arXiv AI By Yihe Wang, Nan Huang, Nadia Mammone, Marco Cecchi, Xiang Zhang

LEAD: An EEG Foundation Model for Alzheimer's Disease Detection

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LEAD is a gated temporal‑spatial Transformer foundation model designed for EEG‑based Alzheimer's disease detection. It was trained on the world’s largest EEG‑AD corpus of 2,238 subjects and uses a subject‑regularized strategy and medical contrastive learning across 13 datasets. LEAD outperforms existing methods on five downstream AD datasets, achieving the best average ranking across 20 evaluations.

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