arXiv Machine Learning

GraM-Diff: A Unified Graph-Mamba Diffusion Framework for EEG-Based Alzheimer's Disease Data Generation and Diagnosis

arXiv AI
Jun 8

LuMamba: Latent Unified Mamba for Electrode Topology-Invariant and Efficient EEG Modeling

arXiv:2603. 19100v2 Announce Type: replace Abstract: Electroencephalography (EEG) enables non-invasive monitoring of brain activity across clinical and neurotechnology applications, yet building foundation models for EEG remains challenging due to differing electrode topologies and computational scalability, as Transformer architectures incur quadratic sequence complexity.

By Dana\'e Broustail, Anna Tegon, Thorir Mar Ingolfsson, Yawei Li, Luca Benini
arXiv Machine Learning
Sep 14

DCRA: Diffusion-Conditioned Representation Alignment for Robust Time-Series Learning

The paper introduces Diffusion-Conditioned Representation Alignment (DCRA), a training framework that uses the forward diffusion process as a structured corruption scheduler for time‑series representation learning. DCRA aligns representations across noise levels with a feature‑level consistency objective, preserving class‑discriminative structure and enabling smooth, semantically coherent trajectories in latent space. Experiments on the CHB‑MIT EEG dataset demonstrate that DCRA improves seizure detection performance under various noise conditions, achieving higher sensitivity at low false‑positive rates and producing more balanced, structured representations than baseline methods.

By Wenrui Xu, Anas Enanaa, Keshab K. Parhi
arXiv Machine Learning
Jun 25

SDE-Driven Spatio-Temporal Hypergraph Neural Networks for Irregular Longitudinal fMRI Connectome Modeling in Alzheimer's Disease

arXiv:2603. 20452v2 Announce Type: replace Abstract: Longitudinal neuroimaging is essential for modeling disease progression in Alzheimer's disease (AD), yet irregular sampling and missing visits pose substantial challenges for learning reliable temporal representations.

By Ruiying Chen, Yutong Wang, Houliang Zhou, Wei Liang, Yong Chen, Lifang He
arXiv Computer Vision
Aug 21

4DLoG: Generative Modeling of Neurodegenerative Brain Anatomy with 4D Longitudinal Diffusion Model

arXiv:2604. 22700v2 Announce Type: replace Abstract: Modeling and predicting neurodegenerative disease progression from medical images remains a major challenge in medical AI, with significant implications for early diagnosis, disease monitoring, and treatment planning.

By Nivetha Jayakumar, Swakshar Deb, Bahram Jafrasteh, Qingyu Zhao, Miaomiao Zhang
arXiv AI
Sep 1

EEGDM: Learning EEG Representation with Latent Diffusion Model

EEGDM introduces a self‑supervised framework that uses latent diffusion models to generate EEG signals, moving beyond traditional masked reconstruction. The method employs an EEG encoder to produce a compact representation that conditions the diffusion denoising process, allowing joint optimization of encoder and generator. Experiments demonstrate that EEGDM can reconstruct high‑quality EEG, learn robust representations, and perform competitively on various downstream tasks.

By Shaocong Wang, Tong Liu, Yihan Li, Ming Li, Kairui Wen, Pei Yang, Wenqi Ji, Minjing Yu, Yong-Jin Liu
arXiv Machine Learning
Aug 31

Leveraging a Foundation Model for the EEG-Based Diagnosis of Alzheimer's Disease

The paper presents a diagnostic framework for Alzheimer’s disease that uses the Large Brain Model (LaBraM), a foundation model pretrained on over 2,500 hours of EEG data, to generate high‑dimensional latent embeddings. These embeddings are fed into a non‑linear Random Forest classifier, achieving an ROC‑AUC of 89.36% ± 3.49%, PR AUC of 81.45% ± 4.43%, and Balanced Accuracy of 82.44% ± 4.34% in a subject‑independent 5‑fold cross‑validation setting, using only 8‑second EEG segments. Post‑hoc occlusion and neurophysiological alignment analyses confirm that the model captures clinically validated biomarkers such as occipital‑frontal Alpha and Theta rhythm degradation and correlates with cognitive performance and clinical severity.

By Maggie Lin, Chung-Lin Hou, Tzyy-Ping Jung