Validating Explainable Artificial Intelligence (XAI) methods in medical imaging requires ground-truth data with known locations of informative features. However, current approaches rely on expert annotations, which are prone to labeling errors, or on hand-crafted artificial perturbations superimposed onto healthy images to mimic lesions or malignant features, which lack clinical realism.
arXiv:2606. 28684v1 Announce Type: cross Abstract: Causally linking disease-related factors to image-derived biomarkers provides a powerful pathway to understanding disease mechanisms.
By Eryn Libert-Scott, Emma A. M. Stanley, Vibujithan Vigneshwaran, Matthias Wilms, Erik Y. Ohara, Nils D. Forkert
arXiv:2606. 18354v1 Announce Type: cross Abstract: Recent advances in generative machine learning models have significantly improved medical imaging, offering promising solutions for data augmentation, privacy preservation, and improved model generalization.
By Muge Zhang, Muhammad Ali Khaliq, Jamal Alsakran, Byeong Kil Lee, Jeeho Ryoo
arXiv:2606. 15457v1 Announce Type: cross Abstract: 3D FLAIR MRI is widely recommended as one of the standard MRI sequences for brain imaging in multiple sclerosis (MS), but publicly available MS datasets remain relatively small and vary across scanners, acquisition protocols, and lesion patterns.
By Weidong Zhang, Yongchan Jung, Shafayat Mowla Anik, Furen Xiao, Vasudevan Janarthanan, Enkhzaya Chuluunbaatar, Byeong Kil Lee, Jeeho Ryoo
arXiv:2608. 03990v1 Announce Type: new Abstract: Synthetic histopathology image generation has emerged as an approach that may address data scarcity in computational pathology, yet current evaluation methodologies may not fully assess synthetic data quality for medical applications.
By Seyed Kahaki, Shijie Li, Weijie Chen, Nicholas Petrick
arXiv:2604. 27277v3 Announce Type: replace-cross Abstract: Brain MRI underpins a wide range of neuroscientific and clinical applications, yet most learning-based methods remain task-specific and require substantial labeled data.
By Yizhou Wu, Shansong Wang, Yuheng Li, Mojtaba Safari, Mingzhe Hu, Chih-Wei Chang, Harini Veeraraghavan, Xiaofeng Yang
arXiv:2601. 08127v2 Announce Type: replace-cross Abstract: Expert-annotated training data remains the critical bottleneck for AI in histopathology, particularly for rare pathologies where even dozens of cases may be unavailable.
By Mohamad Koohi-Moghadam, Mohammad-Ali Nikouei Mahani, Rex K. H. Au-Yeung, Raymond Yu O, Monalyn Marabi, Piyapharom Intarawichian, Fabian Z. X. Lean, Andrew Ferguson, Kyongtae Tyler Bae
arXiv:2606. 11107v1 Announce Type: cross Abstract: Clinicians diagnose brain tumors by synthesizing patient symptoms, medical history, and quantitative imaging data from modalities such as MRI and CT scans into a unified clinical judgement.
By Wajih ul Islam, Muhammad Yaqoob, Javed Ali Khan, Volker Steuber
arXiv:2607. 17782v1 Announce Type: cross Abstract: Foundation models pretrained using self-supervised learning have transformed computer vision by learning transferable representations from large-scale unlabeled data.
By Moona Mazher, Abdul Qayyum, Steven A. Niederer, Daniel C. Alexander
arXiv:2601. 20503v2 Announce Type: replace-cross Abstract: White matter hyperintensities (WMH) and ischaemic stroke lesions (ISL) are key imaging biomarkers of cerebral small vessel disease (SVD) detectable on magnetic resonance imaging (MRI).
By Jesse Phitidis, Alison Q. Smithard, William N. Whiteley, Joanna M. Wardlaw, Miguel O. Bernabeu, Maria Vald\'es Hern\'andez
arXiv:2606. 27405v1 Announce Type: cross Abstract: Deep learning has shown significant potential in medical image analysis, particularly for disease detection using MRI scans.
By Annapurna V K, Asha N, K Paramesha, Shabana Sultana, Kirankumar Humse
arXiv:2606. 07381v1 Announce Type: cross Abstract: Background and Purpose: Automated detection of focal cortical dysplasia (FCD) requires large volumes of voxelwise lesion-delineated MRI data, which are difficult to acquire.
By Prabhjot Kaur, Hakim Ouaalam, Sedat Kandemirli, Sanjay P. Prabhu, Simon K. Warfield