arXiv AI

Multi-Modal Graph Neural Network with Transformer-Guided Adaptive Diffusion for Preclinical Alzheimer Classification

arXiv:2606. 03322v1 Announce Type: cross Abstract: The graphical representation of the brain offers critical insights into diagnosing and prognosing neurodegenerative disease via relationships between regions of interest (ROIs).

arXiv AI
Jun 15

GMN4AD: Graph Matching Network for Alzheimer's Disease Diagnosis with Test-Time Domain Adaptation using Multi-centered Structure Magnetic Resonance Imaging

arXiv:2606. 13919v1 Announce Type: cross Abstract: Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that affects millions of older adults, with prevalence expected to rise significantly in the coming years.

By Chen Zhao, Huan Huang, Yixin Xie, Jiajing Huang, Weihua Zhou, Nandakumar Narayanan
arXiv Machine Learning
Jun 25

SDE-Driven Spatio-Temporal Hypergraph Neural Networks for Irregular Longitudinal fMRI Connectome Modeling in Alzheimer's Disease

arXiv:2603. 20452v2 Announce Type: replace Abstract: Longitudinal neuroimaging is essential for modeling disease progression in Alzheimer's disease (AD), yet irregular sampling and missing visits pose substantial challenges for learning reliable temporal representations.

By Ruiying Chen, Yutong Wang, Houliang Zhou, Wei Liang, Yong Chen, Lifang He
arXiv Machine Learning
Sep 18

HyperAMS-Net: Adaptive Multi-Scale Spatial Hypergraph Network for Brain Disorder Classification

HyperAMS‑Net is a deep learning framework that classifies brain disorders from resting‑state fMRI or structural MRI data. It combines adaptive multi‑scale convolution, hypergraph attention, spatial‑channel attention, and adaptive feature fusion to capture complementary patterns across multiple scales and higher‑order dependencies. Evaluated on ABIDE, REST‑meta‑MDD, and ADNI datasets, it achieves state‑of‑the‑art accuracy and AUC, with ablation studies showing hypergraph attention as the most critical component.

By Proloy Kumar Mondal, Md Kamran Hussin Chowdhury, Hoi Leong Lee
arXiv Machine Learning
Sep 16

Explainable Graph-theoretical Machine Learning with Application to Alzheimer's Disease Prediction

The paper introduces Explainable Graph-theoretical Machine Learning (XGML) to build individual metabolic brain graphs from FDG-PET data and identify subgraphs predictive of multivariate Alzheimer’s disease outcomes. Using ADNI data, the best model—kernel density estimation with Hellinger distance and random forest—achieved a Pearson correlation of 0.595 across eight cognitive scores, with the highest performance on ADAS13, ADAS11, and ADASQ4. Key edges were found to be jointly but differentially predictive, indicating potential network biomarkers for cognitive decline, though external validation on OASIS3 showed weaker performance likely due to cohort differences.

By Narmina Baghirova, Duy-Thanh V\~u, Duy-Cat Can, Christelle Schneuwly Diaz, Julien Bodlet, Guillaume Blanc, Georgi Hrusanov, Bernard Ries, Oliver Y. Ch\'en
arXiv Machine Learning
Jul 23

Geometry-Guided Generative Representation for Functional Brain Graphs

arXiv:2511. 04539v2 Announce Type: replace-cross Abstract: In network neuroscience, functional brain systems are often characterized using separate yet related graph-theoretic or spectral descriptors, overlooking how these properties covary and partially overlap across individuals and conditions.

By Subati Abulikemu, Tiago Azevedo, Michail Mamalakis, John Suckling