The paper introduces CytoCRF, a conditional random field framework tailored for cytology images. It adapts pairwise terms to focus on chromatin and cytology-specific staining and enriches neighborhood information by combining multiple backbone models. Across ten cytology datasets, CytoCRF surpasses existing CRF methods at all annotation budgets, achieving up to +13.6 percentage points over the best baseline and +33.7 over zero‑shot performance with only 50 annotations.
By Manon Dausort, Tiffanie Godelaine, Karim El Khoury, Maxime Zanella, Christophe De Vleeschouwer, Beno\^it Macq
arXiv:2602.06674v2 Announce Type: replace-cross
Abstract: High-quality annotated datasets are crucial for advancing machine learning in medical image analysis. However, a critical gap exists: most da...
By Yonghao Si, Xingyuan Zeng, Zhao Chen, Libin Zheng, Caleb Chen Cao, Lei Chen, Jian Yin
arXiv:2608. 14414v1 Announce Type: new Abstract: Cytometry measures the complex characteristics of single cells (e.
By Syed Abdul Haseeb Qadri, Bjarne C. Hiller, Felix Blanke, Vanja Sophie Cangalovic, Kutalm{\i}\c{s} Co\c{s}kun, Amin Mirzaei, Tom Siegl, Sebastian Bader, Thomas Kirste, Martin Becker
arXiv:2511. 05150v2 Announce Type: replace-cross Abstract: Molecular biomarker testing in pathology is often costly and tissue-consuming, limiting scalable clinical deployment.
By Jingsong Liu, Han Li, Zhengyang Xu, Franz-Leonard Klaus, Fabian St\"ogbauer, Shihui Zu, Weiwei Zhou, Atsuko Kasajima, Felix Schicktanz, Alexander Muckenhuber, Julius Shakhtour, Jiale Yu, Tiannan Zheng, Xun Ma, Maggie Wang, Christian Grashei, Bao Li, Guiyang Jiang, Hongming Xu, Shaohua Kevin Zhou, Nassir Navab, Peter J. Sch\"uffler
arXiv:2608. 10657v1 Announce Type: cross Abstract: Leukemia cell image classification is challenged by real-world domain shifts from acquisition, staining, illumination, and site protocols, causing single-dataset models to generalize poorly in real clinical scenarios.
By Carlos Zamora, Hiram Zuniga, Ulises Orozco-Rosas, Kenia Picos
TAM-Chain is a multi‑scale thyroid cytology classification framework that uses Absorbing Markov Chains and Shannon Entropy to quantify uncertainty and dynamically decide when to stop processing and refer to a specialist. It processes images at 10×, 20×, and 40× magnifications, achieving a Macro F1 score of 0.9741 on an internal test set with a 0 % false‑negative rate, and maintains a Macro F1 of 0.7026 on an external validation set with severe domain shift. The method outperforms single‑magnification baselines by adaptively adjusting stopping steps and triggering specialist referrals, thereby reducing critical diagnostic errors.
By Hai Pham Ngoc
CellPath-Bench is a new benchmark that evaluates whole-slide cellular representations in pathology foundation models (PFMs) by using 25 spatially aligned H&E–Xenium tissue sections from 11 organs and over 7 million cells. It introduces metrics such as Cell Representation Advantage (CRA) and Cell Representation Transferability (CRT) to assess how well frozen PFMs encode cell-type information and generalize across tissue sections, datasets, and organs. The benchmark was applied to 30 PFMs, revealing significant model-dependent differences in cell-type decodability and cross-domain generalization, and offers a standardized framework for auditing cellular information in frozen PFM representations.
By Bokai Zhao, Yiyang Zhang, Hanqing Chao, Yawei Ma, Long Bai, Tai Ma, Minfeng Xu, Ming Song, Tianzi Jiang
arXiv:2608. 02615v1 Announce Type: cross Abstract: Cancer diagnosis and characterization require integrating complementary evidence from radiology, pathology, genomics, and clinical metadata.
By Ahnaf Munir, Dannong Wang, Michael W. McDonald, Mubarak Shah, Pegah Khosravi, Yu Tian
arXiv:2606. 06224v1 Announce Type: cross Abstract: Explanations of multiple instance learning (MIL) models are widely used for validation and discovery in digital histopathology.
By Yanqing Luo (Berlin Institute for the Foundations of Learning and Data, Berlin, Germany, Machine Learning Group, Technische Universit\"at Berlin, Berlin, Germany), Julius Hense (Berlin Institute for the Foundations of Learning and Data, Berlin, Germany, Machine Learning Group, Technische Universit\"at Berlin, Berlin, Germany), Niklas Preni{\ss}l (Institute of Pathology, Charit\'e Universit\"atsmedizin, Berlin, Germany, Berlin Institute of Health at Charit\'e -- Universit\"atsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charit\'e Digital Clinician Scientist Program, Berlin, Germany), Andreas Mock (Institute of Pathology, Ludwig Maximilian University of Munich, Munich, Germany, Division of Translational Medical Oncology, DKFZ, Heidelberg, Germany, NCT Heidelberg, Heidelberg, Germany, German Cancer Consortium), Klaus-Robert M\"uller (Berlin Institute for the Foundations of Learning and Data, Berlin, Germany, Machine Learning Group, Technische Universit\"at Berlin, Berlin, Germany, Department of Artificial Intelligence, Korea University, Seoul, Korea, Max-Planck Institute for Informatics, Saarbr\"ucken, Germany), Thomas Schnake (Department of Chemistry, Chemical Physics Theory Group, University of Toronto, Canada, Vector Institute for Artificial Intelligence, Toronto, Canada, Acceleration Consortium, University of Toronto, Canada), Mina Jamshidi Idaji (Berlin Institute for the Foundations of Learning and Data, Berlin, Germany, Machine Learning Group, Technische Universit\"at Berlin, Berlin, Germany)
arXiv:2607. 14116v1 Announce Type: cross Abstract: Free-form radiology reports contain rich clinical descriptions, yet converting them for reliable segmentation remains challenging due to the inherent variability of natural language.
By Anghong Du, Theodoros N. Arvanitis, Colin Watts, Alejandro F. Frangi, Le Zhang
arXiv:2606. 12346v1 Announce Type: cross Abstract: Hematoxylin and eosin (H&E) staining is the cornerstone of histopathology, yet scalable, quantitative analysis of H&E whole-slide images (WSIs) remains a central challenge in computational pathology.
By Kai Standvoss, Miriam H\"agele, Rosemarie Krupar, Julika Ribbat-Idel, Jennifer Altsch\"uler, Gerrit Erdmann, Hans Pinckaers, Evelyn Ramberger, Madleen Drinkwitz, \'Ad\'am N\'arai, Alexander M\"ollers, Katja Lingelbach, Sebastian Kons, Lukas H\"onig, Recepcan Adig\"uzel, Joana Bai\~ao, Alberto Megina Gonzalo, Marius Teodorescu, Marie-Lisa Eich, Paolo Chetta, Shakil Merchant, Verena Aumiller, Simon Schallenberg, Andrew Norgan, Klaus-Robert M\"uller, Lukas Ruff, Maximilian Alber, Frederick Klauschen
arXiv:2609.12835v1 Announce Type: new
Abstract: Bone-marrow cytology is inherently structured: each cell belongs to a hematopoietic lineage, and many cell types lie on ordered maturation trajectories...
By Afshin Bozorgpour, Peter Sch\"uffler, Edgar Jost, Dorit Merhof