The paper introduces Order‑Aware Slab Multiple Instance Learning (OAS‑MIL), a weakly supervised method that predicts perineural invasion (PNI) risk in intrahepatic cholangiocarcinoma using preoperative T2‑weighted MRI. Tumor‑centered MRI crops are split into ordered 2.5D slabs, and a shared encoder extracts features that are aggregated through both permutation‑invariant set‑attention and bidirectional sequence‑attention branches. In five‑fold patient‑level cross‑validation, OAS‑MIL achieved a mean AUROC of 0.770, outperforming volumetric and other MIL baselines, indicating that preserving axial order improves non‑invasive PNI prediction.
By Hyunsu Go, Youngung Han, Kyeonghun Kim, Jinyong Jun, Junbeom Lee, Dohyun Kweon, Yului Jeong, Suah Park, Sungha Park, Anna Jung, Woo Kyoung Jeong, Ken Ying-Kai Liao, Hyuk-Jae Lee, Nam-Joon Kim
arXiv:2607. 10992v1 Announce Type: cross Abstract: Perineural invasion (PNI) is a clinically relevant indicator of tumor aggressiveness and can influence surgical decision-making, motivating interest in reliable preoperative assessment.
By Youngung Han, Hyunsu Go, Kyeonghun Kim, Induk Um, Junga Kim, Jaewon Jung, Woo Kyoung Jeong, Won Jae Lee, Pa Hong, Ken Ying-Kai Liao, Hyuk-Jae Lee, Nam-Joon Kim
arXiv:2607. 11533v1 Announce Type: cross Abstract: Perineural invasion (PNI) is a critical prognostic factor in cholangiocarcinoma.
By Youngung Han, Dohyun Kweon, Kyeonghun Kim, Hyunsu Go, Jina Jeong, Suah Park, Induk Um, Junga Kim, Anna Jung, Yului Jeong, Sungha Park, Jinyong Jun, Pa Hong, Woo Kyoung Jeong, Won Jae Lee, Ken Ying-Kai Liao, Hyuk-Jae Lee, Nam-Joon Kim
RACR-MIL is a weakly‑supervised method for grading squamous cell carcinoma (SCC) from whole‑slide images, using an attention‑based multiple‑instance learning framework. It introduces a hybrid WSI graph to capture local tissue context and non‑local phenotypic dependencies, and applies rank‑ordering constraints on attention to prioritize higher‑grade tumor regions, mirroring pathologists’ diagnostic reasoning. The approach achieves state‑of‑the‑art performance, improving SCC grading accuracy by 3–9% over existing methods and up to 10% in tumor localization, and a pilot study showed pathologists reported increased grading efficiency in 60% of cases.
By Anirudh Choudhary, Mosbah Aouad, Krishnakant Saboo, Angelina Hwang, Jacob Kechter, Blake Bordeaux, Puneet Bhullar, David DiCaudo, Steven Nelson, Nneka Comfere, Emma Johnson, Olayemi Sokumbi, Jason Sluzevich, Leah Swanson, Dennis Murphree, Aaron Mangold, Ravishankar Iyer
arXiv:2607. 10988v1 Announce Type: cross Abstract: Perineural invasion (PNI) is a critical prognostic factor in cholangiocarcinoma.
By Youngung Han, Induk Um, Kyeonghun Kim, Junga Kim, Hyunsu Go, Jaewon Jung, Woo Kyoung Jeong, Won Jae Lee, Pa Hong, Ken Ying-Kai Liao, Hyuk-Jae Lee, Nam-Joon Kim
arXiv:2607. 03253v1 Announce Type: cross Abstract: As hematoxylin & eosin (H&E) staining constitutes the primary entry point in routine diagnostic workflows, computer-aided diagnosis from whole-slide H&E images is of particular clinical relevance.
By Ivica Kopriva, Dario Sitnik, Arijana Pacic, Karolina Krstanac, Irena Veliki Dalic, Marijana Popovic Hadzija
arXiv:2606. 30951v1 Announce Type: cross Abstract: Micro-ultrasound ($\mu$US) is a new, emerging, and promising imaging modality for prostate cancer (PCa) detection, but accurate identification of suspicious tissue remains highly dependent on clinical experience, leading to substantial inter-observer variability.
By Mohammad Mahdi Abootorabi, Sina Namazi, Armin Saadat, Lyuyang Wang, Obed Dzikunu, Paul F. R. Wilson, Zhuoxin Guo, Brian Wodlinger, Parvin Mousavi, Purang Abolmaesumi
The paper presents an automated segmentation pipeline for whole‑slide histopathology images of colorectal cancer, labeling tumor grades 1‑3 and normal mucosa. It employs dense prediction transformers with multiple encoder backbones, overlapping patches, test‑time augmentation, and an adaptive augmentation policy guided by large language models. The approach, combined with soft‑voting ensembles and post‑processing refinements, raises the F1 score from 62.92 to 69.84 on a colorectal cancer grade dataset.
By \"Umit Mert \c{C}a\u{g}lar, Alptekin Temizel
Colorectal cancer (CRC) is the second most deadly and third most common cancer, and the leading cause of death among gastrointestinal cancers. Early diagnosis is crucial for the treatment of this canc...
arXiv:2607.10851v2 Announce Type: replace
Abstract: Medical image classification models are ideally expected to identify diagnostically relevant regions while making predictions, yet standard classif...
By Tonmoy Hossain, Atiqur Rahman, Farhana Hossain Swarnali, Miaomiao Zhang
arXiv:2606.28676v2 Announce Type: replace-cross
Abstract: Predicting distant metastasis from the digital H & E slides of the primary tumor is a critical yet challenging task in computational patholog...
By Sandesh Pokhrel, Hamid Manoochehri, Beatrice S Knudsen, Tolga Tasdizen
arXiv:2510. 17529v3 Announce Type: replace-cross Abstract: Active Surveillance (AS) is a treatment option for managing low and intermediate-risk prostate cancer (PCa), aiming to avoid overtreatment while monitoring disease progression through serial MRI and clinical follow-up.
By Yovin Yahathugoda, Davide Prezzi, Patricia A. Gutierrez, Piyalitt Ittichaiwong, Vicky Goh, Sebastien Ourselin, Michela Antonelli