arXiv:2607. 19137v1 Announce Type: cross Abstract: Inferring contrast enhancement from one pre-contrast breast MRI slice is underdetermined: post-contrast appearance contains physiological information that is not uniquely encoded in baseline anatomy.
arXiv:2607. 29394v1 Announce Type: cross Abstract: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is essential for breast cancer management, but reliance on gadolinium-based contrast agents (GBCAs) restricts use in contraindicated populations, prolongs scan protocols, and presents environmental toxicity concerns.
Inferring contrast enhancement from one pre-contrast breast MRI slice is underdetermined: post-contrast appearance contains physiological information that is not uniquely encoded in baseline anatomy. Optimizing only paired pixel fidelity can suppress uncertain lesion enhancement, whereas adversarial or stochastic generative objectives can favor realistic post-contrast appearance without guaranteeing patient-specific lesion fidelity.
The study presents an anatomy-aware deep learning framework that generates post-contrast breast MRI from pre-contrast images, focusing on tumor and background parenchymal enhancement regions. Using a dataset of 649 patients and 6,251 image pairs, the model incorporates breast mask consistency, lesion-region supervision, and BPE-region supervision within an image-to-image translation architecture. Quantitative metrics, a radiologist reader study, and Ki‑67 classification experiments demonstrate that the proposed method surpasses Pix2Pix, Pix2PixHD, diffusion-based synthesis, and mask-supervised baselines, while Ki‑67 performance remains comparable between real and synthetic images.
The paper introduces MAMA-FLUX.2, a conditional latent flow‑matching model built on FLUX.2-Klein-4B, designed to synthesize post‑contrast breast DCE‑MRI from pre‑contrast images for the MAMA‑SYNTH challenge. It encodes the pre‑contrast image as spatial conditioning and predicts the flow field for the post‑contrast latent, adapting the pretrained model with LoRA fine‑tuning and a regional training objective that combines global flow matching, tumor‑region supervision, and stable foreground regularization. Ablation studies show that moderate tumor and stable‑foreground weighting improves the balance between image fidelity and tumor‑region accuracy, with the best configuration achieving a strong trade‑off using LoRA rank 64/64, MHA_max 25, λ_tumor 0.25, and λ_stable 0.1.
arXiv:2606. 24313v1 Announce Type: new Abstract: AI-driven image-to-image synthesis is rapidly advancing, with growing applications in medical imaging.
arXiv:2603. 01250v2 Announce Type: replace-cross Abstract: Breast cancer is the most frequently diagnosed malignancy among women worldwide and a leading cause of cancer-related mortality.
Team FME submitted a method for the MAMA-MIA Challenge that tackles primary tumor segmentation and pathological complete response (pCR) prediction using dynamic contrast‑enhanced breast MRI. For segmentation, they employed a five‑fold residual‑encoder nnU‑Net ensemble trained on the first post‑contrast minus pre‑contrast image, augmented with mirroring test‑time augmentation and largest‑connected‑component filtering, achieving a Dice score of 0.713 and a normalized Hausdorff distance of 0.099. For pCR prediction, they ensembled 25 pretrained 3D video classifiers on lesion‑centred crops from the pre‑contrast and first two post‑contrast volumes, reaching a balanced accuracy of 0.541 and an equalized‑odds disparity of 0.212, and ranked second in both tasks.
AI-driven image-to-image synthesis is rapidly advancing, with growing applications in medical imaging. Multi-modal image analysis plays a crucial role in optimizing examination quality, yet acquiring multiple imaging modalities in clinical settings remains resource-intensive and time-consuming, especially for 3D imaging.
arXiv:2606. 28980v1 Announce Type: cross Abstract: Ovarian cancer is frequently diagnosed at an advanced stage, making preoperative contrast-enhanced computed tomography (CT) central to staging and surgical planning; yet the scarcity of annotated imaging data, compounded by privacy regulations, limits the development of generalizable computational models in this domain.
arXiv:2511. 15968v2 Announce Type: replace-cross Abstract: External validation of breast ultrasound segmentation models remains limited because internal train--test splits do not capture domain shifts across imaging systems, acquisition protocols, and patient populations.
arXiv:2606. 18354v1 Announce Type: cross Abstract: Recent advances in generative machine learning models have significantly improved medical imaging, offering promising solutions for data augmentation, privacy preservation, and improved model generalization.