arXiv:2606. 09893v1 Announce Type: cross Abstract: Diffusion MRI (dMRI) tractography is the only noninvasive approach for mapping white-matter pathways in the living human brain.
arXiv:2607. 16325v1 Announce Type: cross Abstract: Foundation models provide powerful representations for brain MRI analysis, but their predictions remain difficult to interpret in anatomically meaningful terms.
arXiv:2604. 27277v3 Announce Type: replace-cross Abstract: Brain MRI underpins a wide range of neuroscientific and clinical applications, yet most learning-based methods remain task-specific and require substantial labeled data.
Machine learning (ML) has emerged as a promising approach for improving diffusion MRI (dMRI) tractography, a task that remains limited by the intrinsic tension between local diffusion information and...
arXiv:2606. 19651v1 Announce Type: new Abstract: Three-dimensional (3D) brain MRI is central to clinical neurology and neuro-oncology, where generative models could augment under-represented cohorts, simulate disease trajectories, and support privacy-preserving data sharing.
The paper presents a systematic comparison of recurrent neural networks and Transformer models for iterative diffusion MRI tractography, focusing on training strategies, input representations, and hyperparameter tuning. It introduces a generation‑validation phase that provides streamline‑level supervision, enabling the models to achieve the best performance reported on the ISMRM2015 challenge dataset. The study also evaluates the effects of missing bundles, noisy training data, and invalid fibers, and demonstrates applicability to in‑vivo data from the Tractoinferno database.
arXiv:2604. 22700v2 Announce Type: replace Abstract: Modeling and predicting neurodegenerative disease progression from medical images remains a major challenge in medical AI, with significant implications for early diagnosis, disease monitoring, and treatment planning.
Fiber tractography's ability to reconstruct the brain's structural pathways, has made it a crucial component of modern neuroimaging, enabling detailed, non-invasive mapping of structural connectivity and supporting a wide range of neurological research and clinical applications. However, despite its importance, tractography remains a challenging task due to the inherent complexity of white matter structure and its susceptibility to false positives, which can lead to the misrepresentation of critical pathways.
The paper presents a multimodal 3D convolutional neural network that classifies Alzheimer’s disease using raw OASIS 1 MRI volumes. It fuses structural T1 images with gray matter, white matter, and cerebrospinal fluid probability maps to capture complementary neuroanatomical information. Evaluated with 5‑fold subject‑level cross‑validation, the model achieves a mean accuracy of 72.34 % and an ROC AUC of 0.7781, with GradCAM visualizations highlighting anatomically relevant regions such as the medial temporal lobe and ventricles.
The paper introduces a Geometric-to-Semantic Spherical Transfer Learning framework for labeling cortical sulci on brain surfaces. It first pre‑trains a spherical encoder on ~30,000 unlabeled UK Biobank subjects using only curvature and depth, then injects sulcal fundi lines as a soft‑initialized Topological Prior Injector to bridge the geometric‑semantic gap. Experiments show the method surpasses fully supervised baselines, achieving a mean Dice score of 0.77 and delivering the largest gains on variable and tertiary sulci.
arXiv:2606. 04772v1 Announce Type: cross Abstract: Understanding the relationship between deep visual representations and the human visual system is a fundamental challenge in computational neuroscience.
arXiv:2607. 17782v1 Announce Type: cross Abstract: Foundation models pretrained using self-supervised learning have transformed computer vision by learning transferable representations from large-scale unlabeled data.
The paper investigates combining a domain‑specific self‑supervised task—voxel‑level brain age prediction—with a general task—image inpainting—to pretrain models for brain MRI segmentation. A multitask pretraining framework jointly optimizes both objectives, yielding representations that outperform single‑task pretraining and training from scratch on three segmentation benchmarks (multiple sclerosis lesions, ischemic stroke lesions, and cortical structures). The study demonstrates that integrating domain‑specific and general self‑supervised tasks benefits the development of generalizable neuroimaging foundation models.