arXiv Machine Learning

Subtyping patients with chronic disease using longitudinal BMI patterns

arXiv:2111. 05385v3 Announce Type: replace Abstract: Obesity is a major health problem, increasing the risk of various major chronic diseases, such as diabetes, cancer, and stroke.

arXiv Machine Learning
Jun 5

A Machine Learning-Based Framework for Discovering Huntington's Disease Stages: Integrating Graph Representation Learning and clustering to Uncover Progression Dynamics in Longitudinal Enroll-HD Dataset

arXiv:2606. 06196v1 Announce Type: new Abstract: Huntington's disease (HD) is a progressive brain disorder that gradually affects movement, cognitive function, and behavior.

By Lubna M. Abu Zohair, Marta Vallejo, MD Azher Uddin, John R. Woodward, Hind Zantout
arXiv Machine Learning
Aug 26

A Structural FHMM for Interpretable Disease Trajectories in T2DM

arXiv:2608.24328v1 Announce Type: new Abstract: In this work, we propose a structural variant of the Factorial Hidden Markov Model (FHMM) for the analysis of disease trajectories in patients with Typ...

By Alessandro Mari, Ekaterina Krymova, Guillaume Obozinski, Maria Luisa Marques de Sa Faquetti, Adrian Martinez de la Torre, Andrea Burden
arXiv Machine Learning
Sep 1

Learning Human Health and Diseases from 24-hour Wrist Movement

The paper introduces Sensori, a self‑supervised foundation model that learns health representations from 24‑hour raw tri‑axial wrist movement data. Trained on 122,640 participants across the UK, China, and the US, Sensori captures diverse movement behaviours, demographics, health axes, and physical function. In independent cohorts, the model improved disease classification for 52 of 102 conditions and incident disease risk prediction for 26 of 87 conditions, especially for neurological and psychiatric disorders.

By Yong Wang, Dylan McGagh, Katya Broomberg, Zizheng Zhang, Jonathan Carter, Junayed Naushad, Laura Brocklebank, Yang Sun, George Nicholson, Dianjianyi Sun, Canqing Yu, Jun Lv, Maxim Barnard, Hubert Lam, Andrew Steptoe, David W. Eyre, Liming Li, Zhengming Chen, Naomi Wray, Spiros Denaxas, Gary S. Collins, Huaidong Du, Aiden Doherty, Hang Yuan
arXiv Machine Learning
Jun 8

Explaining Unsupervised Disease Staging in Huntington's Disease: Insights into Model Representations and Clusters

arXiv:2606. 07135v1 Announce Type: new Abstract: Huntington's disease (HD) is a progressive neurodegenerative disorder that affects motor, cognitive, and behavioral functions, where accurate characterization of disease progression remains essential to improve patient outcome and quality of life.

By Lubna Mahmoud Abu Zohair, Hind Zantout
arXiv Machine Learning
Jul 17

A Temporal Machine Learning-Based Time-to-Event Model for Predicting ALS Progression and Healthcare Utilization

arXiv:2607. 14190v1 Announce Type: new Abstract: Amyotrophic lateral sclerosis (ALS) is a progressive and heterogeneous neurodegenerative disease in which predicting clinically meaningful milestones, such as assistive device use, remains challenging.

By Zongliang Yue, Qi Li, Terry Heiman-Patterson, Frank Bearoff, Zhaohui Qin, Huanmei Wu