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Stress-Testing EEG Foundation Models for Clinical Decoding: Dataset Identity and Targeted Negative Controls

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Pretrained EEG foundation models are increasingly proposed for clinical decoding, but their transfer across populations and robustness to negative controls remain unclear. We benchmark six models (LaBraM, EEGMamba, CBraMod, REVE, BENDR, and BIOT) on five clinical tasks across four datasets using frozen linear probes with leave-one-subject-out, subject-grouped, or explicitly identified recording-level splits.

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arXiv Machine Learning
Aug 31

Leveraging a Foundation Model for the EEG-Based Diagnosis of Alzheimer's Disease

The paper presents a diagnostic framework for Alzheimer’s disease that uses the Large Brain Model (LaBraM), a foundation model pretrained on over 2,500 hours of EEG data, to generate high‑dimensional latent embeddings. These embeddings are fed into a non‑linear Random Forest classifier, achieving an ROC‑AUC of 89.36% ± 3.49%, PR AUC of 81.45% ± 4.43%, and Balanced Accuracy of 82.44% ± 4.34% in a subject‑independent 5‑fold cross‑validation setting, using only 8‑second EEG segments. Post‑hoc occlusion and neurophysiological alignment analyses confirm that the model captures clinically validated biomarkers such as occipital‑frontal Alpha and Theta rhythm degradation and correlates with cognitive performance and clinical severity.

By Maggie Lin, Chung-Lin Hou, Tzyy-Ping Jung