Brain4FMs is a unified benchmark for evaluating brain foundation models (BFMs) on both scalp EEG and intracranial EEG (iEEG). It incorporates 17 representative models and 21 public datasets spanning clinical diagnosis, sleep staging, communication, and affective computing, and offers dataset-aware preprocessing, cross‑subject evaluation, and standardized downstream workflows. The benchmark highlights that no single BFM consistently outperforms others across all tasks, modalities, and adaptation protocols, prompting further exploratory analyses of model‑specific spatial, spectral, and discrete representations.
By Fanqi Shen, Enhong Yang, Jiahe Li, Junru Hong, Xiaoran Pan, Zhizhang Yuan, Meng Li, Yang Yang
arXiv:2606. 19888v1 Announce Type: cross Abstract: Modeling long-sequence medical time series data, such as electrocardiograms (ECG), poses significant challenges due to high sampling rates, multichannel signal complexity, inherent noise, and limited labeled data.
By Feng Wu, Harsh Deep, Eric Lehman, Sanyam Kapoor, Guoshuai Zhao, Rahul Krishnan, Gari Clifford, Li-wei H Lehman
arXiv:2506.20354v3 Announce Type: replace-cross
Abstract: Learning from multi-variate time-series with heterogeneous channel configurations remains a fundamental challenge for deep neural networks, p...
By Francesco Carzaniga, Michael Hersche, Abu Sebastian, Kaspar Schindler, Abbas Rahimi
The paper presents a diagnostic framework for Alzheimer’s disease that uses the Large Brain Model (LaBraM), a foundation model pretrained on over 2,500 hours of EEG data, to generate high‑dimensional latent embeddings. These embeddings are fed into a non‑linear Random Forest classifier, achieving an ROC‑AUC of 89.36% ± 3.49%, PR AUC of 81.45% ± 4.43%, and Balanced Accuracy of 82.44% ± 4.34% in a subject‑independent 5‑fold cross‑validation setting, using only 8‑second EEG segments. Post‑hoc occlusion and neurophysiological alignment analyses confirm that the model captures clinically validated biomarkers such as occipital‑frontal Alpha and Theta rhythm degradation and correlates with cognitive performance and clinical severity.
By Maggie Lin, Chung-Lin Hou, Tzyy-Ping Jung
arXiv:2507. 12645v1 Announce Type: cross Abstract: The increasing need for accurate and unified analysis of diverse biological signals, such as ECG and EEG, is paramount for comprehensive patient assessment, especially in synchronous monitoring.
By Mohammed Guhdar, Ramadhan J. Mstafa, Abdulhakeem O. Mohammed
arXiv:2607. 25244v1 Announce Type: new Abstract: Foundation models for 12-lead electrocardiograms (ECGs) transfer well across clinical tasks, but the physiological knowledge encoded in their representations remains opaque.
By Yixuan Duan, Arjun Naik, Sadeer Al-Kindi, Wei Qiu
arXiv:2607. 21384v1 Announce Type: new Abstract: Electroencephalography (EEG) models used for epilepsy are often limited to specific datasets and tasks.
By Targol Bakhtiarvand, Jugal Kalita, Adham Atyabi
NeuroECG is a deep learning framework that repurposes a pretrained ECG foundation model to predict neurological outcomes after cardiac arrest without using electroencephalography (EEG). The model fine‑tunes the backbone with a gradual unfreezing strategy on single‑channel bedside ECG, aggregates multiple ECG segments via quantile pooling and PCA, and achieves an AUROC of 0.7333 using ECG alone. When combined with static clinical covariates, NeuroECG improves performance to an AUROC of 0.8077 and an AUPRC of 0.8970, demonstrating that bedside ECG can serve as a low‑cost, auxiliary prognostic tool in an EEG‑free setting.
By Jiaju Gao, Yi Zhao, Chenyang Xu, Yuxi Zhou, Hao Wang
LEAD is a gated temporal‑spatial Transformer foundation model designed for EEG‑based Alzheimer's disease detection. It was trained on the world’s largest EEG‑AD corpus of 2,238 subjects and uses a subject‑regularized strategy and medical contrastive learning across 13 datasets. LEAD outperforms existing methods on five downstream AD datasets, achieving the best average ranking across 20 evaluations.
By Yihe Wang, Nan Huang, Nadia Mammone, Marco Cecchi, Xiang Zhang
Electroencephalography (EEG) provides a non-invasive window into dynamic brain activity, yet modeling long-horizon EEG sequences remains challenging due to their high temporal complexity, substantial...
NeuroAtlas is the largest EEG benchmark to date, comprising 42 datasets and 260,000 hours of clinical EEG data across epilepsy, sleep medicine, brain age estimation, and brain‑computer interfaces. The study evaluates foundation models (FMs) for EEG against supervised baselines and generic time‑series FMs, finding that EEG‑specific FMs do not consistently outperform generic ones. It also demonstrates that standard machine‑learning metrics are inadequate for clinical relevance, advocating for task‑specific measures such as event‑level decision quality, hypnogram features, and brain‑age gap.
By Konstantinos Kontras, Trui Osselaer, Stylianos G. Mouslech, Angeliki-Ilektra Karaiskou, Guido Gagliardi, Thomas Strypsteen, Mohammad Hossein Badiei, Anku Rani, Maarten Vanmarcke, Miguel Bhagubai, Chanakya Ekbote, Jaedong Hwang, Christos Chatzichristos, Paul Pu Liang, Maarten De Vos
arXiv:2509. 17920v2 Announce Type: replace Abstract: Current deep learning models for electroencephalography (EEG) are often task-specific and depend on large labeled datasets, limiting their adaptability.
By Jamiyan Sukhbaatar, Satoshi Imamura, Ibuki Inoue, Shoya Murakami, Kazi Mahmudul Hassan, Seungwoo Han, Ingon Chanpornpakdi, Toshihisa Tanaka