arXiv:2606. 12346v1 Announce Type: cross Abstract: Hematoxylin and eosin (H&E) staining is the cornerstone of histopathology, yet scalable, quantitative analysis of H&E whole-slide images (WSIs) remains a central challenge in computational pathology.
arXiv:2607. 03253v1 Announce Type: cross Abstract: As hematoxylin & eosin (H&E) staining constitutes the primary entry point in routine diagnostic workflows, computer-aided diagnosis from whole-slide H&E images is of particular clinical relevance.
arXiv:2511. 05150v2 Announce Type: replace-cross Abstract: Molecular biomarker testing in pathology is often costly and tissue-consuming, limiting scalable clinical deployment.
arXiv:2606. 29949v1 Announce Type: cross Abstract: H&E-stained whole-slide images offer cohort-scale availability and rich spatial context but lack molecular specificity, whereas bulk RNA-seq provides transcriptome-wide resolution at high cost with limited archival availability.
HERO (Histology Encoder for Robust Representation in Oncology) is a ViT‑G/14 pathology foundation model trained with DINO and iBOT objectives and refined using high‑resolution Gram anchoring on a 500‑million‑tile corpus from about 575,000 clinical whole‑slide images. It demonstrates superior robustness to center, scanner, and stain variation compared to other state‑of‑the‑art foundation models, while maintaining competitive performance on tile‑level classification, segmentation, and gene‑expression prediction. Across 39 slide‑level clinical tasks, HERO ranks first on average and achieves the best average rank across six benchmark frameworks under an equal‑weighted analysis.
arXiv:2606. 17702v1 Announce Type: cross Abstract: Characterising the tumour microenvironment (TME) from routine H&E-stained histology images requires simultaneous cell segmentation, feature extraction, and interpretable clinical reporting.
arXiv:2606. 07368v1 Announce Type: cross Abstract: Automated mitosis detection is a well-established task in computational pathology.
arXiv:2607. 20896v1 Announce Type: new Abstract: Spatial transcriptomics assays remain costly and technically demanding, restricting transcriptome-wide profiling to specialist settings and preventing routine clinical deployment.
arXiv:2607. 18218v1 Announce Type: cross Abstract: Foundation models have emerged as a driving force in computational pathology, with the potential to transform cancer diagnosis, prognosis, and treatment selection by learning transferable representations from large-scale histopathology data.
arXiv:2606. 03644v1 Announce Type: new Abstract: Comprehensive molecular profiling is essential for modern precision oncology but remains hindered by prohibitive costs, specimen exhaustion, and protracted turnaround times.
The paper introduces CoPath, a lightweight framework for diagnosing peripheral neuroblastic tumors (pNTs) from whole-slide images. CoPath combines CoHisNet, a multi‑scale feature‑fusion network that replaces traditional MLPs with Kolmogorov‑Arnold Network layers for efficient nonlinear modeling, and PathVote, which aggregates patch‑level predictions using pathology‑informed priors. Experiments on a private pNT cohort and the public BreakHis dataset show that CoPath matches or surpasses existing classifiers while reducing computational complexity.
CellPath-Bench is a new benchmark that evaluates whole-slide cellular representations in pathology foundation models (PFMs) by using 25 spatially aligned H&E–Xenium tissue sections from 11 organs and over 7 million cells. It introduces metrics such as Cell Representation Advantage (CRA) and Cell Representation Transferability (CRT) to assess how well frozen PFMs encode cell-type information and generalize across tissue sections, datasets, and organs. The benchmark was applied to 30 PFMs, revealing significant model-dependent differences in cell-type decodability and cross-domain generalization, and offers a standardized framework for auditing cellular information in frozen PFM representations.
Recent advances in pathology foundation models have enabled accurate prediction of spatial transcriptomics (ST) from routine H&E images. However, existing explainability methods for vision transformer...