arXiv:2601. 08127v2 Announce Type: replace-cross Abstract: Expert-annotated training data remains the critical bottleneck for AI in histopathology, particularly for rare pathologies where even dozens of cases may be unavailable.
arXiv:2608. 03990v1 Announce Type: new Abstract: Synthetic histopathology image generation has emerged as an approach that may address data scarcity in computational pathology, yet current evaluation methodologies may not fully assess synthetic data quality for medical applications.
arXiv:2601.17228v2 Announce Type: replace Abstract: Deep learning models in computational pathology often fail to generalize across cohorts and institutions due to domain shift. Existing approaches e...
The paper introduces "Destroy Me", a hybrid framework that generates realistic histopathology artifacts using Stable Diffusion and physics‑based modeling to create six common artifact types. Artifact realism is evaluated with KID and color Wasserstein metrics, and models trained on these augmented images outperform baselines on lung adenocarcinoma classification, achieving a 10.5% relative boost in macro F1‑score and a 15% increase in Cohen’s Kappa. The study highlights that selective, impact‑weighted augmentation is essential for enhancing robustness while preserving subtle diagnostic features.
arXiv:2609.24116v1 Announce Type: new Abstract: Although deep learning has advanced Whole Slide Image (WSI) Analysis, tissue artifacts like bubbles and folds often cause silent failures by concealing...
HERO (Histology Encoder for Robust Representation in Oncology) is a ViT‑G/14 pathology foundation model trained with DINO and iBOT objectives and refined using high‑resolution Gram anchoring on a 500‑million‑tile corpus from about 575,000 clinical whole‑slide images. It demonstrates superior robustness to center, scanner, and stain variation compared to other state‑of‑the‑art foundation models, while maintaining competitive performance on tile‑level classification, segmentation, and gene‑expression prediction. Across 39 slide‑level clinical tasks, HERO ranks first on average and achieves the best average rank across six benchmark frameworks under an equal‑weighted analysis.
arXiv:2609.21698v1 Announce Type: new Abstract: Deep learning segmentation of renal tumors requires large annotated datasets, yet clinical deployments typically offer only a handful of tumor-positive...
arXiv:2607. 12464v1 Announce Type: cross Abstract: When labeled data are scarce, off-the-shelf diffusion models can augment training sets for few-shot medical image classification, but not all generated samples are equally useful for the downstream task.
arXiv:2607. 18882v1 Announce Type: cross Abstract: Validating Explainable Artificial Intelligence (XAI) methods in medical imaging requires ground-truth data with known locations of informative features.
arXiv:2607. 04401v1 Announce Type: cross Abstract: How robust and generalisable are pathology foundation models and have their scaling limites been reached?
arXiv:2604. 19191v2 Announce Type: replace-cross Abstract: Deploying AI-based anomaly detection across diverse clinical imaging settings remains challenging because most existing methods rely on modality-specific architectures, anatomical priors, or extensive retraining, limiting their use as general-purpose screening tools.
The paper presents a systematic evaluation of six unsupervised image‑to‑image generative models for virtual Sirius Red staining of mouse liver tissue from routine H&E slides. It benchmarks these models across 54 scaling configurations on a newly released paired H&E‑to‑SR dataset, assessing perceptual, distributional, and task‑specific performance, and further trains the best models into deep ensembles to quantify epistemic uncertainty. The study finds that GAN‑based and diffusion‑based methods differ markedly across these metrics, indicating that reliable virtual staining requires reporting and selecting on all three axes simultaneously.
Validating Explainable Artificial Intelligence (XAI) methods in medical imaging requires ground-truth data with known locations of informative features. However, current approaches rely on expert annotations, which are prone to labeling errors, or on hand-crafted artificial perturbations superimposed onto healthy images to mimic lesions or malignant features, which lack clinical realism.