arXiv AI

Contrastive Representation Learning of Longitudinal Disease Trajectories on Temporal Graphs

arXiv:2607. 25609v1 Announce Type: cross Abstract: Understanding disease trajectories from longitudinal clinical data remains challenging due to complex temporal dynamics and heterogeneous patient cohorts.

arXiv Machine Learning
Jun 5

A Machine Learning-Based Framework for Discovering Huntington's Disease Stages: Integrating Graph Representation Learning and clustering to Uncover Progression Dynamics in Longitudinal Enroll-HD Dataset

arXiv:2606. 06196v1 Announce Type: new Abstract: Huntington's disease (HD) is a progressive brain disorder that gradually affects movement, cognitive function, and behavior.

By Lubna M. Abu Zohair, Marta Vallejo, MD Azher Uddin, John R. Woodward, Hind Zantout
arXiv Machine Learning
Jun 25

SDE-Driven Spatio-Temporal Hypergraph Neural Networks for Irregular Longitudinal fMRI Connectome Modeling in Alzheimer's Disease

arXiv:2603. 20452v2 Announce Type: replace Abstract: Longitudinal neuroimaging is essential for modeling disease progression in Alzheimer's disease (AD), yet irregular sampling and missing visits pose substantial challenges for learning reliable temporal representations.

By Ruiying Chen, Yutong Wang, Houliang Zhou, Wei Liang, Yong Chen, Lifang He
arXiv AI
Sep 17

Hyperbolic Graph Representation Learning for Differential Diagnosis on Biomedical Knowledge Graphs

The paper investigates hyperbolic graph representation learning applied to biomedical knowledge graphs for Mendelian-disease differential diagnosis. It shows that hyperbolic embeddings outperform Euclidean baselines on isolated ontology subgraphs while requiring fewer dimensions. In a link-prediction task, hyperbolic models rank candidate diseases for patients, indicating they can leverage hierarchical structure in heterogeneous patient-level graphs.

By Pietro Miotto, Lucia Mellini, Tommaso Marzi, Cesare Alippi, Elena Casiraghi, Alberto Paccanaro, Giorgio Valentini, Mauricio Soto-Gomez
arXiv AI
Jul 7

Graph Representation Learning of Longitudinal Medical Imaging Trajectories for Treatment Response Prediction

arXiv:2607. 04912v1 Announce Type: cross Abstract: In patients with breast cancer, pathological complete response (pCR) has been established as a clinically meaningful surrogate marker for long-term outcomes.

By Johannes Kiechle, Richard Osuala, Daniel M. Lang, Stefan M. Fischer, Ivana Jan\'i\v{c}kov\'a, Karim Lekadir, Julia A. Schnabel, Jan C. Peeken
arXiv Machine Learning
Sep 21

HERMES: Contrast-Aware Knowledge Graph Reasoning from Clinical Notes for Patient Outcome Prediction

HERMES is a graph-based framework that uses only clinical text to predict patient outcomes. It builds personalized Knowledge Graphs from clinical notes via Large‑Language‑Model‑guided extraction and Contrastive Logic Modeling, capturing temporal dynamics and treatment changes. A Graph Attention Network then synthesizes patient representations, and experiments on MIMIC‑III and MIMIC‑IV show HERMES outperforms text‑only baselines for in‑hospital mortality and 30‑day readmission prediction.

By Gia-Bach Nguyen, Hoang-Ha Nguyen, Tuan-Cuong Vuong, Trang Mai Xuan, Duy Quoc Ngo, Tien-Cuong Nguyen, Huan Vu, Thien Van Luong
arXiv AI
Jun 10

Capture Timing-Attention of Events in Clinical Time Series

arXiv:2602. 10385v5 Announce Type: replace-cross Abstract: The contemporary paradigm of trajectory learning operates fundamentally at the level of group dynamics, systematically reducing individual-level complexity to fit group-level models, thus rendering effective patient subtyping difficult and individual-level modeling largely out of reach.

By Jia Li, Yu Hou, Rui Zhang