arXiv:2502.02707v5 Announce Type: replace Abstract: Multiple Instance Learning (MIL) for whole slide image (WSI) analysis in computational pathology often neglects instance-level learning as supervis...
arXiv:2606. 00092v1 Announce Type: cross Abstract: Weakly-supervised classification of whole-slide images with attention-based multiple instance learning (ABMIL) on top of foundation features now reaches near-saturation on Camelyon16 slide-level performance, but the corresponding attention maps are an imperfect localization signal: in clinical interpretation, a model that classifies correctly without firing on the actual lesion is hard to trust.
arXiv:2606. 07590v1 Announce Type: cross Abstract: Pathology foundation models are pretrained on large streams of WSI-derived patches, while supervision during data construction is often slide-level, sparse, or heterogeneous.
arXiv:2607. 10783v1 Announce Type: cross Abstract: Whole-slide images (WSIs) provide rich tissue-level and cellular-level information, but storing and transmitting high-magnification pathology data is resource-intensive.
arXiv:2608. 14719v1 Announce Type: cross Abstract: Multiple instance learning (MIL) is widely used for weakly supervised whole slide image (WSI) analysis.
arXiv:2607. 14703v1 Announce Type: cross Abstract: Multiple instance learning (MIL) has become the main paradigm for whole-slide image (WSI) analysis in computational pathology.
arXiv:2408.07988v3 Announce Type: replace Abstract: Despite significant research efforts and advancements, cancer remains a leading cause of mortality. Early cancer prediction has become a crucial fo...
arXiv:2608.30420v1 Announce Type: cross Abstract: Automating the analysis of whole-slide images has high clinical value, since characterizing cancers requires examining them in detail. Such analysis...
RACR-MIL is a weakly‑supervised method for grading squamous cell carcinoma (SCC) from whole‑slide images, using an attention‑based multiple‑instance learning framework. It introduces a hybrid WSI graph to capture local tissue context and non‑local phenotypic dependencies, and applies rank‑ordering constraints on attention to prioritize higher‑grade tumor regions, mirroring pathologists’ diagnostic reasoning. The approach achieves state‑of‑the‑art performance, improving SCC grading accuracy by 3–9% over existing methods and up to 10% in tumor localization, and a pilot study showed pathologists reported increased grading efficiency in 60% of cases.
arXiv:2603.12468v2 Announce Type: replace Abstract: Under strong cross-domain shifts, weakly supervised object localization (WSOL) models often lose their capacity to discriminate and develop a stron...
WILSON is a vision–language foundation model that represents whole‑slide images and multi‑slide patient cases as single multi‑magnification composite images. Trained on about 189,000 Mayo Clinic slides covering 42 organs and 829 diagnostic entities, it outperforms dedicated case‑level models on internal cohorts and matches slide‑level models while using far less compute. Fine‑tuning on triple‑negative breast cancer data improves histologic subtyping and lymphocyte grading, and the model retrieves diagnostic text with high recall and generates captions closer to report references than prior methods.
The study investigates whether pathology foundation models (PFMs) carry center-related biases into whole-slide image (WSI) classification. By training models with increasing class-center correlations and evaluating six PFMs across four datasets and two MIL aggregators, the authors introduce the Area Under the Cramér's V Curve (AUCC) to measure both accuracy and degradation due to spurious correlations. Results reveal that center information propagates to WSI predictions, with robustness varying by PFM and MIL strategy, and that ComBat harmonization does not consistently improve robustness.