arXiv:2609.00396v1 Announce Type: new Abstract: Histopathological whole slide images (WSIs) are central to cancer diagnosis, but their gigapixel scale, tissue heterogeneity, weak slide-level supervis...
The study investigates whether pathology foundation models (PFMs) carry center-related biases into whole-slide image (WSI) classification. By training models with increasing class-center correlations and evaluating six PFMs across four datasets and two MIL aggregators, the authors introduce the Area Under the Cramér's V Curve (AUCC) to measure both accuracy and degradation due to spurious correlations. Results reveal that center information propagates to WSI predictions, with robustness varying by PFM and MIL strategy, and that ComBat harmonization does not consistently improve robustness.
LanGuSTE is a patch‑selection framework for whole slide image analysis that uses vision‑language models and large language model knowledge. It introduces Cross‑Scale Visual Prompt Tuning to align low‑resolution and high‑resolution patches, and a coarse‑to‑fine selection module that encodes only informative high‑resolution patches. Experiments show LanGuSTE cuts overall processing time to about one‑third of the baseline while matching or surpassing diagnostic performance of exhaustive and state‑of‑the‑art methods.
arXiv:2606. 06864v1 Announce Type: cross Abstract: Multiple instance learning (MIL) has become a standard paradigm for whole slide image (WSI) analysis in digital pathology, as it enables slide-level prediction without dense annotations.
HERO (Histology Encoder for Robust Representation in Oncology) is a ViT‑G/14 pathology foundation model trained with DINO and iBOT objectives and refined using high‑resolution Gram anchoring on a 500‑million‑tile corpus from about 575,000 clinical whole‑slide images. It demonstrates superior robustness to center, scanner, and stain variation compared to other state‑of‑the‑art foundation models, while maintaining competitive performance on tile‑level classification, segmentation, and gene‑expression prediction. Across 39 slide‑level clinical tasks, HERO ranks first on average and achieves the best average rank across six benchmark frameworks under an equal‑weighted analysis.
arXiv:2609.24894v1 Announce Type: cross Abstract: Whole-slide pathology images (WSIs) contain gigapixel-scale visual content, creating a major scalability challenge for slide-level multimodal large l...
The paper introduces SlideTIM, a transductive few‑shot classification method tailored for whole‑slide images (WSIs). SlideTIM extends the LC‑TIM approach by adding a spatial‑latent regularizer and a class‑distribution prior, ensuring that spatially and semantically similar patches receive consistent predictions and that predicted class proportions are calibrated. Experiments on four histology datasets show that SlideTIM outperforms existing TIM variants, boosting macro‑F1 scores by up to 8.1 percentage points over the best baseline and 19.4 percentage points over zero‑shot predictions at one shot.
AtlasPatch is a scalable, high‑throughput whole‑slide image preprocessing method that uses a foundation‑model‑based tissue detector operating at thumbnail resolution. By updating only 0.076% of the SAM2 model weights and leveraging a curated dataset of 30,000 thumbnail‑mask pairs, it generates accurate tissue masks and directly produces patch coordinates at the desired magnification, eliminating repeated patch‑level inference. The approach achieves 0.986 precision, is up to 16× faster than existing deep‑learning methods, and maintains downstream multiple‑instance learning performance across six slide‑level classification tasks.
arXiv:2609.24116v1 Announce Type: new Abstract: Although deep learning has advanced Whole Slide Image (WSI) Analysis, tissue artifacts like bubbles and folds often cause silent failures by concealing...
arXiv:2608.22066v1 Announce Type: cross Abstract: Attention-based multiple instance learning (ABMIL) using pathology foundation model embeddings is effective for slide-level tasks, but exhaustive inf...
arXiv:2608.08374v3 Announce Type: replace Abstract: Transformer models are increasingly used for whole-slide image analysis in computational pathology. Yet, WSIs differ fundamentally from natural ima...
arXiv:2607. 14703v1 Announce Type: cross Abstract: Multiple instance learning (MIL) has become the main paradigm for whole-slide image (WSI) analysis in computational pathology.