The paper introduces an inference-time sampler for pretrained diffusion models that extracts an intrinsic atlas of the population the model synthesizes, converging from any random seed to the population’s central anatomy. This method requires no retraining, works across multiple domains such as brain MRI, chest X-ray, faces, and 3D shapes, and can generate atlases for subpopulations like different ages. Evaluations show the intrinsic atlas performs as well or better than classical and learned templates for registration tasks and is the most central template for held‑out brain MRI cohorts.
arXiv:2608. 08319v1 Announce Type: cross Abstract: Brain magnetic resonance imaging (MRI) is central to neuroscience and clinical assessment, but models are commonly developed for individual diseases, populations or imaging protocols.
arXiv:2607. 02998v2 Announce Type: replace-cross Abstract: Controllable generative models of 3D medical images can synthesize volumes with specified clinical attributes, but this demands samples that are simultaneously high-fidelity, natively 3D, and faithful to the requested conditioning.
arXiv:2607. 02998v1 Announce Type: cross Abstract: Controllable generative models of 3D medical images can synthesize volumes with specified clinical attributes, but this demands samples that are simultaneously high-fidelity, natively 3D, and faithful to the requested conditioning.
arXiv:2609.17169v1 Announce Type: cross Abstract: Forecasting anatomical changes such as tumor growth and neurodegeneration is a challenging generative vision task. Morphological evolution is subtle...
We introduce SMART, a framework for learning a flexible, interpretable, and scalable spatio-temporal brain atlas from longitudinal high-resolution 3D medical images. Existing approaches to spatio-temporal atlas construction rely on black-box generative models that lack flexibility, limit interpretability, and struggle to scale to high-dimensional data.
arXiv:2606. 18354v1 Announce Type: cross Abstract: Recent advances in generative machine learning models have significantly improved medical imaging, offering promising solutions for data augmentation, privacy preservation, and improved model generalization.
The paper introduces Latent Drift, a generative forecasting framework that predicts slow-evolving neurodegenerative disease progression by learning changes in a compressed semantic representation rather than full-resolution anatomy. It addresses two failure modes—identity collapse and continuous interpolation trap—by removing pixel-level identity from the prediction target and applying Finite Scalar Quantization to suppress high-frequency nuisance fluctuations. Experiments on longitudinal 3D brain MRI demonstrate that Latent Drift outperforms diffusion and autoregressive transformer baselines in both generative fidelity and clinically relevant metrics.
DALE-CT introduces depth‑aware 2D slice encoders that learn an anatomical world model of chest CT scans without 3D or positional supervision. By sampling self‑supervised views across a physical $z$‑axis slab, the encoder captures how anatomy changes between neighboring slices, enabling it to recover slice ordering and distinguish slices by anatomy alone. The model, trained on a large 287k‑scan corpus, achieves state‑of‑the‑art performance on CT‑RATE and is released with full code and evaluation tools.
The paper introduces a high‑resolution Rectified Flow Matching model trained on 256×256 chest CT images to serve as a generative prior for CT reconstruction. A two‑stage training strategy—initial strong anatomically informed augmentation followed by fine‑tuning—helps mitigate overfitting and improve structural fidelity. When evaluated on various CT inverse problems, Flow Matching‑based reconstruction methods outperform diffusion‑based algorithms in PSNR, SSIM, and perceptual quality while requiring fewer sampling steps.
arXiv:2603. 04113v2 Announce Type: replace-cross Abstract: Demographic attributes can be predicted from medical images, raising concerns about bias in clinical AI systems.
arXiv:2608. 09460v1 Announce Type: new Abstract: Cardiac digital twin research is moving from subject-specific anatomical replicas toward virtual cohorts that represent clinically relevant population subgroups.
arXiv:2609.06807v1 Announce Type: cross Abstract: In this work, we comprehensively evaluate three popular feature-extraction paradigms in AI-based neuroimaging modeling: (1) computation of anatomical...