Inferring contrast enhancement from one pre-contrast breast MRI slice is underdetermined: post-contrast appearance contains physiological information that is not uniquely encoded in baseline anatomy. Optimizing only paired pixel fidelity can suppress uncertain lesion enhancement, whereas adversarial or stochastic generative objectives can favor realistic post-contrast appearance without guaranteeing patient-specific lesion fidelity.
arXiv:2609.22397v1 Announce Type: cross
Abstract: Purpose: Contrast-enhanced breast MRI depends on intravenous gadolinium-based contrast agents, motivating methods that synthesise post-contrast appea...
By Shohei Yoshimoto
The study presents an anatomy-aware deep learning framework that generates post-contrast breast MRI from pre-contrast images, focusing on tumor and background parenchymal enhancement regions. Using a dataset of 649 patients and 6,251 image pairs, the model incorporates breast mask consistency, lesion-region supervision, and BPE-region supervision within an image-to-image translation architecture. Quantitative metrics, a radiologist reader study, and Ki‑67 classification experiments demonstrate that the proposed method surpasses Pix2Pix, Pix2PixHD, diffusion-based synthesis, and mask-supervised baselines, while Ki‑67 performance remains comparable between real and synthetic images.
By Zhengbo Zhou, Dooman Arefan, Lin Gu, Ufara Zuwasti Curran, Shandong Wu
arXiv:2607. 29394v1 Announce Type: cross Abstract: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is essential for breast cancer management, but reliance on gadolinium-based contrast agents (GBCAs) restricts use in contraindicated populations, prolongs scan protocols, and presents environmental toxicity concerns.
By Smriti Joshi, Apostolia Tsirikoglou, Daniel M. Lang, Richard Osuala, Noah M\'arquez Varaa, Alejandro Guzman, Grzegorz Skorupko, Sebastian Ibarra Arregui, Lidia Garrucho, Akane Ohashi, Dimitra Ntoula, Eugen Divjak, O\u{g}uz Lafc{\i}, Jan C. Peeken, Julia A. Schnabel, Fredrik Strand, Oliver Diaz, Karim Lekadir
The paper introduces MAMA-FLUX.2, a conditional latent flow‑matching model built on FLUX.2-Klein-4B, designed to synthesize post‑contrast breast DCE‑MRI from pre‑contrast images for the MAMA‑SYNTH challenge. It encodes the pre‑contrast image as spatial conditioning and predicts the flow field for the post‑contrast latent, adapting the pretrained model with LoRA fine‑tuning and a regional training objective that combines global flow matching, tumor‑region supervision, and stable foreground regularization. Ablation studies show that moderate tumor and stable‑foreground weighting improves the balance between image fidelity and tumor‑region accuracy, with the best configuration achieving a strong trade‑off using LoRA rank 64/64, MHA_max 25, λ_tumor 0.25, and λ_stable 0.1.
By Kamil Kwarciak, Marek Wodzinski
arXiv:2606. 15457v1 Announce Type: cross Abstract: 3D FLAIR MRI is widely recommended as one of the standard MRI sequences for brain imaging in multiple sclerosis (MS), but publicly available MS datasets remain relatively small and vary across scanners, acquisition protocols, and lesion patterns.
By Weidong Zhang, Yongchan Jung, Shafayat Mowla Anik, Furen Xiao, Vasudevan Janarthanan, Enkhzaya Chuluunbaatar, Byeong Kil Lee, Jeeho Ryoo
Team FME submitted a method for the MAMA-MIA Challenge that tackles primary tumor segmentation and pathological complete response (pCR) prediction using dynamic contrast‑enhanced breast MRI. For segmentation, they employed a five‑fold residual‑encoder nnU‑Net ensemble trained on the first post‑contrast minus pre‑contrast image, augmented with mirroring test‑time augmentation and largest‑connected‑component filtering, achieving a Dice score of 0.713 and a normalized Hausdorff distance of 0.099. For pCR prediction, they ensembled 25 pretrained 3D video classifiers on lesion‑centred crops from the pre‑contrast and first two post‑contrast volumes, reaching a balanced accuracy of 0.541 and an equalized‑odds disparity of 0.212, and ranked second in both tasks.
By Kai Geissler, Raphael Sch\"afer
arXiv:2607. 22727v1 Announce Type: cross Abstract: Medical image segmentation models often report high benchmark accuracy under ideal imaging conditions, yet their failures under clinical degradation can be quiet: sensor noise, patient motion, low- resolution acquisition, and contrast variability may all alter model behavior without producing an obvious warning.
By Pranav Kaliaperumal, Manisha Kaliaperumal
arXiv:2605.05522v3 Announce Type: replace-cross
Abstract: Although self-supervised pretraining is expected to learn broadly transferable representations, its effectiveness across imaging modalities s...
By Aneesh Rangnekar, Joao Miranda, Natally Horvat, Stephanie Chahwan, Samir Alrayess, Aditya Apte, Aditi Iyer, Eve LoCastro, Revathi Ravella, Marc J Gollub, Iva Petkovska, Jesse Joshua Smith, Paul Romesser, Julio Garcia-Aguilar, Harini Veeraraghavan, Joseph O Deasy
arXiv:2608.28787v1 Announce Type: new
Abstract: Joint-embedding predictive architectures (JEPAs) have primarily been developed for self-supervised representation learning. Denoising JEPA (D-JEPA) rec...
By Meng Zhou, Wenhao You, Yuxing Chen, Yueying Tian
arXiv:2511. 15968v2 Announce Type: replace-cross Abstract: External validation of breast ultrasound segmentation models remains limited because internal train--test splits do not capture domain shifts across imaging systems, acquisition protocols, and patient populations.
By Jingru Zhang, Saed Moradi, Ashirbani Saha
arXiv:2606. 18354v1 Announce Type: cross Abstract: Recent advances in generative machine learning models have significantly improved medical imaging, offering promising solutions for data augmentation, privacy preservation, and improved model generalization.
By Muge Zhang, Muhammad Ali Khaliq, Jamal Alsakran, Byeong Kil Lee, Jeeho Ryoo