADAS13, ADAS11, and ADASQ4. Key edges were found to be jointly but differentially predictive, indicating potential network biomarkers for cognitive decline, though external validation on OASIS3 showed weaker performance likely due to cohort differences.
arXiv:2607. 25609v1 Announce Type: cross Abstract: Understanding disease trajectories from longitudinal clinical data remains challenging due to complex temporal dynamics and heterogeneous patient cohorts.
arXiv:2606. 03322v1 Announce Type: cross Abstract: The graphical representation of the brain offers critical insights into diagnosing and prognosing neurodegenerative disease via relationships between regions of interest (ROIs).
arXiv:2606. 03310v1 Announce Type: cross Abstract: Understanding complex interactions between brain regions is critical for early neurodegenerative disease classification such as Alzheimer's Disease (AD) and Parkinson's Disease (PD).
arXiv:2607. 14190v1 Announce Type: new Abstract: Amyotrophic lateral sclerosis (ALS) is a progressive and heterogeneous neurodegenerative disease in which predicting clinically meaningful milestones, such as assistive device use, remains challenging.
arXiv:2111. 05385v3 Announce Type: replace Abstract: Obesity is a major health problem, increasing the risk of various major chronic diseases, such as diabetes, cancer, and stroke.
Functional brain networks exhibit a hierarchical organization across ROI, community, and whole-brain levels, supporting local processing, inter-community coordination, and global integration. Recent studies have demonstrated that brain community-aware modeling is beneficial for both diagnosis and biomarker identification of brain networks.
arXiv:2608.20380v1 Announce Type: cross Abstract: Resting-state functional magnetic resonance imaging (rs-fMRI) has enabled non-invasive mapping of functional brain interactions for computer-aided di...
arXiv:2607. 04912v1 Announce Type: cross Abstract: In patients with breast cancer, pathological complete response (pCR) has been established as a clinically meaningful surrogate marker for long-term outcomes.