This study presents a clinically relevant framework for evaluating deep neural networks that segment lymphoma lesions in PET/CT images, addressing gaps such as out‑of‑distribution testing and comparison with expert annotators. Using 611 multi‑institutional cases, the authors assess four networks (ResUNet, SegResNet, DynUNet, SwinUNETR) with lesion‑specific metrics, detection criteria, and metabolic‑characteristic‑based thresholds, finding that models perform best on large, intense lesions. The work also demonstrates that network errors mirror those of physicians, highlighting shared challenges with small, faint lesions.
By Shadab Ahamed, Yixi Xu, Sara Kurkowska, Claire Gowdy, Joo H. O, Ingrid Bloise, Don Wilson, Patrick Martineau, Fran\c{c}ois B\'enard, Fereshteh Yousefirizi, Rahul Dodhia, Juan M. Lavista, William B. Weeks, Carlos F. Uribe, Arman Rahmim
arXiv:2606. 28392v1 Announce Type: cross Abstract: Accurate lesion segmentation in PET/CT is critical for oncology, yet remains challenging because physiologic tracer uptake and artifacts can mimic malignant signal.
By Jiasheng Wang, Tanun Jitwatcharakomol, Piyawadee Jongpradubgiat, Simeng Zhu
arXiv:2608. 07857v1 Announce Type: cross Abstract: Foundation models provide transferable CT representations, but predictions based directly on these embeddings are difficult to interpret.
By Fakrul Islam Tushar, Stephen Adamo, Geoffrey D. Rubin
arXiv:2608. 19666v1 Announce Type: new Abstract: Deep learning-based whole-body PET-CT lesion segmentation can support cancer staging, treatment planning, and response assessment, but generalization is limited by scarce annotations and domain shifts.
By Bashirul Azam Biswas, Amartya Bhattacharya, Biratal Raj Wagle, Matthew E. Maeder, James B. Yu, Indrani Bhattacharya
arXiv:2608.30021v1 Announce Type: cross
Abstract: Errors in radiology reports can adversely affect patient treatment, yet automated report quality assurance remains challenging because errors are oft...
By Hermione Warr, Harry Anthony, Lilli J Freischem, Yasin Ibrahim, Daniel R McGowan, Konstantinos Kamnitsas
Background: Early prediction of distant metastasis (DM) risk in head and neck cancer (HNC) can enable timely interventions that may improve treatment outcomes. Many current machine learning methods rely on prior knowledge of the region of interest such as tumor segmentations, which require expert knowledge, is time-consuming and introduces user-dependent variability.