arXiv AI
Aug 24

Fine-tuning an ECG Foundation Model to Predict Coronary CT Angiography Outcomes

A multicenter study developed an AI-enabled electrocardiography (AI-ECG) model that predicts vessel-specific hemodynamically significant stenosis using coronary computed tomographic angiography (CCTA) as the reference. The model demonstrated strong discrimination in internal and external cohorts, including normal ECGs, and produced low-, intermediate-, and high-risk strata that correlated with stenosis severity and major adverse cardiovascular events. Calibration, decision curve analyses, and integration with guideline-based pre-test probability showed clinical utility, while waveform and attribution analyses revealed physiologically meaningful ECG features linked to high-risk predictions.

By Yujie Xiao, Qinghao Zhao, Gongzheng Tang, Hao Zhang, Zhuoran Kan, Deyun Zhang, Jun Li, Guangkun Nie, Xiaocheng Fang, Haoyu Wang, Shun Huang, Tong Liu, Jian Liu, Kangyin Chen, Shenda Hong
arXiv Computer Vision
Aug 27

Auditable CT Phenotyping Through Report-derived Radiological Observations

The study introduces Auditable CT Phenotyping (ACT), a method that uses report-derived radiological observations to predict 221 electronic-health-record phenotypes from CT scans. Trained on 38,317 patients and evaluated on 25,183 held‑out patients, ACT outperformed five vision‑language baselines and CT‑CLIP in both zero‑shot and linear probing settings. Analysis of the model’s probes revealed that a small set of observations, such as aortic and coronary calcification, dominated top predictions, but restricting the observation bank to clinician‑specified evidence improved interpretability without sacrificing accuracy.

By Riga Wu, Walter Witschey, Yicheng Li, Felix Barajas Ordonez, Keno K. Bressem, Lisa C. Adams, Gary E. Weissman, Li Shen, Christos Davatzikos, Eduardo Barbosa, Daniel Truhn, Tianyu Han
arXiv AI
Jul 2

EchoRisk: A Multicentre Echocardiography Dataset and Benchmark for Cardio-Oncology

arXiv:2607. 01039v1 Announce Type: cross Abstract: Therapy-induced cardiotoxicity is the leading non-oncological cause of treatment interruption in breast cancer patients, yet early, automated risk stratification from routine cardiac imaging remains an unsolved problem.

By Grigorios Kalliatakis, Georgia Karanasiou, Georgios Manikis, Manolis Tsiknakis, Dimitrios Fotiadis, Dorothea Tsekoura, Kalliopi Keramida, Vasileios Bouratzis, Lampros Lakkas, Katerina Naka, Andri Papakonstantinou, Anastasia Constantinidou, Kostas Marias
arXiv Machine Learning
Jul 2

Foundation Models vs. Radiomics for Lung Computed Tomography: A Benchmark of Feature Extractors, Classification Heads, and Segmentation Choices

arXiv:2607. 01001v1 Announce Type: cross Abstract: Radiomics is the established approach for CT-based lung cancer phenotyping, yet comparisons with foundation models rarely isolate contributions of feature extractor, classification head, and segmentation choice, or test cross-cohort robustness.

By Nils Neukirch, Martin Maurer, Nils Strodthoff