A multicenter study developed an AI-enabled electrocardiography (AI-ECG) model that predicts vessel-specific hemodynamically significant stenosis using coronary computed tomographic angiography (CCTA) as the reference. The model demonstrated strong discrimination in internal and external cohorts, including normal ECGs, and produced low-, intermediate-, and high-risk strata that correlated with stenosis severity and major adverse cardiovascular events. Calibration, decision curve analyses, and integration with guideline-based pre-test probability showed clinical utility, while waveform and attribution analyses revealed physiologically meaningful ECG features linked to high-risk predictions.
By Yujie Xiao, Qinghao Zhao, Gongzheng Tang, Hao Zhang, Zhuoran Kan, Deyun Zhang, Jun Li, Guangkun Nie, Xiaocheng Fang, Haoyu Wang, Shun Huang, Tong Liu, Jian Liu, Kangyin Chen, Shenda Hong
arXiv:2606. 28179v1 Announce Type: cross Abstract: Identifying robust associations between cardiac imaging phenotypes and clinical diseases is fundamental to population-scale cardiovascular research and reliable risk stratification.
By Zuoou Li, Wenlong Zhao, Kelly Yu, Weitong Zhang, Paul M. Matthews, Wenjia Bai, Bernhard Kainz, Mengyun Qiao
The study introduces Auditable CT Phenotyping (ACT), a method that uses report-derived radiological observations to predict 221 electronic-health-record phenotypes from CT scans. Trained on 38,317 patients and evaluated on 25,183 held‑out patients, ACT outperformed five vision‑language baselines and CT‑CLIP in both zero‑shot and linear probing settings. Analysis of the model’s probes revealed that a small set of observations, such as aortic and coronary calcification, dominated top predictions, but restricting the observation bank to clinician‑specified evidence improved interpretability without sacrificing accuracy.
By Riga Wu, Walter Witschey, Yicheng Li, Felix Barajas Ordonez, Keno K. Bressem, Lisa C. Adams, Gary E. Weissman, Li Shen, Christos Davatzikos, Eduardo Barbosa, Daniel Truhn, Tianyu Han
arXiv:2607. 01039v1 Announce Type: cross Abstract: Therapy-induced cardiotoxicity is the leading non-oncological cause of treatment interruption in breast cancer patients, yet early, automated risk stratification from routine cardiac imaging remains an unsolved problem.
By Grigorios Kalliatakis, Georgia Karanasiou, Georgios Manikis, Manolis Tsiknakis, Dimitrios Fotiadis, Dorothea Tsekoura, Kalliopi Keramida, Vasileios Bouratzis, Lampros Lakkas, Katerina Naka, Andri Papakonstantinou, Anastasia Constantinidou, Kostas Marias
arXiv:2607. 04478v1 Announce Type: cross Abstract: Automated chest X-ray classification remains challenging due to severe class imbalance, co-occurring pathologies, and the loss of localized features in conventional architectures.
By Moshiur Rahman, Shafqat Alam, Tasnia Binte Mamun
arXiv:2607. 01001v1 Announce Type: cross Abstract: Radiomics is the established approach for CT-based lung cancer phenotyping, yet comparisons with foundation models rarely isolate contributions of feature extractor, classification head, and segmentation choice, or test cross-cohort robustness.
By Nils Neukirch, Martin Maurer, Nils Strodthoff
arXiv:2608.21571v1 Announce Type: new
Abstract: Lung cancer remains a leading cause of cancer-related mortality worldwide, and early diagnosis is critical for improving survival. However, early-stage...
By Olivera Kotevska, Ian Goethert, Michael McGee, Maria Mahbub, Sean R. Wilkinson, Rowena Yip, Myvizhi Esai Selvan, Zeynep H. Gumus, Claudia Henschke, Robert J. Klein, Providencia Morales, Samuel M Aguayo, Ioana Danciu, Mayanka Chandrashekar
arXiv:2609.00909v1 Announce Type: new
Abstract: Reliable evaluation of automated coronary computed tomography angiography (CCTA) report generation requires standardized multicentre benchmarks and cli...
By Zhiyu Ye, Yue Sun, Limiao Zou, Cheng Xu, Keting Xu, Tong Hu, Yue Yu, Hairong Zheng, Yining Wang, Tong Zhang
arXiv:2606. 10725v1 Announce Type: new Abstract: Background.
By Olga Shakhmatova, Dmitrii Kriukov, Daniil Larionov, Nikita Khromov, Iaroslav Bespalov, Alexander Zolotarev, Kirill Grishchenkov, Ekaterina Ivanova, Miron Kuznetsov, Ilya Sochenkov, Elizaveta Panchenko, Artem Shelmanov, Dmitry V. Dylov
arXiv:2606. 00123v1 Announce Type: cross Abstract: Multimodal Large Language Models (MLLMs) have shown strong performance on public medical benchmarks, yet existing evaluations often remain weak proxies for clinical use, relying on isolated inputs and simplified recognition-style tasks.
By Zixian Su, Hongkai Zhang, Fan Gao, Encheng Su, Taiping Qu, Jingwei Guo, Nan Zhang, Hui Wang, Zhen Zhou, Kairui Bo, Yan Chen, Yue Ren, Shuai Li, Lei Xu, Henggui Zhang
Therapy-induced cardiotoxicity is the leading non-oncological cause of treatment interruption in breast cancer patients, yet early, automated risk stratification from routine cardiac imaging remains an unsolved problem. We present EchoRisk, the first curated, multicentre, longitudinal echocardiography dataset with explicit cardiotoxicity labels, released as the primary technical reference for the EchoRisk-MICCAI 2026 challenge.
arXiv:2607. 11287v1 Announce Type: cross Abstract: Comprehensive quantification of cardiac structures from computed tomography (CT) remains limited not by data availability but by the scalability of measurements, which makes routine use impractical.
By Pooya Mohammadi Kazaj, Leo Fridolin Weber, Wen Xie, Seyed Amir Ahmad Safavi-Naini, Anselm Stark, Giovanni Baj, Ali Mokhtari, Toshiya Yoshida, Christoph Ryffel, Taishi Okuno, Yoshihiro Akashi, Ronny R. Buechel, Thomas Pilgrim, Waldo Valenzuela, George C. M. Siontis, Xiaowei Xu, Moritz Hundertmark, Stephan Windecker, Christoph Grani, Isaac Shiri