arXiv:2606. 12346v1 Announce Type: cross Abstract: Hematoxylin and eosin (H&E) staining is the cornerstone of histopathology, yet scalable, quantitative analysis of H&E whole-slide images (WSIs) remains a central challenge in computational pathology.
By Kai Standvoss, Miriam H\"agele, Rosemarie Krupar, Julika Ribbat-Idel, Jennifer Altsch\"uler, Gerrit Erdmann, Hans Pinckaers, Evelyn Ramberger, Madleen Drinkwitz, \'Ad\'am N\'arai, Alexander M\"ollers, Katja Lingelbach, Sebastian Kons, Lukas H\"onig, Recepcan Adig\"uzel, Joana Bai\~ao, Alberto Megina Gonzalo, Marius Teodorescu, Marie-Lisa Eich, Paolo Chetta, Shakil Merchant, Verena Aumiller, Simon Schallenberg, Andrew Norgan, Klaus-Robert M\"uller, Lukas Ruff, Maximilian Alber, Frederick Klauschen
The paper presents a systematic evaluation of six unsupervised image‑to‑image generative models for virtual Sirius Red staining of mouse liver tissue from routine H&E slides. It benchmarks these models across 54 scaling configurations on a newly released paired H&E‑to‑SR dataset, assessing perceptual, distributional, and task‑specific performance, and further trains the best models into deep ensembles to quantify epistemic uncertainty. The study finds that GAN‑based and diffusion‑based methods differ markedly across these metrics, indicating that reliable virtual staining requires reporting and selecting on all three axes simultaneously.
By Qasim Siddiqui, Adrian Friebel, Maiju Myllys, Zaynab Hobloss, Daniela Gonzalez, Ahmed Ghallab, Stefan Hoehme
arXiv:2602. 02124v2 Announce Type: replace-cross Abstract: Drug-induced toxicity is a leading cause of preclinical and early-clinical failure, making early detection critical.
By Olga Graf, Dhrupal Patel, Peter Gro{\ss}, Charlotte Lempp, Matthias Hein, Fabian Heinemann
arXiv:2607.12750v3 Announce Type: replace
Abstract: Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer-related deaths globally, with approximatel...
By Elham Amjadi, Amin Bahreini, Sayed Mohammad Hasan Emami, Sayyed Mohammadreza Hakimian, Alireza Fahim, Hojjatollah Rahimi, Hamidreza Bolhasani
arXiv:2608. 15915v1 Announce Type: cross Abstract: Lung cancer remains the leading cause of cancer-related mortality worldwide, while histopathological diagnosis is often affected by inter-observer variability and the substantial workload associated with manual slide examination.
By Hadi Hasan, Safaa Salman, Lama Sleem, Ralph Mouawad, Ali Chehab
Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer-related deaths globally, with approximately 1,926,425 new cases and 904,019 deaths reported in 2022. Accurate histologic grading plays a critical role in prognosis and treatment planning for colorectal adenocarcinoma.