ORION‑CMR is a scanner‑native, end‑to‑end foundation model for cardiac MRI that performs sequence classification, ventricular function assessment, LGE detection, disease classification, and generates reports in about 90 seconds. Trained on 12.9 million images, it outperformed supervised baselines and a prior CMR foundation model, achieving state‑of‑the‑art LGE classification and scar segmentation. In a multi‑vendor clinical cohort, it reached an AUC of 0.96 for normal‑vs‑abnormal detection and 0.88 for multiclass disease classification, with generated reports agreeing 81.4% with expert interpretation.
By Omer Burak Demirel, Kelly K. Horst, Alessio Perazzolo, Elisa Bruno, Kenan Kaya, Rongzhen Ouyang, Enas Ahmed, Jouke Smink, Spencer L. Waddle, Zainudeen Kallumpurath, Tzu Cheng Chao, Dinghui Wang, Steve G. Langer, Timothy L. Kline, Panagiotis Korfiatis, Jacinta Browne, Ivana Isgum, Tim Leiner
arXiv:2608.29246v1 Announce Type: cross
Abstract: Late gadolinium enhancement (LGE) cardiac magnetic resonance (MR) imaging is the modality of choice to assess myocardial infarction (MI) lesions. Now...
By Olivier Bernard, William A. Romero R., Cyprien Bouton, Celia Goujat, Hang Jung Ling, Pierre-Marc Jodoin, Fumin Guo, Calder Sheagren, Graham Wright, Abdul Qayyum, Moona Mazher, Steven A. Niederer, Hairui Wang, Xiaomei Wu, Franz Thaler, Gernot Plank, Martin Urschler, Ricardo M. Rosales, Esther Pueyo, Nicolas Duchateau, Frederic Cervenansky, Patrick Clarysse, Loic Belle, Thomas Bochaton, Nathan Mewton, Magalie Viallon, Pierre Croisille
The paper introduces SV-Cine, a cardiac MRI segmentation framework tailored for single ventricle physiology (SVP). It combines a generative data augmentation pipeline that creates synthetic 3D cardiac meshes and MRI, with a diagnosis-conditioned adaptation of the CineMA foundation model that uses patient-level diagnostic information to improve segmentation. Evaluations on an internal cohort show high Dice scores for left and right ventricles, outperforming nnU-Net, and demonstrate that incorporating diagnosis priors can adapt a pretrained model to specialized SVP tasks.
By Lila Cunge, Yuehong Liu, Hang Xu, Thomas Coudert, Pierangelo Renella, J Paul Finn, William Hsu, Kim-Lien Nguyen
CMRVision is a cardiac magnetic resonance (CMR) foundation model trained with DINOv3-style self‑supervised learning on 36 million multi‑center, multi‑sequence CMR images. It outperforms prior natural‑image, medical‑image, supervised, and CMR baselines on multi‑task segmentation (cine, LGE, mapping) and cine view classification, achieving Dice scores of 0.940–0.967 for LV and 0.855–0.905 for myocardium, and a zero‑shot Dice of 0.692 on unseen LGE long‑axis views. The model demonstrates robust cross‑view generalization and highest average accuracy (0.906) for cine view classification.
By Athira J. Jacob, Puneet Sharma, Daniel Rueckert
arXiv:2606. 00123v1 Announce Type: cross Abstract: Multimodal Large Language Models (MLLMs) have shown strong performance on public medical benchmarks, yet existing evaluations often remain weak proxies for clinical use, relying on isolated inputs and simplified recognition-style tasks.
By Zixian Su, Hongkai Zhang, Fan Gao, Encheng Su, Taiping Qu, Jingwei Guo, Nan Zhang, Hui Wang, Zhen Zhou, Kairui Bo, Yan Chen, Yue Ren, Shuai Li, Lei Xu, Henggui Zhang
arXiv:2608.27690v1 Announce Type: cross
Abstract: Cardiovascular risk prediction remains limited by incomplete clinical data and imaging biomarkers that reduce computed tomography (CT) to a small num...
