arXiv:2510. 11917v2 Announce Type: replace Abstract: Dementia disorders such as Alzheimer's disease (AD) and frontotemporal dementia (FTD) exhibit overlapping electrophysiological signatures in EEG that challenge accurate diagnosis.
arXiv:2608. 14847v1 Announce Type: new Abstract: Electroencephalogram (EEG) is a non-invasive and relatively low-cost procedure that measures brain electricity for the detection of cognitive diseases.
The paper presents a diagnostic framework for Alzheimer’s disease that uses the Large Brain Model (LaBraM), a foundation model pretrained on over 2,500 hours of EEG data, to generate high‑dimensional latent embeddings. These embeddings are fed into a non‑linear Random Forest classifier, achieving an ROC‑AUC of 89.36% ± 3.49%, PR AUC of 81.45% ± 4.43%, and Balanced Accuracy of 82.44% ± 4.34% in a subject‑independent 5‑fold cross‑validation setting, using only 8‑second EEG segments. Post‑hoc occlusion and neurophysiological alignment analyses confirm that the model captures clinically validated biomarkers such as occipital‑frontal Alpha and Theta rhythm degradation and correlates with cognitive performance and clinical severity.
The paper introduces Explainable Graph-theoretical Machine Learning (XGML) to build individual metabolic brain graphs from FDG-PET data and identify subgraphs predictive of multivariate Alzheimer’s disease outcomes. Using ADNI data, the best model—kernel density estimation with Hellinger distance and random forest—achieved a Pearson correlation of 0.595 across eight cognitive scores, with the highest performance on ADAS13, ADAS11, and ADASQ4. Key edges were found to be jointly but differentially predictive, indicating potential network biomarkers for cognitive decline, though external validation on OASIS3 showed weaker performance likely due to cohort differences.
arXiv:2607. 28681v1 Announce Type: cross Abstract: Functional magnetic resonance imaging (fMRI) is a widely used technique for studying the brain.
arXiv:2608.29755v1 Announce Type: new Abstract: Electroencephalography (EEG) is a promising, non-invasive, and cost-effective modality for Alzheimer's disease (AD) detection, but deep learning method...
arXiv:2606. 03322v1 Announce Type: cross Abstract: The graphical representation of the brain offers critical insights into diagnosing and prognosing neurodegenerative disease via relationships between regions of interest (ROIs).
arXiv:2607. 19429v1 Announce Type: new Abstract: Electroencephalographic (EEG) abnormalities arise from dynamic changes in neural synchrony across spatial and temporal scales, yet many computational approaches reduce these dynamics to static features.
arXiv:2512. 10966v3 Announce Type: replace-cross Abstract: Accurate and early diagnosis of Alzheimer's disease (AD) is critical for effective intervention and requires integrating complementary information from multimodal neuroimaging data.
arXiv:2606. 04699v1 Announce Type: cross Abstract: Early and accurate detection of Alzheimer's disease (AD) is important for timely intervention and disease management.
arXiv:2608.20380v1 Announce Type: cross Abstract: Resting-state functional magnetic resonance imaging (rs-fMRI) has enabled non-invasive mapping of functional brain interactions for computer-aided di...
arXiv:2607. 14314v1 Announce Type: new Abstract: Seizure diagnosis from EEG signals is a critical yet persistently challenging task, due to the complicated neural dynamics and the spurious connections in inter-channel modeling.
arXiv:2604. 00163v2 Announce Type: replace-cross Abstract: Epileptic seizures are neurological disorders characterized by abnormal and excessive electrical activity in the brain, resulting in recurrent seizure events.