AdaptiveCDM is a modular framework for source‑free few‑shot domain adaptation in cell detection, enabling a pretrained model to adapt to new imaging domains using only a handful of labeled target images and no source data. It combines Resolution‑Aware Augmentation (RAug) to balance scarce, class‑imbalanced samples while preserving cellular morphology, and Category‑Aware Representation Learning (CARL) to strengthen class‑consistent proposals for better localization and classification. Experiments on M5 and Raabin‑WBC datasets show that AdaptiveCDM achieves competitive or superior mAP scores compared to state‑of‑the‑art methods under their respective supervision settings.
By Nimra Dilawar, Sara Nadeem, Javed Iqbal, Waqas Sultani, Mohsen Ali
arXiv:2606. 29949v1 Announce Type: cross Abstract: H&E-stained whole-slide images offer cohort-scale availability and rich spatial context but lack molecular specificity, whereas bulk RNA-seq provides transcriptome-wide resolution at high cost with limited archival availability.
By Dominik Winter, Dominik Vonficht, Lo\"ic Le Bescond, Christian Gebbe, Marco Rosati, Richard J. Chen, Markus Schick, Ross Stewart, Nicolas Brieu
HERO (Histology Encoder for Robust Representation in Oncology) is a ViT‑G/14 pathology foundation model trained with DINO and iBOT objectives and refined using high‑resolution Gram anchoring on a 500‑million‑tile corpus from about 575,000 clinical whole‑slide images. It demonstrates superior robustness to center, scanner, and stain variation compared to other state‑of‑the‑art foundation models, while maintaining competitive performance on tile‑level classification, segmentation, and gene‑expression prediction. Across 39 slide‑level clinical tasks, HERO ranks first on average and achieves the best average rank across six benchmark frameworks under an equal‑weighted analysis.
By Zhi Li (Caris Life Sciences, Irving, TX, United States), Eghbal Amidi (Caris Life Sciences, Irving, TX, United States), Yating Cheng (Caris Life Sciences, Irving, TX, United States), Tyson Dawson (Caris Life Sciences, Irving, TX, United States), Gorkem Can Ates (Caris Life Sciences, Irving, TX, United States), Shuzhen Kuang (Caris Life Sciences, Irving, TX, United States), Norsang Lama (Caris Life Sciences, Irving, TX, United States), Md Ashequr Rahman (Caris Life Sciences, Irving, TX, United States), Zhiying Lu (Caris Life Sciences, Irving, TX, United States), Elisabeth K. Kong (Caris Life Sciences, Irving, TX, United States), Milan Radovich (Caris Life Sciences, Irving, TX, United States), David Spetzler (Caris Life Sciences, Irving, TX, United States), Matthew Oberley (Caris Life Sciences, Irving, TX, United States), George W. Sledge (Caris Life Sciences, Irving, TX, United States), Ming Chen (Caris Life Sciences, Irving, TX, United States)
arXiv:2609.36429v1 Announce Type: new
Abstract: Predicting gene expression from H&E-stained histology images offers a scalable alternative to costly spatial transcriptomics, yet most existing methods...
By Zijun Gao, Chunbin Gu, Jinxi Xiang, Xiangde Luo, Pheng-Ann Heng
arXiv:2606. 06983v1 Announce Type: cross Abstract: Computational pathology requires visual representations that transfer across diverse clinical endpoints and remain robust to variation in magnification, staining, scanner type, slide preparation, and input resolution.
By Bokai Zhao, Yiyang Zhang, Long Bai, Tai Ma, Hanqing Chao, Minfeng Xu
arXiv:2609.24736v1 Announce Type: cross
Abstract: Mitotic figure (MF) analysis supports tumor grading and prognostic assessment, but automated models remain sensitive to differences in tissue type an...
By Trinh T. L. Vuong, Simon Graham, Quoc Dang Vu, Phat T. H. Ho, Jeewoo Lim, Mostafa Jahanifar, Nasir Rajpoot, Jin T. Kwak
An interpretable multi‑instance learning classifier based on a decision tree was developed to predict NPM1 and FLT3‑ITD mutations in acute myeloid leukemia using routine flow cytometry data. In cross‑validation on 197 patients, the model achieved AUROCs of 0.96 for NPM1 and 0.86 for FLT3‑ITD, outperforming a clinical baseline and matching deep learning methods. On an independent cohort of 161 patients, it maintained high performance with AUROCs of 0.90 and 0.82, and positive predictive values of 0.87 and 0.68, while cell‑level interpretation recovered known immunophenotypic signatures.
By Jonathan Legrand (IMB, MONC), Aguirre Mimoun (CHU Bordeaux), Baudouin Denis de Senneville (IMB, MONC), Audrey Bidet (CHU Bordeaux), Pierre-Yves Dumas (CHU Bordeaux, Inserm U1312 - BRIC), Christ\`ele Etchegaray (MONC, IMB)
arXiv:2608.28923v1 Announce Type: cross
Abstract: Data augmentation is a cornerstone of deep learning pipelines, yet existing strategies treat it as a static, model-agnostic preprocessing step, eithe...
By Noah Videcrantz, Mostafa Mehdipour Ghazi
arXiv:2505.03380v2 Announce Type: replace
Abstract: Accurate delineation of tumors and surrounding organs-at-risk is essential for radiotherapy, surgery and treatment response assessment, yet remains...
By Haonan Wang, Jiaji Mao, Lehan Wang, Qixiang Zhang, Marawan Elbatel, Yi Qin, Huijun Hu, Baoxun Li, Wenhui Deng, Weifeng Qin, Hongrui Li, Jialin Liang, Jun Shen, Xiaomeng Li
arXiv:2607. 00385v1 Announce Type: cross Abstract: Automated malaria diagnosis from blood smear microscopy is a critical challenge in global health AI; in resource-limited settings, the scarcity of expert microscopists remains the primary bottleneck to timely and accurate diagnosis.
By Kaysarul Anas Apurba, Md Hasibul Hasan, Mohammed Ali, Tanzilur Rahman
The paper introduces CytoCRF, a conditional random field framework tailored for cytology images. It adapts pairwise terms to focus on chromatin and cytology-specific staining and enriches neighborhood information by combining multiple backbone models. Across ten cytology datasets, CytoCRF surpasses existing CRF methods at all annotation budgets, achieving up to +13.6 percentage points over the best baseline and +33.7 over zero‑shot performance with only 50 annotations.
By Manon Dausort, Tiffanie Godelaine, Karim El Khoury, Maxime Zanella, Christophe De Vleeschouwer, Beno\^it Macq
The paper introduces a semantic‑guided multimodal preprocessing technique that fuses nuclei classification maps with RGB histopathology images for Vision Transformer‑based grading of clear cell renal cell carcinoma. By concatenating classification map channels and applying multiplicative modulation, the method achieves a balanced accuracy of 0.916, markedly surpassing an RGB‑only baseline (0.707) and prior max‑voting approaches (0.427). Sensitivity analysis shows the 21‑percentage‑point improvement remains robust under simulated perturbations matching current nuclei classifier error rates, indicating effective use of imperfect nuclear‑level information.
By Fatemeh Javadian, Zhu Chen, Zahra Aminparast, Johannes Stegmaier