By Roy Gabriel, Nattakorn Kittisut, Jamshid Hassanpour, Michael Galarnyk, Abanoub Abdelmalak, Marly van Assen, Carlo N. De Cecco, Arshed Quyyumi, Ali Adibi
The study demonstrates that contrastive pre‑training of ECG representations using cardiac magnetic resonance (CMR) imaging data can enhance ECG‑based detection of Chagas disease. By aligning an ECG encoder with a CMR embedding space from 63,193 paired UK Biobank examinations, the authors achieved higher AUROC and sensitivity metrics on CODE‑15%, SaMi‑Trop, and PhysioNet/CinC 2025 Challenge datasets compared to an unaligned baseline. The approach shows that imaging‑supervised ECG representations generalize across different populations and resource‑constrained settings.
By Laura Alvarez-Florez, Daniel Uyterlinde, Samuel Ruip\'erez-Campillo, Lukas P. A. Arts, Folkert W. Asselbergs, Fleur V. Y. Tjong
arXiv:2607. 09948v1 Announce Type: cross Abstract: Cardiac amyloidosis (CA) is increasingly recognized but remains substantially underdiagnosed, because its clinical and imaging phenotype overlaps with more common cardiomyopathies.
By Diana Shadibaeva, Rochak Dhakal, Kui Zhang, Xiaofeng Yang, Saurabh Malhotra, Weihua Zhou
The paper presents a two‑stage framework for prenatal congenital heart disease (CHD) screening that operates directly on whole fetal ultrasound studies. It first learns transferable frame representations via self‑supervised masked‑autoencoder pre‑training, then identifies cardiac frames with a disease‑robust module and aggregates them using a transformer‑based multiple instance learning model to produce a case‑level diagnosis. The approach achieves high performance (AUC 0.985, specificity 0.990) on an internal test set and, after label‑free CORAL adaptation, improves to an AUC of 0.944 on an external cohort, outperforming existing baselines.
By Mohamed Azzam, Ruobing Liu, Esther C. Ugwueke, Ziyang Xu, Shibiao Wan, Alex Foy, Abraham Zabih, Jason Christensen, Neil Hamill, Ling Li, Jieqiong Wang
This study introduces a two‑stage vision‑language model framework to assess the clinical quality and usability of late gadolinium enhancement (LGE) cardiac MRI images used for atrial fibrillation ablation planning. The first stage employs a fine‑tuned VLM to generate structured radiology‑style reports on five quality criteria—Noise, Motion Artifact, LA Boundary Accuracy, PV Region Accuracy, and Under‑segmentation Severity—while the second stage uses a GPT‑based reasoning module to convert these reports into structured quality scores and a binary decision on clinical usability. Evaluated on a curated dataset of 60 image‑slice and text‑pair annotations from 20 patients, the InternVL2 model achieved the highest criterion‑level accuracy, and DeepSeek reached perfect agreement on the clinical usability decision.
By Bipasha Kundu, Abhishek Chaturvedi, Axel W. E. Wismueller, Richard Simon, Cristian A. Linte
This study introduces a self‑supervised, physics‑guided deep‑learning framework that converts standard clinical T1‑, T2‑, and FLAIR MRIs into quantitative T1, T2, and proton‑density maps. Trained on 4,121 scan sessions from four different 3 T scanners over six years, the method produces maps whose white‑ and gray‑matter values fall within literature ranges and shows minimal variation across scanner hardware and acquisition protocols (coefficients of variation ≤ 1.1 %). Voxel‑wise reproducibility is high, with Pearson and concordance correlation coefficients above 0.82 for T1 and T2 and mean relative differences below 6 % for T2.
By Jelmer van Lune, Stefano Mandija, Oscar van der Heide, Matteo Maspero, Martin B. Schilder, Jan Willem Dankbaar, Cornelis A. T. van den Berg, Alessandro Sbrizzi
arXiv:2607. 11287v1 Announce Type: cross Abstract: Comprehensive quantification of cardiac structures from computed tomography (CT) remains limited not by data availability but by the scalability of measurements, which makes routine use impractical.
By Pooya Mohammadi Kazaj, Leo Fridolin Weber, Wen Xie, Seyed Amir Ahmad Safavi-Naini, Anselm Stark, Giovanni Baj, Ali Mokhtari, Toshiya Yoshida, Christoph Ryffel, Taishi Okuno, Yoshihiro Akashi, Ronny R. Buechel, Thomas Pilgrim, Waldo Valenzuela, George C. M. Siontis, Xiaowei Xu, Moritz Hundertmark, Stephan Windecker, Christoph Grani, Isaac Shiri