InstEditSeg is a generative framework that treats medical segmentation as an instruction-driven image editing task. Instead of producing binary masks, it renders a color-coded overlay on the original image guided by textual instructions, leveraging latent diffusion models to align with natural image distributions and reduce domain gaps. The method incorporates a DINOv3 visual encoder and a multi-scale feature pyramid fused into the diffusion U‑Net, and uses a dual‑branch classifier‑free guidance strategy to lower inference cost, achieving competitive accuracy on polyp and skin lesion datasets while improving cross‑domain generalization and multi‑lesion segmentation.
By Ziquan Liu, Zhewei Zhu, Xuyang Shi
arXiv:2608. 03990v1 Announce Type: new Abstract: Synthetic histopathology image generation has emerged as an approach that may address data scarcity in computational pathology, yet current evaluation methodologies may not fully assess synthetic data quality for medical applications.
By Seyed Kahaki, Shijie Li, Weijie Chen, Nicholas Petrick
arXiv:2601. 08127v2 Announce Type: replace-cross Abstract: Expert-annotated training data remains the critical bottleneck for AI in histopathology, particularly for rare pathologies where even dozens of cases may be unavailable.
By Mohamad Koohi-Moghadam, Mohammad-Ali Nikouei Mahani, Rex K. H. Au-Yeung, Raymond Yu O, Monalyn Marabi, Piyapharom Intarawichian, Fabian Z. X. Lean, Andrew Ferguson, Kyongtae Tyler Bae
arXiv:2609.24116v1 Announce Type: new
Abstract: Although deep learning has advanced Whole Slide Image (WSI) Analysis, tissue artifacts like bubbles and folds often cause silent failures by concealing...
By Hyeseong Lee, Eunsu Kim, D M Bappy, Ho Heon Kim, Youngsuk Lee, Se Young Chun, Jang-Hwan Choi, Sung Hak Lee, Sangjeong Ahn
arXiv:2606. 24430v1 Announce Type: cross Abstract: Training of neural networks for histopathology classification tasks typically relies on data encoding into latent space, which reduces complexity and improves performance.
By Christian Z\"ollner (Department of Applied Tumor Biology Institute of Pathology Heidelberg University Hospital), Mozzam Motiwala (Department of Applied Tumor Biology Institute of Pathology Heidelberg University Hospital), Aysel Ahadova (Department of Applied Tumor Biology Institute of Pathology Heidelberg University Hospital), Gerrit Anders (Leibniz Institut f\"ur Wissensmedien), Robert H\"uneburg (National Center for Hereditary Tumor Syndromes University Hospital Bonn, Department of Internal Medicine I University Hospital Bonn), Jacob Nattermann (National Center for Hereditary Tumor Syndromes University Hospital Bonn, Department of Internal Medicine I University Hospital Bonn), Matthias Kloor (Department of Applied Tumor Biology Institute of Pathology Heidelberg University Hospital)
arXiv:2607. 14703v1 Announce Type: cross Abstract: Multiple instance learning (MIL) has become the main paradigm for whole-slide image (WSI) analysis in computational pathology.
By Mingxi Fu, Jiawen Li, Renao Yan, Jiali Hu, Qiehe Sun, Tian Guan, Yonghong He
arXiv:2601.17228v2 Announce Type: replace
Abstract: Deep learning models in computational pathology often fail to generalize across cohorts and institutions due to domain shift. Existing approaches e...
By Tengyue Zhang, Ruiwen Ding, Luoting Zhuang, Yuxiao Wu, Erika F. Rodriguez, William Hsu
arXiv:2606. 26712v1 Announce Type: cross Abstract: Skin lesion segmentation is a key task in computer-aided dermatological diagnosis, where accuracy directly impacts downstream analysis and disease classification.
By Jingjun Gu, Chaojie Shen, Yifeng Cao, Wei Zhang, Yiliu Li, Aobo Fan
The paper introduces an unsupervised approach to medical image segmentation by training a Denoising Diffusion Probabilistic Model (DDPM) on 21 unlabeled abdominal CT scans to learn anatomical features. The encoder weights from the DDPM are transferred to a U‑Net for downstream segmentation on the BTCV multi‑organ dataset, resulting in a significant Dice score improvement for liver segmentation from 0.75 to 0.93. In low‑data regimes, diffusion‑pretrained models retain robust performance, achieving high Dice scores even with only 10% of labeled data.
By Akshat G, Divyansh Gupta, Shaleen Bhatnagar, Shilpa Ankalaki, Tusar Kanti Mishra
arXiv:2608.22619v1 Announce Type: cross
Abstract: Generative segmentation provides an alternative to direct pixel-wise prediction by operating on learned latent representations, but effective image-t...
By Md Maklachur Rahman, Md Hasan Al Banna, Saraf Anjum, Mahmudul Hasan, Tracy Hammond
arXiv:2607. 03103v1 Announce Type: cross Abstract: Clinical cardiac imaging pipelines currently deploy separate models for each dataset and modality, incurring redundant training costs and precluding knowledge sharing across anatomically related tasks.
By Jiahao Liu, Hang Wei, Shuai Wu
The paper presents a 3D foundation model for light sheet fluorescence microscopy (LSM) that is pretrained on a large curated set of 3D images from various organisms, stains, and imaging protocols. By jointly optimizing for masked reconstruction and image‑text alignment, the model learns transferable volumetric representations that dramatically reduce the need for annotated data. The pretrained backbone enables efficient few‑shot adaptation to downstream tasks such as segmentation, classification, and deblurring, consistently outperforming baselines according to standard metrics and expert evaluation.
By Adina Scheinfeld, Haotan Zhang, Shang Mu, Rudolf L. M. van Herten, Lucas Stoffl, Ali Erturk, Zhuhao Wu, Johannes C. Paetzold