The paper presents a systematic comparison of recurrent neural networks and Transformer models for iterative diffusion MRI tractography, focusing on training strategies, input representations, and hyperparameter tuning. It introduces a generation‑validation phase that provides streamline‑level supervision, enabling the models to achieve the best performance reported on the ISMRM2015 challenge dataset. The study also evaluates the effects of missing bundles, noisy training data, and invalid fibers, and demonstrates applicability to in‑vivo data from the Tractoinferno database.
By Emmanuelle Renauld, Philippe Poulin, Hugo Larochelle, Antoine Th\'eberge, Maxime Descoteaux
Fiber tractography's ability to reconstruct the brain's structural pathways, has made it a crucial component of modern neuroimaging, enabling detailed, non-invasive mapping of structural connectivity and supporting a wide range of neurological research and clinical applications. However, despite its importance, tractography remains a challenging task due to the inherent complexity of white matter structure and its susceptibility to false positives, which can lead to the misrepresentation of critical pathways.
arXiv:2606. 09893v1 Announce Type: cross Abstract: Diffusion MRI (dMRI) tractography is the only noninvasive approach for mapping white-matter pathways in the living human brain.
By Guikun Chen, Yuqian Chen, Yijie Li, Yogesh Rathi, Nikos Makris, Fan Zhang, Wenguan Wang, Lauren J. O'Donnell
Brain tissue microstructure estimation with machine learning provides higher computational efficiency than conventional fitting. However, machine learning still presents important limitations that hamper its clinical utility.
FlowMoDL is an unrolled neural network designed for highly accelerated 4D flow MRI reconstruction, optimizing both anatomical magnitude and phase-derived velocity accuracy. It alternates a learned (3+1)D spatiotemporal denoiser with conjugate‑gradient data‑consistency updates, using a dual‑pathway conditioning scheme to handle acceleration factors from 10× to 50×. Trained with a deep‑supervision composite loss that penalizes velocity magnitude and angular errors, FlowMoDL outperforms classical and deep‑learning baselines on the multi‑center CMRx4DFlow dataset, achieving superior gradient‑step efficiency and robust convergence across all acceleration factors.
By Tristan Gottwald, Michelle Bruch, Mubashir-Ul Hassan, Fatma Alickovic, Milan Kloiber, Daniel Tenbrinck, Torsten Panholzer, Melanie Schaller, Jana Hutter
arXiv:2606. 19651v1 Announce Type: new Abstract: Three-dimensional (3D) brain MRI is central to clinical neurology and neuro-oncology, where generative models could augment under-represented cohorts, simulate disease trajectories, and support privacy-preserving data sharing.
By Max Van Puyvelde, Ibrahim Gulluk, Wim Van Criekinge, Olivier Gevaert
arXiv:2606. 26898v1 Announce Type: cross Abstract: Diffusion MRI (dMRI) tractography enables non-invasive reconstruction of white-matter pathways, but its accuracy is fundamentally limited by indirect, low-resolution measurements of axonal organization.
By Kyriaki-Margarita Bintsi, Sparsh Makharia, Ya\"el Balbastre, Joselyn Romero Avila, Julia F. Lehman, Suzanne N. Haber, Anastasia Yendiki
The paper introduces CM-RED, a fast MRI reconstruction method that combines a pretrained consistency model with the regularization by denoising framework. By integrating controlled noise injection into accelerated proximal gradient updates, CM-RED achieves high‑quality reconstructions on fastMRI knee and brain datasets with only four network function evaluations. It consistently outperforms existing diffusion‑ and consistency‑based approaches in quantitative metrics, visual fidelity, and robustness to hyperparameter changes.
By Merve G\"ulle, Junno Yun, Ya\c{s}ar Utku Al\c{c}alar, Mehmet Ak\c{c}akaya
arXiv:2608. 03990v1 Announce Type: new Abstract: Synthetic histopathology image generation has emerged as an approach that may address data scarcity in computational pathology, yet current evaluation methodologies may not fully assess synthetic data quality for medical applications.
By Seyed Kahaki, Shijie Li, Weijie Chen, Nicholas Petrick
We introduce TCAM-Diff, a novel 3D medical image generation model that reduces the memory requirements to encode and generate high-resolution 3D data. This model utilizes a decoder-only autoencoder method to learn triplane representation from dense volume and leverages generalization operations to prevent overfitting.
arXiv:2610.00279v1 Announce Type: new
Abstract: The segmentation of anatomical structures in medical images and particularly in MRI scans, is essential for clinical diagnosis and monitoring disease p...
By Eirini Cholopoulou, Dimitrios E. Diamantis, Dimitris K. Iakovidis
The paper introduces a transfer‑learning framework that pre‑trains an implicit neural representation (INR) on a high‑resolution diffusion MRI template and then adapts it to individual subjects through registration and fine‑tuning. This approach enables native single‑subject super‑resolution, achieving a 4× through‑plane up‑sampling from 5 mm to 1.25 mm on Human Connectome Project data. Compared to a recent baseline, the method reduces NRMSE by 36–49 % and increases FSIM by 24–43 %, while training 6× faster and outperforming other INR‑based techniques on both image quality and domain‑specific metrics.
By Abdulkader Ghandoura, Marsil Zakour, William Consagra, Yogesh Rathi