VGG16-MCA UNet is a hybrid neural network that combines an ImageNet‑pretrained VGG16 encoder with a decoder enhanced by a Multi‑Channel Attention module, trained using Focal Tversky loss to address class imbalance. The model was evaluated as a 2‑D, FLAIR‑only whole‑tumor segmenter on BraTS 2020 and LGG datasets, achieving a pixel‑level Dice of 95.10 % on BraTS and 88.32 % on LGG in a 5‑fold cross‑validation setting. Inference time is 66.32 ms per 256×256 slice on a single RTX 2060, only slightly slower than a VGG16‑UNet without attention.
whyItMatters":"The study provides a reproducible 2‑D FLAIR baseline for whole‑tumor segmentation, demonstrating high Dice scores and detailed reporting of training and evaluation protocols."
By Shubham Gajjar, Deep Joshi, Avi Poptani, Vishal Barot
arXiv:2607. 01001v1 Announce Type: cross Abstract: Radiomics is the established approach for CT-based lung cancer phenotyping, yet comparisons with foundation models rarely isolate contributions of feature extractor, classification head, and segmentation choice, or test cross-cohort robustness.
By Nils Neukirch, Martin Maurer, Nils Strodthoff
Team FME submitted a method for the MAMA-MIA Challenge that tackles primary tumor segmentation and pathological complete response (pCR) prediction using dynamic contrast‑enhanced breast MRI. For segmentation, they employed a five‑fold residual‑encoder nnU‑Net ensemble trained on the first post‑contrast minus pre‑contrast image, augmented with mirroring test‑time augmentation and largest‑connected‑component filtering, achieving a Dice score of 0.713 and a normalized Hausdorff distance of 0.099. For pCR prediction, they ensembled 25 pretrained 3D video classifiers on lesion‑centred crops from the pre‑contrast and first two post‑contrast volumes, reaching a balanced accuracy of 0.541 and an equalized‑odds disparity of 0.212, and ranked second in both tasks.
By Kai Geissler, Raphael Sch\"afer
L2GSSL is a self‑supervised learning framework designed for volumetric healthcare data, particularly CT scans. It decomposes pretraining into intra‑slice and inter‑slice representation spaces, using a slice encoder for local, view‑invariant features and a global encoder to aggregate tokens for volumetric context. On the LIDC‑IDRI lung nodule malignancy classification task, L2GSSL achieves high AUROC scores with only 10–25% of labels, outperforming other self‑supervised baselines and approaching the performance of fully supervised models.
By Po-Cheng Cheng, Hung-Hsuan Chen
The paper presents a pragmatic segmentation pipeline for brain metastases in the BraTS 2026 Task 1, using a 5‑fold nnU-Net ResEnc‑L ensemble trained for 1,000 epochs on 1,296 four‑modality cases. A rule‑based post‑processing cascade tuned for the lesion‑wise Dice similarity coefficient (LW‑DSC) improves performance, achieving LW‑DSC scores of 0.733, 0.751, 0.713, and 0.549 on enhancing tumour, tumour core, whole tumour, and resection cavity, respectively. The authors audit each post‑processing stage with a five‑fold out‑of‑fold analysis, confirm two stages as robust, and provide a mechanistic analysis of LW‑DSC, along with thirteen negative results that challenge common intuitions.
arXiv:2607. 25164v1 Announce Type: cross Abstract: A CT examination captures multiple organs, but many biomedical questions concern abnormalities, prognosis, or longitudinal change in a specific organ.
By Zhixuan Ge, Anqi Li, Sadeer Al-Kindi, Hanwen Xu, Wei Qiu
arXiv:2609.01554v1 Announce Type: cross
Abstract: Automated lesion segmentation in whole-body PET/CT is complicated by the variety of physiological tracer uptake patterns and by the differing appeara...
By Marven Sherif (Brightskies), Amgad Elmasry (Brightskies), Youssef Ghazal (Brightskies), Ayman Elghotni (Brightskies)
arXiv:2606. 28392v1 Announce Type: cross Abstract: Accurate lesion segmentation in PET/CT is critical for oncology, yet remains challenging because physiologic tracer uptake and artifacts can mimic malignant signal.
By Jiasheng Wang, Tanun Jitwatcharakomol, Piyawadee Jongpradubgiat, Simeng Zhu
A specialized large multimodal model, LLaVA‑NeXT, was fine‑tuned on a curated two‑level curriculum of PET/CT image‑conversation pairs to interpret head and neck cancer scans. In external validation across four institutions, the model achieved high ROUGE and similarity scores and outperformed generalist models such as ChatGPT, with primary tumor classification accuracy of 83.14% internally and 69.03% externally. The study demonstrates that domain‑specific LMMs can provide fast, accurate diagnostic support for PET/CT imaging.
By Haengbok Chung, SunGyu Kim, Joo hyun Lee, Sangjin Bae, Min Jeong Cho, Minseok Suh, Jae Sung Lee
The paper presents a segmentation pipeline for brain metastases in both pre‑ and post‑treatment cases using a 5‑fold nnU‑Net ResEnc‑L ensemble trained on 1,296 four‑modality cases. A rule‑based post‑processing cascade improves the lesion‑wise Dice similarity coefficient (LW‑DSC) for enhancing tumour, tumour core, whole tumour, and resection cavity sub‑regions, achieving LW‑DSC scores of 0.733, 0.751, 0.713, and 0.549 respectively on the official validation leaderboard. The authors conduct a five‑fold out‑of‑fold analysis to validate the robustness of each post‑processing stage, provide a mechanistic explanation of LW‑DSC behaviour, and report thirteen negative results that challenge common intuitions, with all code released under Apache‑2.0.
By Haobin Liu, Xin Wang
arXiv:2609.24769v1 Announce Type: new
Abstract: Brain metastases are the most common intracranial malignancy, occurring in roughly 30% of patients with primary solid tumors and carrying a median surv...
By Mahdi Islam, Musarrat Tabassum
The paper introduces TAP-JEPA, a joint‑embedding predictive architecture trained on over 113,000 CT volumes, which achieves performance comparable to leading encoders in scan‑level classification. It demonstrates a predictability bias: while anatomy is largely predictable from context, pathology is not, leading to significant degradation in pathology detection when predictions are applied. The study audits the model’s predictive pathway, showing that pathology representations shift toward control regions and that removing pathology tokens minimally affects downstream decisions, underscoring that contextual predictability alone is insufficient for clinical relevance.
By Fabian Drexel, Bernhard Kainz, Jakob N. Kather, Daniel Rueckert, Lisa C. Adams, Keno K. Bressem, Cosmin I. Bercea